VA Boston Healthcare System

Transcriptome signatures associated with cognitively unimpaired individuals with pathologically confirmed Alzheimer disease

There is growing interest in cognitive resilience to Alzheimer’s disease (AD), given limited success of therapies targeting hallmark proteins. Gene expression in the prefrontal cortex region obtained from brain donors in three cohorts was compared among pathological controls and...

Navigating physician-scientist careers: insights from American Board of Internal Medicine Research Pathway graduates

The American Board of Internal Medicine Research Pathway (ABIM RP) is designed to train physician-scientists by shortening postgraduate clinical training and increasing research time. We surveyed ABIM RP graduates to understand career trajectories, research engagement, and barrie...

Data-driven prediction of fifteen-year all-cause mortality among 2.3 million individuals in the VA

ABSTRACT We present a data-driven framework to predict 15-year all-cause mortality using outpatient administrative records for 2.3 million Veterans in the largest integrated U.S. healthcare system. Rather than relying on predefined clinical phenotypes, we used the 1,000 most comm...

Proteomic analysis of human chronic traumatic encephalopathy brain implicates proteasome and ribosome dysfunction in disease severity

Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease that occurs in individuals with repeated head impacts (RHI) exposure, including contact sport athletes, military personnel, and domestic abuse victims. Despite growing recognition of CTE, the molecular mechanis...

Adoption and diffusion of SGLT2 inhibitors among cardiologists in medicare part D, 2019–2023: a provider-level observational study

Abstract Background Sodium–glucose cotransporter-2 (SGLT2) inhibitors are guideline-directed therapies for heart failure, yet real-world diffusion into cardiology practice remains incompletely characterized. This study evaluated adoption, prescribing intensity, subspecialty varia...

Survey Authentication Challenges During a Geriatrics Knowledge Assessment Pilot

ABSTRACT Background In this methodological Brief Report, we describe a multi‐institutional survey authentication challenge encountered during pilot deployment of the Age‐Friendly Knowledge Assessment Tool (AF‐KAT), a geriatrics knowledge assessment for graduating medical students...