Institution
Washington State University Spokane
USeducation
Recent research
- Health & MedicineOpen access
The role of CYP3A-CYP2E1 interactions in activation of CYP3A enzymes by chronic alcohol exposure
To examine the effect of chronic alcohol exposure on the activity of CYP3A enzymes in human liver, we studied the metabolism of CYP3A-specific substrates 7-benzyloxyquinoline (7-BQ) and ivermectin in 23 preparations of human liver microsomes (HLM) obtained from donors with docume...