University of Verona

Burdock (Arctium lappa L.) Root Extract Induces Transcriptional Signatures Associated with Metal Homeostasis and Lipid Metabolism in Human Keratinocytes

Background/Objectives: Botanical metabolites can modulate cellular stress responses, lipid homeostasis, and epithelial organization. Arctium lappa L. (Burdock) root contains bioactive phytochemicals and inulin-type fructans, but its molecular effects in vitro remain incompletely...

What are the knowledge, use, and perceived benefits and limitations of artificial intelligence chatbots among Italian nursing students? A cross-sectional multicentre study

Exploring students’ knowledge, use, and perceptions of Artificial Intelligence (AI) chatbots may inform strategies in the educational context. However, limited evidence is available on Italian nursing students, leaving this field largely unexplored. A cross-sectional online surve...

The Flying Phase in Sprint Runners: Exploring Biomechanical Factors Associated With Performance

Abstract Faggian, S, Lei, LW, Ghezzo, E, Bucciol, M, Airale, M, Del Giudice, M, Breban, SG, Bozzato, M, Costa, I, Cutti, AG, Petrone, N, and Marcolin, G. The flying phase in sprint runners: Exploring biomechanical factors associated with performance. J Strength Cond Res XX(X): 00...

QTc changes and early major adverse cardiovascular events associated with antidepressant treatment for major depressive disorder in adults: individual participant data network meta-regression of double blind randomised trials

Abstract Objective To compare the effect of specific antidepressants with placebo on heart rate corrected QT interval (QTc) during the first eight weeks of treatment for major depressive disorder in adults, and to investigate whether antidepressant use is associated with early ma...

Melatonin beyond chronobiology: integrating pharmacokinetics, dose-exposure forecasting, and clinical evidence

Abstract Melatonin is established as a regulator of circadian timing and sleep, while a wider range of receptor-dependent and receptor-independent biological effects has generated interest in additional therapeutic applications. This review critically examines whether those propo...

Vitamin D in coronary heart disease: a Mendelian randomization meta-analysis of data stratified by 25(OH)D levels

Maria Fusaro, Pasquale Perrone Filardi, Gianfranco Sinagra, Maria Luisa Brandi, Maurizio Gallieni, Jean-Yves Reginster, Eugene McCloskey, Etienne Cavalier,

The PancreaSure Multianalyte Blood Test Performs Well at Distinguishing Early-Stage Pancreatic Ductal Adenocarcinoma from High-Risk Controls: A Retrospective Secondary Analysis

Background/Objectives: Biomarkers that can facilitate early detection of pancreatic cancer and extend patient survival are a significant unmet need. PancreaSure is a serum biomarker signature that performed well at distinguishing Stage I and II pancreatic ductal adenocarcinoma (P...

The future of allergy and immunology care: A perspective on innovation, equity, and global collaboration from the WAO Junior Members Group

Allergic and immunological diseases are among the fastest-growing non-communicable conditions worldwide, affecting all age groups and regions.1 The increasing burden of asthma, allergic rhinitis, atopic dermatitis, food allergy, and other immune-mediated conditions is driven by c...

Upfront surgery vs. neoadjuvant therapy in pancreatic cancer with venous involvement: a multicenter retrospective analysis

Abstract Introduction The benefits of neoadjuvant therapy (NAT) for pancreatic cancer (PC) with portal venous involvement remain debated. This study aimed to compare the short- and long-term outcomes of surgery with or without NAT in patients with PC with suspected venous involve...

A walk down memory lane: How memories influence stock investment and information processing

Propensity to invest in stocks is highly heterogeneous, with many households avoiding stock market participation altogether. This heterogeneity is difficult to reconcile with standard economic theory. We study the role of memories in shaping investment decisions and in influencin...

Using Match Reference Values of External Load to Monitor Performance and Fatigue in Football: Are We Looking the Right Way?

Abstract Monitoring external load is critical for informed decision-making processes across sports. In football, external load is routinely monitored during training sessions and competitive matches. Matches are typically given particular emphasis, as they are generally associate...

Survival benefit of deceased donor kidney transplantation versus continued dialysis: international target trial emulation

Abstract Objective To quantify the survival benefit of deceased donor kidney transplantation versus continued dialysis according to patients’ characteristics (age, diabetes, cardiovascular disease), donor quality (standard criteria donor or expanded criteria donor) and donor retr...

Infinitary negative translations and Glivenko logic

Abstract We study infinitary intuitionistic logic by employing both syntactic and semantic methods. First, we introduce a natural deduction system for infinitary predicate logic and study some of its basic properties. We then extend neighbourhood semantics to this setting, provid...

Percentile-Based Normative Standards for Strength Assessment Beyond Linear Bodyweight Multipliers in Competitive Powerlifters

Abstract Background Bodyweight multipliers (BM = L/M, where L denotes the absolute load lifted in kilograms and M the athlete's recorded body mass) represent the dominant benchmarking heuristic in strength and conditioning. However, because relative strength declines non-linearly...

Antidepressants and breast cancer risk: a meta-analysis of exposure windows and cumulative use in nearly two million women

Abstract Background The use of antidepressants is steadily increasing worldwide. This trend has a significant impact on public health and socioeconomic conditions. Although studies have looked for a possible link between antidepressants and breast cancer risk, findings remain unp...

Clinical, Microbiological and Genomic Characterization of OXA-48-Producing Klebsiella pneumoniae ST395 Circulating in a Secondary-Care Hospital in North-Eastern Italy, 2024–2025

Background/Objectives: This study aimed to characterize the epidemiology, resistance, virulence determinants, and genomic relatedness of OXA-48-producing Klebsiella pneumoniae in a secondary-care hospital in north-eastern Italy, and to assess the in vitro activity of cefepime-bas...

Market size and strategic interaction in pharmaceutical price regulation

Abstract We present a model of optimal regulation in the presence of spillover effects and asymmetric countries, and we use it to study strategic interaction among countries in pharmaceutical price regulation, where the spillovers result from innovation in drug development. Regul...

GRASP: a plant transformation-independent CRISPR-based system for affinity purification of specific chromatin loci

ABSTRACT Chromatin organization regulates genome stability and gene expression by controlling DNA accessibility to transcription factors and regulatory complexes. DNA-protein interactions are commonly investigated using chromatin immunoprecipitation (ChIP), which relies on specif...

Transcriptome Dynamics From Primary Gastric Cancer to Peritoneal Metastases: Translational Insights for Surgical Oncology

BACKGROUND AND AIMS: Peritoneal metastases (PMs) represent the most frequent, clinically challenging dissemination pattern in advanced gastric cancer, especially poorly cohesive (PCGC) subtype, and are associated with poor prognosis. We aimed to characterize the transcriptomic la...

Variation in meningioma recurrence risk estimates across observational cohorts: the influence of calendar time, WHO classifications, geographical settings, and healthcare systems

Abstract Purpose Recurrence risk estimates underpin meningioma research, including molecular classification and clinical trial benchmarking, yet are often based on retrospective or historical data. The aim of this study was to assess the variation of recurrence risk estimates acr...