Institution
Vanderbilt University
Recent research
- Health & Medicine
Abstract Topic Esophageal Cancer: Other Background Anastomotic leak remains a major complication in esophagectomy. Indocyanine Green (ICG) can assist with the assessment of conduit perfusion but remains subjective and prone to bias. Our lab has worked to design a computer vision...
- BiologyOpen access
Advancements in transmission electron microscopy (TEM) have enabled in-depth studies of biological specimens, offering new avenues to large-scale imaging experiments with subcellular resolution. Mitochondrial morphology is of growing interest in cancer biology due to its crucial...
- Health & MedicineOpen access
Enhancement of cytokine-mediated beta-cell apoptosis by free fatty acids
Type 1 diabetes (T1D) results from dysfunction and loss of the insulin-producing pancreatic β cells. The body’s lipid metabolism is strongly regulated during this process but there is a need to understand how this regulation contributes to the β-cell death. Here, we investigated...
- Health & MedicineOpen access
Student Perceptions on Educational Handovers from Medical School to Residency
Abstract To improve the transition to residency, the Coalition for Physician Accountability recently recommended a post-Match, learner-driven educational handover. Few studies have analyzed students’ perspectives on the content of handovers, especially the inclusion of personal v...
- Health & MedicineOpen access
Integrated Supports: Perspectives from Adults with Intellectual and/or Developmental Disabilities
Abstract All individuals need supports throughout their lives. Individuals with intellectual and/or developmental disabilities (IDD) may rely on integrated supports – a combination of formal (i.e., paid supports provided by service providers) and natural supports (i.e., unpaid su...
- Health & Medicine
What’s Old Is New Again: Varicella
The availability of a varicella vaccine has led to significant decreases in incidence of this once-common childhood disease. In the setting of rising vaccine hesitancy, health care clinicians are now more frequently facing questions about infections caused by varicella zoster vir...
- BiologyOpen access
Certain forms of mitochondrial impairment confer longevity, while disease-associated mitochondrial dysfunction triggers pathogenesis. The adaptive pathways that distinguish benefit from pathology remain unclear. Here we reveal that longevity induced by mitochondrial Complex I/nuo...
- Health & MedicineOpen access
ABSTRACT Background Ocular fungal infections are a major cause of vision loss worldwide. Fusarium spp., a leading cause of fungal keratitis, is often difficult to treat. There are no current standardized treatment guidelines for fungal keratitis. We present a case of Fusarium spp...
- BiologyOpen access
Dynamic cellular programs of human cardiac allograft rejection revealed by spatial transcriptomics
Abstract Allograft rejection following solid-organ transplantation is a major cause of graft dysfunction and mortality. Current diagnostic approaches rely on histology, which exhibits wide diagnostic variability and lacks clinically relevant molecular phenotyping. Here we leverag...
- Society & EconomicsOpen access
Firearm carrying practices and motivations: A mixed methods study among adults and youth
Abstract The purpose of this participatory action, mixed methods research study was to identify motivations related to firearm carrying from a qualitative perspective, and then to use quantitative research to characterize the patterns of motivations around carrying. Qualitative i...
- Society & Economics
RDoC-informed research on the anxiety disorders: best practices and future directions
This article outlines recommended approaches for future Research Domain Criteria (RDoC)-driven research on anxiety disorders that are aligned with the National Institute of Mental Health's translational aims. It discusses 'intermediary' psychological processes, multidimensional s...
- Health & MedicineOpen access
Families' experience of homelessness is typically examined from the perspective of parents during or shortly after a shelter stay. Parents complain about rules, surveillance, crowding, and challenges to parenting in both homeless shelters and in doubling up with other households...
- Health & Medicine
Actinoplanes teichomyceticus is a well‐established producer of bioactive secondary metabolites, including the glycopeptide antibiotic teicoplanin. Although its antibiotic biosynthetic capacity has been extensively investigated, its siderophore diversity and any additional biologi...
- BiologyOpen access
Prioritizing clinical utility to use allostatic load as a biomarker of the consequences of stress
Allostatic load measures the physiological consequences of stress and is associated with disease outcomes. Clinical use of allostatic load is limited, in part, because its calculation requires biomarkers not routinely measured in clinical care. Presently, we evaluated association...
- Health & Medicine
Bridging Practice and Publication: Reexamining Quality Improvement in Pediatric Scholarship
Quality improvement (QI) publication rates in pediatrics surged through the early 21st century yet have noticeably plateaued since that time, a paradoxical shift given the volume of ongoing improvement work across pediatric health systems. We propose that the gap lies not in the...
- Society & EconomicsOpen access
ABSTRACT Sleep disorders are rising globally, but their lifestyle causes remain unclear. We recorded sleep-wake patterns via actigraphy from 1036 Orang Asli adults across 12 communities in Peninsular Malaysia undergoing market integration, marked by changes in permanent infrastru...
- Health & Medicine
Hantavirus Infections in Children
Hantaviruses are rare but deadly pathogens. New World hantaviruses, primarily present in North and South America, cause hantavirus cardiopulmonary syndrome, which leads to death in up to one-third of affected patients. Old World hantaviruses, primarily endemic to Europe and Asia,...