Vrije Universiteit Amsterdam

Sequential Dual Catalysis Merging Enantioselective Cu-Catalyzed Conjugate Addition with Intramolecular Pd/Ir-Catalyzed Allylic Alkylation

The combination of asymmetric conjugate addition and allylic alkylation has emerged as a powerful strategy for the stereocontrolled construction of complex molecules. However, such transformations have been largely limited to intermolecular processes and have not been explored on...

Brief video-feedback training enhances childcare professionals’ interaction skills: A cluster randomized controlled trial

High-quality caregiver–child interactions are central to children’s development in early childhood education and care (ECEC) settings. Professional development programs have been shown to improve caregivers’ interactional skills, but evidence from large randomized controlled tria...

Exploring Career Competencies: An Italian Validation Study of the CCQ and Test of Its Nomological Net

Career competencies are widely acknowledged as critical self-regulatory resources for achieving career success. The measurement of career competencies has been largely confined to restricted cultural contexts, limiting theoretical development and practical application. Addressing...

Quaternion Dirac–Coulomb–Breit integral transformation for relativistic four-component correlated electronic structure theory

High-accuracy correlated four-component relativistic electronic structure methods are typically formulated in terms of integrals over molecular orbitals (MOs). Consequently, an efficient and scalable strategy is required to deal with the complexity of transforming relativistic tw...

Bidirectional Phase Sensitivity in Holographic Phototransient Microscopy

Abstract Mid-infrared photothermal microscopy combines the chemical specificity of infrared absorption with the spatial resolution of visible light detection, but practical implementations face a persistent trade-off between forward-scattering (FWS) and backward-scattering (BWS)...

District-level analysis of temperature-related excess mortality in the Netherlands

Background: While most epidemiological studies have assessed temperature–mortality associations at broad geographical scales, recent research highlights that temperature-related mortality risks are spatially heterogeneous due to local differences in exposure, vulnerability, and a...

Home-based geriatric rehabilitation after shortened inpatient rehabilitation: cost-effectiveness analysis of the “Better@Home” multicentre prospective cohort study with a matched historical control group

PURPOSE: Geriatric rehabilitation (GR) is facing increased demand due to population ageing. Home-based GR could reduce reliance on resource-intensive inpatient care. However, evidence is limited regarding the cost-effectiveness of home-based GR. The aim of this study is to assess...

Love Without Borders: Explaining Why People Interact with National Out-Groups on Tinder

Despite our tendency to select romantic partners who are similar to us, a growing body of research seems to suggest that online dating may increase the diversity of couples. However, to this day, there is no clarity around what might drive users to cross social boundaries on thes...

Introducing a new normalized cryospheric index (NCI) to categorize sub-watersheds on arid environments

Abstract. This study examines sub-watersheds in the arid northern region of Chile (26°41’–28°24’S), situated within the broader Copiapo watershed. The primary water source for this watershed originates from cryospheric reservoirs. The region exhibits pronounced physiographic and...

“Now You Know, Don't Be Indifferent”: The Emotional Correlates of Learning About Historical Violence and Their Relationship With Current Prosocial Motivation

ABSTRACT How does learning about historical violence inspire prosocial action today? Prior work has focused on whether such experiences are (emotionally) impactful but seldom tested the mechanisms of impact. We propose a framework of actor‐specific emotional pathways connecting k...

ADHD symptoms and learning difficulties: co‐occurrence and directionality from Grades 1 to 9

Background Children with attention‐deficit/hyperactivity disorder (ADHD) are at increased risk of learning difficulties. This association may reflect shared risk factors, ADHD symptoms hindering learning, or learning difficulties increasing ADHD symptoms. We aimed to map rates of...

A living systematic review, meta-analysis, and open data resource of trials of MDMA-assisted therapy for PTSD

Abstract 3,4-Methylenedioxymethamphetamine (MDMA) has emerged as a potential treatment for post-traumatic stress disorder (PTSD). However, rapidly changing evidence in a fast-moving field can be challenging to integrate. Here, we present a living systematic review and open-data m...

The impact of the COVID-19 pandemic on institutionalization and healthcare costs in memory clinic patients

Background The COVID-19 pandemic disrupted healthcare services and daily routines, which may have particularly affected individuals with cognitive impairment or dementia who rely on continuity of care. However, the impact of these disruptions on institutionalization and healthcar...

Beyond the Lockdown: Long-Term Impact of COVID-19 on Registered Domestic Violence in the Netherlands

Domestic violence is a pervasive societal issue impacting millions of people worldwide. While numerous studies have examined the short-term impact of the COVID-19 restrictions on domestic violence, research on its long-term effects remains limited. This study aims to explore the...

Prevalence and associated risk factors of anal high-risk human papillomavirus infection in unvaccinated young men who have sex with men visiting the Center of Sexual Health of Amsterdam

Background: Anal high-risk human papillomavirus (hrHPV) is highly prevalent among men who have sex with men (MSM) and the main cause of anal cancer. The effectiveness of HPV vaccination in this population is highly dependent on prior HPV exposure. We aimed to assess the prevalenc...

MAIA frailty subgroup analysis: long-term follow-up with daratumumab plus lenalidomide/dexamethasone in transplant-ineligible newly diagnosed myeloma

Abstract In MAIA (Daratumumab, lenalidomide, and dexamethasone versus lenalidomide and dexamethasone alone in newly diagnosed multiple myeloma), daratumumab plus lenalidomide/dexamethasone (D-Rd) improved progression-free survival (PFS) and overall survival (OS) versus Rd in tran...

Breaking the methodological silos: Integrating Mixed-Methods in Multi-Hazard Risk Assessment Lessons learnt from fieldwork in Tenerife

This essay explores the advantages and limitations of using mixed-methods approaches to improve local multi-hazard risk (MHR) assessment and its inherent complexities. By combining desktop analysis, field observations, questionnaires and stakeholder interviews, we demonstrate how...

Whole-genome 5-hydroxymethylation profiling of human neurons for regulatory and biological insight

Abstract While 5-methylcytosine (5mC) DNA methylation is a well-known player in genome stability and transcriptional regulation, the role of 5-hydroxymethylcytosine (5hmC), particularly prevalent in neurons, remains largely unknown. Here, we used long-read Oxford Nanopore Technol...

Against speech liberalism for generative AI

Abstract Speech liberalism holds that the linguistic output of generative AI is continuous with human speech and should therefore be treated as meaningful in broadly the same way. Strong versions of this view take the fluent behaviour of chatbots to justify attributing genuine li...

May we tighten the screws? An experiment on public acceptance of pressure during police interrogations

Abstract Purpose Many countries have vague limits on how much pressure police may use during interrogations. This leaves room for tactics that increase the risk of false confessions, such as lying about the evidence. Public opinion seems to oppose ‘friendly questioning’, which ma...