Washington State University Spokane

Effect of a Mentored Virtual Research Fellowship on Research Competencies and Activities of Nurses

Background: Nurses should lead research activities to improve patient care, especially in Magnet ® -designated hospitals. One organization used a 6-month virtual mentored registered nurse research fellowship to overcome participation barriers. Method: Nurses across 24 hospitals i...

Lipid Mediators as Therapeutic Targets in Prostate Cancer

Lipid mediators are small molecules, derived from lipid metabolism, that initiate cellular responses. In this review, the major classes of lipid mediators are considered with respect to their effects on prostate cancer cells. These classes are: sphingolipids (sphingosine 1-phosph...

Cannabis use among Native Americans experiencing pain within two U.S. Northwest clinics: a qualitative study

Abstract Background Cannabis is increasingly used by adults with pain, yet little is known about its current use by Native American people. Objective To describe the perspectives from a sample of Native American adults experiencing pain regarding their use of cannabis and its imp...

Drugging the Undruggable in Oncology: Structural Computation, Machine Learning, and Generative AI for Historically Intractable Targets

For four decades the central oncogenic drivers of human cancer the RAS GTPases, the transcription-factor MYC, mutant p53, and the protein-tyrosine phosphatases, fusion oncoproteins and intrinsically disordered regulators that surround them were regarded as undruggable: lacking de...

Current translational perspectives for diagnosis and individualized therapy in rare genetic diseases

Rare diseases affect hundreds of millions of individuals worldwide, primarily resulting from genetic factors, with many presenting during childhood. Advances in genome sequencing increasingly enable identification of the responsible gene in more patients; however, only a limited...

Targeting tryptophan hydroxylase 1 restricts growth and suppresses plasticity in neuroendocrine prostate cancer

Advanced prostate cancer has increasingly developed a lethal neuroendocrine form, small cell/neuroendocrine prostate cancer (NEPC), as a consequence of the widespread use of highly potent androgen receptor signaling inhibitors in castration-resistant disease. The molecular mechan...

Design Principles of Optimizing Cementitious Glasses for the Disposal of Radioactive Waste

ABSTRACT We designed, synthesized, and characterized 26 cementitious calcium‐magnesium aluminosilicate (CMAS) glasses using the chemical and mineralogical properties of ordinary Portland cement (OPC), ground, granulated blast furnace slag (BFS), and class F fly ash as bounding co...

Light during the rest phase disrupts hippocampal clock function and impairs object recognition memory

Light exposure in the circadian rest phase is common during shift work and late-night activity, but its effects on memory remain unclear. Using male C57BL/6J mice, we show 6-day rest-phase light exposure (RPL), which combines mistimed light exposure with enforced wakefulness, imp...

Leveraging Google location history data to assess the impact of activities, locations, and time spent in green space on mental health during the COVID-19 pandemic

Abstract The COVID-19 pandemic led to stay-at-home orders, resulting in sudden changes in movement patterns and social restrictions that impacted mental health. This study examined changes in individual behaviors during the pandemic using detailed smartphone-based activity data a...

Determinants of Cognitive Change Over 1 Year in Older Adults With Type 1 Diabetes

OBJECTIVE Older adults with type 1 diabetes (T1D) have a greater risk for cognitive decline, highlighting the need to identify risk factors for meaningful cognitive change using brief screening tools suitable for annual wellness examinations. RESEARCH DESIGN AND METHODS This stud...

Dynamic Protein Structure Paradox: An Integrative Framework for Endpoint-Conditioned Evidentiary Sufficiency in Structure-to-Function Claims

Accurate coordinates for a represented protein state do not, by themselves, establish activity or any other condition-specific function. This article defines the Dynamic Protein Structure Paradox (DPSP) as the apparent conflict between structural accuracy and functional underdete...

The role of CYP3A-CYP2E1 interactions in activation of CYP3A enzymes by chronic alcohol exposure

To examine the effect of chronic alcohol exposure on the activity of CYP3A enzymes in human liver, we studied the metabolism of CYP3A-specific substrates 7-benzyloxyquinoline (7-BQ) and ivermectin in 23 preparations of human liver microsomes (HLM) obtained from donors with docume...