Vector & Vector-Borne Diseases Research Institute

Rapid Clinical Improvement Temporally Associated with Off-Label LetiFend® Vaccination in Canine Leishmaniasis: A Case Report

Canine leishmaniasis (CanL), caused by Leishmania infantum, can be difficult to manage in dogs with severe clinical disease, particularly when established treatments are impractical or poorly tolerated. We report an approximately 3-year-old mixed-breed dog from Sardinia with clin...

Lithium Ascorbate May Support Weight Loss Within the Depression-Obesity Feedback Loop

Depression and obesity frequently coexist and may reinforce one another through biological, behavioral, and psychosocial mechanisms, complicating both mood management and weight reduction. This paper reviews the depression–obesity feedback loop, current approaches to major depres...

A dimeric mRNA vaccine based on key-mutant and KP.3 RBDs induces broad-spectrum immunity and protects mice against JN.1 and XDV challenges

The continued antigenic evolution of SARS-CoV-2 Omicron subvariants has progressively eroded vaccine-elicited protective immunity, driving demand for next-generation candidates that confer broad-spectrum protection against phylogenetically divergent strains. Here we report the de...