University of Wisconsin System

Proteoforms in Disease: Biomedical Applications of Top‐Down Proteomics

ABSTRACT The proteome is a dynamic landscape of proteoforms arising from genetic mutations, alternative splicing, and post‐translational modifications (PTMs), which collectively drive biological function and disease phenotypes. Mass spectrometry (MS)‐based proteomics has emerged...

The Causal Effect of Parents' Education on Children's Earnings

ABSTRACT We develop and estimate a model of endogenous schooling and earnings to isolate the causal effect of parents' education on children's outcomes. Identification uses earnings differences among children with equal schooling whose parents have different schooling. Health and...

Biased inter-columnar communication and short-term plasticity in mouse barrel cortex

Abstract The barrel cortex (BC) processes complex direction-, frequency-, and phase-dependent input from whiskers to analyze objects in the immediate environment. Little is known about how BC microcircuits process this information and integrate input from multiple whiskers. To in...

Local Linear Estimation for Covariate‐Dependent Coefficients Model in Disease Mapping

ABSTRACT Spatial regression effects may depend on covariates in disease‐mapping models. For example, the association between infectious disease incidence and risk factors may vary according to climatic factors, such as time, season, and temperature. In this study, we aim to devel...

Tunable Polariton Canalization in Natural Van Der Waals Oxide

ABSTRACT Hyperbolic phonon polaritons (HPPs) are coupled oscillations of anisotropic lattice vibrations and electromagnetic fields that confine the latter to the nanoscale, enabling novel nano‐polaritonic devices. While HPPs have been identified in multiple layered materials, ach...

Little Red Dots host Black Hole Stars: A unified family of gas-reddened AGN revealed by JWST/NIRSpec spectroscopy

Abstract We construct and characterise a sample of 146 little red dots (LRDs) across 2.0 < z < 9.3, selecting all sources with v-shaped UV-optical continua from JWST NIRSpec/PRISM spectra and compact morphologies in NIRCam/F444W imaging. We show that LRD continuum spectra are wel...

Genome-wide CRISPR screening identifies cellular factors controlling nonviral genome editing efficiency

After administering genome editors, their efficiency is limited by a multi-step process involving cellular uptake, trafficking, and nuclear import of the vector and its payload. These processes vary widely across cell types and differ depending on the nature and structure of the...

The evolution of plasticity in drought-related traits in central and edge populations of Mimulus cardinalis

Phenotypic plasticity can influence population persistence, range dynamics, and evolutionary potential in heterogeneous landscapes. If adaptive, plasticity may buffer populations against environmental variability, climate change, and extreme events. Yet, few studies have examined...

Prevalence and Clinical Characteristics of Vitiligo-Associated Hearing Loss Among Patients in a Phase 2 Clinical Trial of Povorcitinib

Patients with vitiligo reportedly have an increased risk of sensorineural hearing loss (SNHL), driven by the loss of extracutaneous melanocytes in the inner ear. In a phase 2 dose-ranging study, the oral, selective Janus kinase 1 inhibitor povorcitinib demonstrated substantial re...

Isolation of Phytoecdysteroids:Ajugasterone C and20-Hydroxyecdysone, from Sida alba Linn.

Abstract Medicinal plants are employed in folk medicine as enormous reservoirs of secondary metabolites, with varied and distinctive chemical and biological properties, that can prevent, treat, or cure diseases. Consequently, the validation of traditional remedies has remained a...

A multi-ancestry polygenic risk score for body mass index predicts longitudinal weight change

Abstract Background Identifying individuals at risk for future weight gain is challenging, partly because associations with traditional clinical risk factors may be biased by confounding and reverse causation. Polygenic risk scores (PRS) provide a stable, lifelong measure of gene...

Structure-Based Insights into the Molecular Mechanisms of LuxR-Type Quorum Sensing Receptors

Quorum sensing (QS) enables bacteria to coordinate collective behaviors in response to population density. LuxI/R QS systems, common among gram-negative bacteria, consist of a LuxI-type synthase that produces an N- acyl L -homoserine lactone (AHL) signaling molecule and a LuxR-ty...