Vanderbilt Health

Physically interacting immune cells in cardiometabolic disease: established platelet-immune aggregates and emerging leukocyte-leukocyte complexes

Chronic immune activation contributes to cardiometabolic disease and has most often been attributed to soluble mediators or changes in individual immune-cell subsets. A complementary dimension of immune organization is captured by direct physical interactions between immune cells...

Development and Preliminary Feasibility Testing of PACERS , a Physical Activity‐Centered Intervention for Rural Older Adults With Hypertension

BACKGROUND: A high prevalence of hypertension is observed among American rural residents. This study aimed to engage rural community members in designing, developing, and preliminarily testing the feasibility of a physical activity (PA)-centered health promotion intervention inte...

Per- and polyfluoroalkyl substances levels other than PFOS, PFOA, or PFHxS and liver cancer risk: a nested case-control analysis

Abstract Epidemiologic studies of PFAS and liver cancer risk have produced conflicting results with no strong or clear associations for pre-diagnostic perfluorooctanesulfonate (PFOS), perfluorooctanoate (PFOA), and perfluorohexanesulfonate (PFHxS). We now report analyses of nine...

National Outcomes of Sepsis in Publicly Insured Children: 2021–2023

OBJECTIVE To identify incidence and factors associated with sepsis mortality. METHODS We conducted a cohort study of all US publicly insured children younger than age 19 years hospitalized with a diagnosis code–based definition of sepsis in 2021–2023 using the Transformed Medicai...

Composition and size of close social networks among older adults in same-sex and different-sex couples

Abstract Objectives This study examines differences in the composition and size of the close social network among older adults in same-sex and different-sex coresidential unions. Methods Using pooled, probability-based, cross-sectional data from the 2006–2022 Health and Retiremen...

Management strategies in endogenous fungal endophthalmitis: a multi-institutional retrospective cohort study

Background/aims Standardised treatment guidelines for endogenous fungal endophthalmitis (EFE) are lacking. The purpose of this study is to describe treatment strategies and clinical outcomes of eyes with EFE. Methods Retrospective cohort study performed at eight academic institut...

Designing multi‐site studies for external validity: Site selection via synthetic purposive sampling

Abstract Multi‐site/context studies have become popular strategies to address the most common and challenging external validity concerns about contexts. Under such studies, scholars conduct causal studies in each site and evaluate whether findings generalize across sites. Despite...

Fusarium falciforme keratitis in a corneal transplant recipient treated successfully with fosmanogepix and intracameral amphotericin B

ABSTRACT Background Ocular fungal infections are a major cause of vision loss worldwide. Fusarium spp., a leading cause of fungal keratitis, is often difficult to treat. There are no current standardized treatment guidelines for fungal keratitis. We present a case of Fusarium spp...

Identification of Siderophores With Unexpected Antibacterial Properties From Actinoplanes teichomyceticus

Actinoplanes teichomyceticus is a well‐established producer of bioactive secondary metabolites, including the glycopeptide antibiotic teicoplanin. Although its antibiotic biosynthetic capacity has been extensively investigated, its siderophore diversity and any additional biologi...

Guns and Perceptions of Safety Among US Women

Importance: Prior research found differences in the perceived safety benefits from firearm exposure among diverse gun owners. More women have bought firearms in recent years, resulting in a growing proportion of women who own guns. Objective: To examine differences in perceptions...