Wannan Medical College

Serial echocardiographic changes in left ventricular size and calculated mass after transcatheter aortic valve replacement for predominant native aortic regurgitation without severe aortic stenosis: a retrospective cohort study

Left ventricular end-diastolic diameter (LVEDD) is widely available but is one-dimensional and load dependent. We evaluated serial LV size and calculated LV mass after TAVR for predominant native aortic regurgitation (AR) without severe aortic stenosis (AS), using all quantitativ...

XGBoost Classification of Epileptic EEG Using Nonlinear Dynamical Features and SHAP

To evaluate whether nonlinear descriptors of electroencephalogram (EEG) signals support interpretable XGBoost classification and to determine how analysis window duration affects performance. A secondary analysis of the public Bonn EEG dataset was performed. Nine nonlinear featur...

Synergistic attack of “old drugs for new uses”: repositioning strategies in cancer combination therapy

Cancer treatment faces severe challenges such as drug resistance, side effects, and high costs. The “repurposing old drugs” strategy, which involves repositioning approved drugs for non-oncology indications for cancer treatment, has opened up new avenues for developing efficient,...

A case report of rare primary extraosseous Ewing sarcoma of the bladder is presented, with confirmation by pathological, immunohistochemical, and molecular analyses

Extraosseous Ewing sarcoma (EES) of the bladder is an extremely rare, highly aggressive small round cell malignancy. Because its clinical manifestations and imaging features are nonspecific and its histological appearance closely mimics that of other small round cell tumors, misd...

Advances in Cyclic Peptides Targeting G Protein‐Coupled Receptors

Peptide‐responsive G protein‐coupled receptors (GPCRs) often recognize endogenous peptide ligands through extended receptor interfaces, providing opportunities for peptide‐based ligands to engage receptor contacts that conventional small molecules struggle to access effectively....

SNX4 promotes glioblastoma progression through the TGFβ1/Smad signaling pathway and represents a potential therapeutic target

Abstract Background Glioblastoma multiforme (GBM) is a highly malignant primary brain tumor that still lacks highly specific and clinically effective molecular targets for GBM treatment. Sorting Nexin 4 (SNX4) is an important regulatory molecule involved in intracellular membrane...

The effect of cochlear implantation in older adults: an umbrella review of systematic reviews and meta-analyses

INTRODUCTION: Age-related hearing loss is increasingly prevalent and impacts psychosocial wellbeing, cognitive health, and quality of life in older adults. While cochlear implants (CIs) are effective for severe-to-profound loss, their use in the elderly was historically cautious....

Predictive Value of Imaging Indicators for Disease Progression in Acute Stanford Type B Aortic Intramural Hematoma Without Ulcer-like Lesions

PURPOSE: To investigate the clinical outcomes of acute Stanford type B intramural hematoma (TBIMH) without ulcer-like lesions following medical management and to identify predictors of disease progression. MATERIALS AND METHODS: A retrospective analysis was performed on patients...

Identification and validation of CCL28 and CCL5 as chemokine biomarkers and pro-inflammatory mediators in acute pancreatitis: an integrated bioinformatics and experimental study

Acute pancreatitis (AP) is a common inflammatory disease of the exocrine pancreas. Its course ranges from a mild, self-limited illness to severe disease with organ failure. Current clinical tools do not reliably identify patients at risk of progression early in the disease course...

Factors associated with early hematoma expansion in intracerebral hemorrhage and the value of non-contrast computed tomography imaging features combined with clinical data for early identification

PURPOSE: Early hematoma expansion (HE) after intracerebral hemorrhage (ICH) critically affects patient outcomes. Identifying HE risk using emergency non-contrast computed tomography (NCCT) features and clinical data is important for early risk stratification and evaluation. This...

Application of the modified Mini-CEX combined with the SBAR model in the experimental teaching of health assessment course: a quasi-experimental study

Abstract Objective This study aimed to explore the effects of the modified Mini-Clinical Evaluation Exercise (Mini-CEX) combined with the Situation-Background-Assessment-Recommendation (SBAR) model in the experimental teaching of Health Assessment course. Background The Mini-cex...