Wan Fang Hospital

Soluble N-terminal EphA2 fragment as a diagnostic biomarker and functional mediator of tumor progression in triple-negative breast cancer

Triple-negative breast cancer (TNBC) lacks reliable biomarkers for early detection and remains a highly aggressive disease. Ephrin type-A receptor 2 (EphA2), a receptor tyrosine kinase frequently overexpressed in advanced cancers, undergoes MMP14-mediated cleavage that releases s...

Altered saccade control reveals executive dysfunction in late-life depression

Late-life depression (LLD) is frequently accompanied by executive dysfunction, which is associated with poorer clinical outcomes but remains difficult to assess objectively in older adults. Saccadic eye movements provide a rapid and non-invasive approach for probing executive-con...

Structure-based identification and biological evaluation of a novel MAPKAPK2 inhibitor for pancreatic cancer

Pancreatic cancer remains a lethal malignancy with few effective treatment options. MAPKAPK2, a downstream effector of p38 signaling, represents a potential target for disrupting tumor survival pathways. Structure-guided computational screening has become an important strategy fo...

More-efficient water splitting utilizing heated-cooled active pure water with reduced hydrogen bonds

Within the realm of renewable energy technologies—particularly those centered on hydrogen evolution reactions (HERs) and oxygen evolution reactions (OERs)—noble metals have long been regarded as the archetypal catalytic materials. In recent years, however, research efforts have p...

SLC35D1 Is Associated with Colorectal Cancer Progression, EMT-Related Phenotypes, and Immune Infiltration

Colorectal cancer (CRC) is one of the most common malignancies worldwide, and the prognosis of patients with metastatic disease remains poor. Solute carrier proteins participate in diverse cellular processes, yet the biological and clinical relevance of the SLC35D family in CRC r...

Claudin 18 is not a biomarker for breast mucinous tumor

BACKGROUND: Breast mucinous cystadenocarcinoma (BMCA) is an exceptionally rare malignancy that may resemble mucinous neoplasms of the pancreas, ovary, lung and colorectum. Claudin 18 (CLDN18), particularly its gastric-associated isoform CLDN18.2, is an emerging therapeutic target...

Sodium-glucose cotransporter-2 inhibitors, severe sepsis, and infection-related outcomes in patients with chronic kidney disease and type 2 diabetes

Background: Patients with chronic kidney disease (CKD) and type 2 diabetes (T2D) are vulnerable to infections. While sodium-glucose cotransporter-2 (SGLT-2) inhibitors provide established cardiorenal benefits, their effects on infection remain unclear. This study aimed to evaluat...

A CD44-targeted PDA/ZnO redox-active nanocomposite that couples chemotherapy with mitochondrial stress and tumor immune remodeling

Bladder cancer therapy is frequently limited by inefficient drug retention and adaptive immune resistance within a hypoxic tumor microenvironment. Here, we report a CD44-targeted, fully synthetic nanocomposite (HPPZC) that converts chemotherapy into a mitochondria-associated ther...

The burden of suicide by paraquat poisoning in Taiwan (1987–2017): trends, geographic variations, and demographic characteristics

Pesticide self-poisoning accounts for 14%–20% of global suicides. Paraquat, a highly lethal pesticide, is involved in a considerable number of suicides in some countries. This study investigated the burden, trends, geographic variations, and demographic characteristics of pestici...

Polygenic architecture of childhood emotional and behavioral problems in East Asian youth: a multivariate genome-wide study

Abstract Background Emotional and behavioral problems in childhood, commonly classified as internalizing and externalizing symptoms, represent early manifestations of vulnerability to later psychiatric disorders. However, their genetic architecture remains largely characterized i...

IgG Glycosylation Patterns May Identify Distinct Clinical Trajectories in Fibromyalgia Patients: A Longitudinal Pilot Study

ABSTRACT Background Altered immunoglobulin G (IgG) glycosylation was implicated in various conditions, but its role in fibromyalgia (FM) remains unclear. This study investigated IgG glycosylation patterns in FM patients and associations between glycosylation changes and clinical...

The association between depression and frozen shoulder: A systematic review and meta-analysis

BackgroundFrozen shoulder (FS), commonly known as adhesive capsulitis, is a disabling musculoskeletal condition frequently accompanied by psychological distress. This meta-analysis aimed to evaluate the association between FS and depression.MethodsFor this meta-analysis, a system...

Safety and antiviral activity of inhaled siRNA SNS812 for treatment of mild-to-moderate COVID-19: a phase 2 randomized trial

Abstract Background SARS-CoV-2 remains a global health threat because ongoing viral evolution and immune evasion reduce the effectiveness of existing therapies. SNS812 is an inhaled small interfering RNA targeting a highly conserved region of the viral RNA-dependent RNA polymeras...

Same-day EHR-coded sevoflurane versus propofol exposure and long-term coded dementia in older surgical adults: a propensity-matched cohort study

Whether perioperative EHR records of sevoflurane and propofol identify clinically meaningful differences in long-term dementia risk is uncertain. We compared same-day EHR-coded sevoflurane versus propofol exposure in relation to subsequent coded dementia among older adults underg...

Systemic immune inflammation, physical function, and mortality in US adults: A prospective follow-up analysis of NHANES 2011 to 2014

Physical functional limitations and sleep disturbances frequently co-occur in older adults, yet their joint mortality risks and the potential nonlinear dynamics of systemic inflammation remain unclear. This study investigated the joint associations of health behavior profiles (ph...