Institution
VA Tennessee Valley Healthcare System
Recent research
- Health & MedicineOpen access
Chronic immune activation contributes to cardiometabolic disease and has most often been attributed to soluble mediators or changes in individual immune-cell subsets. A complementary dimension of immune organization is captured by direct physical interactions between immune cells...
- Health & Medicine
Clarifying the Concept of “Unanticipated Transfer to the ICU”: A Scoping Review
Unanticipated transfer to the intensive care unit (ICU), typically defined as an unscheduled escalation of care from inpatient general wards, is widely used in clinical research as a marker of adverse events, clinical deterioration, and system failure. However, its conceptual mea...
- Health & Medicine
BACKGROUND: A high prevalence of hypertension is observed among American rural residents. This study aimed to engage rural community members in designing, developing, and preliminarily testing the feasibility of a physical activity (PA)-centered health promotion intervention inte...
- Health & Medicine
BACKGROUND: Understanding changes in quality of life that occur with colectomy is critical to decision-making in management of recurrent diverticulitis. We hypothesized that patients choosing colectomy at surgical consultation would report better disease-specific quality of life...
- Health & Medicine
Early-life colonization with Clostridioides difficile remodels the developing gut
Clostridioides difficile causes severe disease in adults but commonly colonizes infants asymptomatically. The consequences of early-life colonization on host development remain unknown. In a neonatal mouse model, C. difficile colonization drove proinflammatory and tissue repair r...
- Health & Medicine
Statins Use in Veterans With Peripheral Artery Disease: Insights From the PEARLS Study
BACKGROUND: Guidelines recommend high-intensity statins in patients with peripheral artery disease (PAD). We examined contemporary use of statins among real-world patients with a new diagnosis of PAD. METHODS: Within a national registry of Veterans with incident PAD, we used phar...
- Health & MedicineOpen access
OBJECTIVE: To evaluate whether adding cancer and histoplasma biomarkers to existing clinical prediction models improves diagnostic accuracy for malignancy in indeterminate pulmonary nodules (IPNs). SUMMARY BACKGROUND DATA: IPNs remain a diagnostic challenge, particularly in regio...
- Health & MedicineOpen access
Abstract Purpose Down syndrome regression disorder (DSRD) is a condition occurring in young people with Down syndrome. It is associated with functional decline, new onset psychopathology, and increased support needs. DSRD is often associated with catatonia, for which electroconvu...
- Health & MedicineOpen access
The American Board of Internal Medicine Research Pathway (ABIM RP) is designed to train physician-scientists by shortening postgraduate clinical training and increasing research time. We surveyed ABIM RP graduates to understand career trajectories, research engagement, and barrie...
- Health & Medicine
Implementation of a pilot online educational program to identify paramagnetic rim lesions
Background: Paramagnetic rim lesions are a highly specific magnetic resonance imaging biomarker for multiple sclerosis now incorporated into the 2024 McDonald Criteria. However, paramagnetic rim lesion identification remains underutilized in clinical practice. This study evaluate...
- Health & Medicine
BACKGROUND: Treatment for alcohol and opioid withdrawal when managed independently is well-established; however, specific guidance on their concurrent management is lacking. This review evaluated the relationship between buprenorphine initiation and time to initiation on key subs...