Vrije Universiteit Amsterdam

Talquetamab for people living with relapsed/ refractory multiple myeloma: plain language summary of the MonumenTAL-1 study

Plain Language SummaryWhat is this summary about?This summary describes how well talquetamab worked and its safety at a median (midpoint) of 17–26 months follow-up from the MonumenTAL-1 study, which tested talquetamab treatment for a type of cancer called relapsed/refractory mult...

Feasibility of radiomics and deep learning methods for prognosis of non–small cell lung cancer using 18F-FDG PET/CT

Accurate prognostication for non-small cell lung cancer (NSCLC) is challenging due to tumor heterogeneity and the limitations of conventional PET biomarkers. This technical feasibility study compared the difference in prognostic performance of radiomics and deep learning (CNN) me...

Kids These Days! A Cross-Temporal Meta-Analysis of Changes in Emotional and Behavioral Problems of Population-Based Samples Over the Past Decades

Abstract There is a general belief that mental health problems are increasing in younger generations, though little objective comparisons exist. The current meta-analysis examines changes in subclinical mean-level overall symptom burden and shifts in specific domains among popula...

‘Like a light switch that is on and off at the same time’. A content analysis of signaled metaphors for quantum science and technology in Dutch newspapers

Quantum science and technology is an emerging field of research expected to have a transformative impact on society. Its inherent complexity and counterintuitive nature, however, may pose a barrier to communication with general audiences. Metaphors can play an important role in b...

Long-Term Health-Related Quality of Life Outcomes in Patients With Cellulitis Requiring Hospitalisation

In 94 hospitalised patients with cellulitis, HRQoL was markedly impaired at admission and remained significantly below population norms at 90 days, particularly in patients with persistent pain and oedema. These findings highlight the need for post-discharge follow-up focused on...

System-independent inequalities in youth justice decision-making: Seven spheres of influence

Children with social and health-related disadvantages are over-represented in youth justice systems in many countries. This phenomenon cannot be explained by offending rates alone; rather, a wide body of research suggests that inequalities in youth justice decision-making play a...

The LoVe score: Development and validation of a bedside clinical index to identify patients at risk for prolonged invasive mechanical ventilation

Background: Early management decisions after intubation, such as humidification strategy or initiation of prevention bundles for ventilator-associated pneumonia, often depend on the expected duration of invasive mechanical ventilation (IMV). However, no simple, standardised metho...

Boundary Spanning at Major Soccer Events: The Roles and Competences of Safety and Security Officers

This article is about the day-to-day boundary-spanning activities of safety & security officers (SSOs) employed by professional soccer organizations in the Netherlands. Drawing on Williams, we examined how SSOs perform their roles as reticulists, communicators, entrepreneurs, and...

Long-term outcomes of childhood ADHD stimulant use trajectories

Background. Stimulant medication is the first-line pharmacological treatment option for children with attention-deficit/hyperactivity disorder (ADHD). However, long-term effects remain unclear. Therefore, we explored long-term (>12 years) outcomes of childhood stimulant medicatio...

Underreporting loneliness among older adults: the role of gender, health, partner status, and migration background

Previous research suggests that people belonging to social categories not typically associated with loneliness are less likely to admit feeling lonely. Drawing upon this research, we hypothesized that men, those in good health, partnered individuals, and migrants are less likely...

Ocean Literacy and Blue Entrepreneurship in Vocational Education: A Systematic Bibliometric and Network Science Analysis

Background The transformation of the global marine economy towards a blue economy requires a workforce integrating marine literacy, technical competence, and entrepreneurial capacity. Although ocean literacy research has developed rapidly in general education, its engagement with...

Crossing margins: Intersectional users’ ethical concerns about software

Abstract Many modern software applications present numerous ethical concerns due to conflicts between users’ values and companies’ priorities. Intersectional communities, those with multiple marginalized identities, are disproportionately affected by these ethical issues, leading...

Daratumumab, lenalidomide, and dexamethasone in transplant-ineligible newly diagnosed multiple myeloma: MAIA final survival analysis

Abstract In previous analyses of MAIA, daratumumab plus lenalidomide/dexamethasone (D-Rd) significantly improved progression-free survival and overall survival (OS) versus lenalidomide/dexamethasone (Rd) in transplant-ineligible newly diagnosed multiple myeloma (NDMM). We report...

Best practices to master robotic preparation of ready-to-administer systemic anticancer therapy in hospital pharmacies

Automated reconstitution or preparation of systemic anticancer therapy has gained traction in the past decade. Transitioning from traditional manual workflows to fully automated production offers multiple benefits: decreased pharmacy staff workload, reduced risk of repetitive str...

The DGA of planar loops when 2n=4

Abstract The DGA of planar loops is a pictorial chain complex introduced in a recent paper of the author, Boyd, Randal‐Williams and Sroka, where a minimal model for it was given. In the first non‐trivial case, , we give a new model which incorporates two natural ‘reflection’ invo...

Rapid purity and charge-variant analysis of bispecific antibodies using microfluidic capillary electrophoresis-mass spectrometry

Bispecific antibody (BsAb) therapeutics have the ability to bind two targets simultaneously, which opens up new pathways for disease treatment. BsAbs consist of distinct heavy and light chains that need to be assembled correctly to form the appropriate heterodimer. However, durin...

ValuesML: A new multilingual dataset for values detection in news and political manifestos

Abstract Values are important building blocks of political ideologies and are frequently invoked in political debates. Yet, because values are abstract, understanding how they are expressed in real-world discourse, and how this varies across contexts, remains a challenge. In this...

Scaling Social Impact at Tony's Chocolonely: How Interactional Dynamics Shape Social Innovation Processes and Drive Institutional Change

Abstract Social enterprises are frontrunners in social innovation, yet our understanding of how they can scale their social impact beyond local, contained contexts remains nascent. To transform the institutional environment that gives rise to social problems, social enterprises m...

Tiny Droplets, Large Insights: Studying Peptide Aggregationwith Droplet-Based Microfluidics Hyphenated with Ion Mobility MassSpectrometry

Abstract Peptide and protein aggregation are hallmarks of numerous neurodegenerative diseases. However, the structural characterization of oligomeric intermediates remains challenging due to their low abundance, heterogenic nature, and complexity of coinciding and transient react...

Explaining gender differences in the associations between care network type and depressive symptoms of older adults in the Netherlands

The association between long-term care use and mental health is ambiguous: informal care is generally negatively related to depressive symptoms, while formal care use is positively associated. As both care use and mental health are highly gendered, this study explored gender diff...