Wannan Medical College

Bilayer Polycaprolactone (Mitomycin C)/Poly(L-Lactic Acid)/Gelatine (Dimethyloxalylglycine) Nanofibres for Diabetic Wound Repair

Background: Diabetic skin wounds arise from chronic hyperglycaemia, peripheral neuropathy, microvascular dysfunction, and compromised immunity. Chronic ulcers are further complicated by infection and local ischaemia–hypoxia, which collectively impede tissue repair. Conventional i...

Differential effects of PM2.5 constituents on tuberculosis infection and disease progression in 40,379 student close contacts

Abstract Rationale Outdoor PM2.5 has been increasingly implicated in tuberculosis, yet evidence has largely focused on total PM2.5 mass and has usually considered Mycobacterium tuberculosis (M. tuberculosis) infection and active tuberculosis separately. Whether specific PM2.5 che...

HLA-DMA depletion suppresses malignant glioma phenotypes and murine H2-DMa knockdown enhances the response to anti-PD-1 therapy

Glioblastoma (GBM) exhibits poor responsiveness to immune checkpoint blockade, largely due to an immunosuppressive tumor immune microenvironment. Tumor-associated macrophage (TAM) polarization critically regulates antitumor immunity, yet the role of human leukocyte antigen class...

UDSQ: a secure and efficient user-defined dynamic skyline query in online medical diagnosis

With the rapid development of information technology, online medical diagnosis services have become increasingly prevalent. These services improve healthcare accessibility for patients in regions with limited medical resources. However, online medical diagnosis still faces signif...

A dual-channel deep learning framework integrating preoperative and intraoperative multi-phase data for predicting post-ablation recurrence in atrial fibrillation

Predicting atrial fibrillation (AF) recurrence after catheter ablation is essential for optimizing postoperative management. This study developed the Ablation-Clinical Fusion Transformer (ACFT), a dual-channel framework integrating structured intraoperative ablation sequences wit...

TRIM3 functions as a tumor suppressor and predicts prognosis in triple-negative breast cancer: a multi-omics study with clinical cohort validation

Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype with poor prognosis and limited treatment options. Tripartite motif-containing protein 3 (TRIM3), an E3 ubiquitin ligase, has been implicated as a tumor suppressor in several cancers; however, its biologi...

Effect Modification of Rescue Stenting in ICAS-Related Middle Cerebral Artery Occlusion: The Role of Thrombectomy Failure, Stenosis Severity, and ASPECTS

Rescue stenting (RS) is increasingly used for intracranial artery stenosis-related large vessel occlusion (ICAS-LVO), but optimal patient selection remains uncertain. We investigated the baseline and procedural factors associated with receiving RS and whether they modified the as...

Senescent pulmonary epithelial cells-derived S100A10 drives epithelial-fibroblast crosstalk through inhibiting vimentin ubiquitination in pulmonary fibrosis

Pulmonary fibrosis is a chronic, lethal, and ageing-associated interstitial lung disease of unknown aetiology, involves pulmonary epithelial cell senescence and fibroblast activation. However, the underlying mechanism remains elusive. This study aims to investigate the role and p...

Olink proteomics reveals immuno-inflammatory profile changes and potential regulatory mechanisms of non-suicidal self-injury behavior associated with depression in adolescent

Abstract Background N on- s uicidal s elf- i njury (NSSI) frequently co-occurs with adolescent depression. The underlying immunoinflammatory mechanisms and peripheral biomarkers remain poorly understood. This study aimed to identify plasma proteins associated with NSSI in depress...

Routine clinical test markers with MRI anatomical anchoring for dysphagia risk identification in wilson disease: model development and external validation using a two-center database

Wilson disease (WD)-related dysphagia may lead to aspiration, pulmonary infection and malnutrition, but it is often recognized late in routine care. This study evaluated the value of routine clinical test markers, magnetic resonance imaging (MRI) topography and their integration...

Effect of dexmedetomidine as an adjuvant to ropivacaine in stellate ganglion block on postoperative sleep quality in patients undergoing thyroid cancer surgery: a randomized double-blind controlled trial

Postoperative sleep disturbance is common after thyroid cancer surgery and may delay recovery. Stellate ganglion block (SGB) can regulate sympathetic activity, but single local anesthetic blockade has limited duration. This trial aimed to evaluate whether perineural addition of d...

Anatomical and Morphological Structure of the Lesser Occipital Nerve.

Objective To characterize the anatomical features of the lesser occipital nerve，thereby providing an applied anatomical basis for cervical neuralgia and local surgical procedures. Methods This study included both left and right sides of 40 adult formalin-fixed adult human specim...

Targeting PKM2 Enhances the Anti-Tumor Function of CD8+ T Cells Through Metabolic Reprogramming

The efficacy of adoptive cell transfer (ACT) therapy in solid tumors is often limited by the functional exhaustion and insufficient persistence of infused CD8+ T cells within the tumor microenvironment. Through the integrated analysis of single-cell transcriptomic data, this stud...

Serial echocardiographic changes in left ventricular size and calculated mass after transcatheter aortic valve replacement for predominant native aortic regurgitation without severe aortic stenosis: a retrospective cohort study

Left ventricular end-diastolic diameter (LVEDD) is widely available but is one-dimensional and load dependent. We evaluated serial LV size and calculated LV mass after TAVR for predominant native aortic regurgitation (AR) without severe aortic stenosis (AS), using all quantitativ...

XGBoost Classification of Epileptic EEG Using Nonlinear Dynamical Features and SHAP

To evaluate whether nonlinear descriptors of electroencephalogram (EEG) signals support interpretable XGBoost classification and to determine how analysis window duration affects performance. A secondary analysis of the public Bonn EEG dataset was performed. Nine nonlinear featur...

Synergistic attack of “old drugs for new uses”: repositioning strategies in cancer combination therapy

Cancer treatment faces severe challenges such as drug resistance, side effects, and high costs. The “repurposing old drugs” strategy, which involves repositioning approved drugs for non-oncology indications for cancer treatment, has opened up new avenues for developing efficient,...

A case report of rare primary extraosseous Ewing sarcoma of the bladder is presented, with confirmation by pathological, immunohistochemical, and molecular analyses

Extraosseous Ewing sarcoma (EES) of the bladder is an extremely rare, highly aggressive small round cell malignancy. Because its clinical manifestations and imaging features are nonspecific and its histological appearance closely mimics that of other small round cell tumors, misd...

Advances in Cyclic Peptides Targeting G Protein‐Coupled Receptors

Peptide‐responsive G protein‐coupled receptors (GPCRs) often recognize endogenous peptide ligands through extended receptor interfaces, providing opportunities for peptide‐based ligands to engage receptor contacts that conventional small molecules struggle to access effectively....

SNX4 promotes glioblastoma progression through the TGFβ1/Smad signaling pathway and represents a potential therapeutic target

Abstract Background Glioblastoma multiforme (GBM) is a highly malignant primary brain tumor that still lacks highly specific and clinically effective molecular targets for GBM treatment. Sorting Nexin 4 (SNX4) is an important regulatory molecule involved in intracellular membrane...

The effect of cochlear implantation in older adults: an umbrella review of systematic reviews and meta-analyses

INTRODUCTION: Age-related hearing loss is increasingly prevalent and impacts psychosocial wellbeing, cognitive health, and quality of life in older adults. While cochlear implants (CIs) are effective for severe-to-profound loss, their use in the elderly was historically cautious....