University of Tsukuba

Dual-oxygen pancreatic cancer organoids recapitulate basal–classical heterogeneity validated by spatial transcriptomics

Pancreatic ductal adenocarcinoma (PDAC) comprises heterogeneous classical and basal-like subtypes. Although pancreatic cancer organoids (PCOs) are widely used, normoxic cultures preferentially maintain the classical subtype, limiting their ability to represent intrinsic intratumo...

Extended global area search algorithm for unimolecular reactions and multistep conformational transitions

In this study, we propose an extended Global Area Search (GLAS) algorithm for the automatic exploration of multistep transitions without specifying reaction coordinates in advance. The key concept of the original GLAS method is to introduce repulsive interactions among walkers re...

A Gradient-CorrectedPolarizable Continuum Model forImproved Reaction Fields at the SCF Level

Abstract We propose an improved model, termed the gradient-corrected PCM (GCPCM), for improving the energy accuracy of the polarizable continuum model (PCM). Our previous study revealed deficiencies of PCM in describing the reaction field, i.e., the electrostatic potential genera...

Stump-related embolism from a thrombosed carotid–subclavian bypass causing large vessel occlusion after thoracic endovascular aortic repair

Background: Kommerell diverticulum frequently requires thoracic endovascular aortic repair (TEVAR) with carotid–subclavian bypass (CSB). Although CSB is durable, delayed embolic stroke secondary to graft failure is rare. We report a rare case of large vessel occlusion caused by a...

Associations between jump-derived mechanical indicators and sprint performance across sprint sections in baseball players

The purpose of this study was to examine the relationships between sprint performance across discrete distance sections and mechanical indicators derived from ballistic and reactive jumping tasks in male collegiate baseball players. Sixty-two players performed maximal 40-m sprint...

Multidimensional Social Interaction and School Refusal Tendency Among Elementary and Junior High School Students: A Three-Year Longitudinal Study with an Exploratory Indirect-Association Analysis

Background/Objectives: School refusal tendency is an important school adaptation issue, but its upstream psychosocial correlates remain insufficiently understood. We examined whether baseline multidimensional social interaction was prospectively associated with later school refus...

Building a Physics-Aware AI Ecosystem for Solid-State Hydrogen Storage Materials

Abstract Hydrogen storage remains a central bottleneck for scalable hydrogen energy systems due to the multiscale and coupled nature of the thermodynamics, kinetics, and microstructural evolution of hydrogen storage materials (HSMs). Although artificial intelligence (AI) has acce...

High-Spatial-ResolutionNear-Infrared ThermographyUsing an Uncooled Silicon-Based Camera

Abstract The demand for noncontact temperature measurements is growing as the microelectronic features to be probed become progressively smaller. However, traditional thermal imaging with infrared cameras is fundamentally constrained by the micron-long wavelength of thermal emiss...

Tracking the baryon number with nuclear collisions

Baryon quantum number is found to be conserved since baryogenesis in the early Universe. Conventionally, each fractionally charged valence quark is understood to carry one-third of a baryon number. An alternative hypothesis posits that baryon number is instead carried by a baryon...

Artificial hibernation reveals synaptic engram architecture associated with memory retention

Memories leave lasting physical changes at the synaptic level. Although stable, larger spines are thought to support memory, the high turnover of dendritic spines and the drifting of neuronal representations after memory formation suggest alternative possibilities. To elucidate t...

Prognostic Value of One-Month Postoperative ICIQ-SF Score for Six-Month Urinary Continence After Robot-Assisted Radical Prostatectomy

Background/Objectives: Urinary incontinence after radical prostatectomy remains a significant concern affecting postoperative quality of life. This study aimed to investigate whether the early postoperative International Consultation on Incontinence Questionnaire-Short Form (ICIQ...

Machine-Learning Analysis of the Electronic Structure of Atomically Thin MnTe Films from Scanning Tunneling Spectroscopy

Layered two-dimensional (2D) van der Waals magnetic crystals based on 3d transition metals and chalcogenides are typically synthesized by chemical vapor transport, while establishing epitaxial, layer-by-layer growth under vacuum remains essential for device applications. Here, we...

Gut microbial and metabolic biomarkers for early-onset colorectal cancer

Early-onset colorectal cancer (EO-CRC) is a growing global health challenge with poorly understood etiology. While gut microbiota and metabolites are implicated in colorectal carcinogenesis, EO-CRC-associated signatures remain poorly characterized. This study presents the first l...

Real-world safety and effectiveness of olaparib maintenance after first-relapse platinum-sensitive ovarian cancer in Japan: a multicenter historical cohort (JGOG3026)

OBJECTIVE: The primary objective of the study was to evaluate the safety and effectiveness of olaparib maintenance therapy in Japanese patients with platinum-sensitive first-relapsed ovarian cancer. The secondary objective was to survey the treatment given after the olaparib main...

Spatial control of PEG-lipid interfaces at cell surface enables on-demand adhesion and enzymatic detachment of suspension cells

Suspension cells are widely used in biomedical research and cell-based therapies; however, their lack of stable adhesion to substrates limits their efficient handling, including gene delivery and downstream processing. Although surface engineering approaches have been studied to...

Pressure-SelectiveMagnetic Switching via SpatiallySeparated Soft Interlayer and Rigid Charge-Transfer Intralayer

Abstract We report a pressure-responsive molecule-based magnet featuring a layered cyanido-bridged Co–W assembly, [{CoII(4-phenoxypyridine)4}3{WV(CN)8}2], exhibiting a distinct pressure-selective magnetic behavior. The compound forms two-dimensional charge-transfer layers with la...

Origin of the Eleusine indica population on the active volcanic Nishinoshima Island, Japan

Nishinoshima Island, located approximately 1,000 km south of mainland Japan and 130 km from the Ogasawara Islands, emerged as a new island due to volcanic activity in 1973. On this isolated island, grasses such as Eleusine indica and Portulaca oleracea have been observed growing,...

Linear Pentanuclear 3d–4f M‐Gd‐M‐Gd‐M Complexes Prepared From a One‐Pot Reaction Show Intramolecular Ferromagnetic Interactions (M = Cu, Ni, and Co)

Three novel 3d–4f pentanuclear complexes, [Cu II 3 Gd III 2 (L) 4 (NO 3 ) 4 (H 2 O) 8 ] ( [Cu 3 Gd 2 ] ), [Ni II 3 Gd III 2 (L) 4 (NO 3 ) 4 (H 2 O) 8 ] ( [Ni 3 Gd 2 ] ), and [Co II 3 Gd III 2 (L) 4 (NO 3 ) 4 (H 2 O) 8 ] ( [Co 3 Gd 2 ] ), were synthesized via one‐pot reactions usi...

Associations of Happiness, Ikigai, and Enjoyment of Daily Life with Frequency of Forest Walking in a Japanese General Population: The Japan Multi-Institutional Collaborative Cohort Daiko Study

A number of studies have examined the acute effects of shinrin-yoku (forest bathing), or forest walking; however, only a limited number of epidemiological studies have examined the association between habitual forest walking and daily health. The aim of this study was to examine...

Decoupling Electronic Activation and Pore Connectivity in Acidic Oxygen Reduction on Metal‐Free Biomass‐Derived Carbon Catalysts

Acidic oxygen reduction is often discussed as if catalytic activation and mass transport were inseparable. Here, biomass‐derived carbon was used to examine these contributions through oxidation, ammonia annealing, and KOH activation. The onset potential is associated primarily wi...