University of Trieste

From Reactive Oxygen Species to Organelle Stress and Innate Immunity in Dry Eye Disease

Dry eye disease (DED) is a complex, multifactorial condition in which oxidative stress is increasingly recognized as a recurrent feature of ocular-surface dysfunction and as a signaling hub linking environmental stress, organelle dysfunction, innate immunity, and regulated cell d...

Early Introduction and Prolonged Full‐Dose Anakinra Reduce Recurrence Risk After Discontinuation in Recurrent Pericarditis: An International Multicenter Cohort

Background Anakinra is effective in recurrent pericarditis, yet optimal treatment duration and strategies for safe drug discontinuation remain uncertain. Identifying predictors of sustained remission after discontinuation is important for clinical management. Methods We retrospec...

When do positive leader emotions spark employee innovation? The critical catalytic role of humor in transforming affect into meaningful action

Purpose Drawing on the Conservation of Resources (COR) theory, this study examines how leader-triggered positive emotion influences employee innovative work behavior (IWB) through work meaningfulness, and whether leader humor strengthens this indirect relationship. Design/methodo...

Machine Learning the Nonradiative Decay Modes in Photochemical Processes

Abstract Nonradiative decay in photoexcited molecular systems is driven by nuclear motion toward conical intersections (CIs), where electronic states become degenerate and nonadiabatic transitions occur. Identifying the nuclear degrees of freedom responsible for CI access from no...

Use of Polycyclic Aromatic Compounds as Electrophotocatalysts in Organic Reactions

Electrophotocatalysis is the latest offshoot of two of the most innovative synthetic approaches in modern organic chemistry: on one hand, photoredox catalysis, which harnesses light to activate small molecules and construct new carbon–carbon and carbon–heteroatom bonds; and on th...

Organizational Zemblanity: How Organizational Learning Can Reinforce Rigidity, Error, and Misalignment

Organizational learning can help organizations improve and adapt, but it can also reinforce error and misalignment. These negative outcomes are often interpreted as implementation problems or as signs of incomplete learning. We instead examine the possibility that dysfunction can...

Oxygen Evolution Electrocatalysts with Trinuclear, Mixed‐Valence Iron Motifs on Electronically Aligned Carbon Dots

ABSTRACT The oxygen evolution reaction (OER), a bottleneck for water electrolysis, remains limited by the adsorbate scaling relations and sluggish interfacial electron transfer (IET). We address these challenges by anchoring mixed‐valence Fe 3+ /Fe 2+ motifs on aspartic‐acid–deri...

Community-based monitoring of neonatal jaundice using the point-of-care Bilistick® System 2.0

Neonatal jaundice often peaks after discharge, creating the need for reliable post-discharge monitoring. This study evaluated the feasibility and safety of a hospital-to-community pathway using the Bilistick® System 2.0 within routine Community Health Family Services (CHFS). This...

Joint processing of arrow direction and number magnitude strengthens Spatial-Numerical Associations: evidence from a modified flanker task

The existence of an inherent link between numbers and space is a fundamental question in numerical cognition and has been highly debated in recent years. Although Spatial-Numerical Associations (SNAs) have traditionally been investigated using bimanual response settings, recent s...

Postpandemic Trends in Pediatric Respiratory Virus Hospitalizations: A Multicenter Study, 2019–2025

ABSTRACT Background The COVID‐19 pandemic profoundly altered the circulation of respiratory viruses in children, changing the epidemiology of acute lower respiratory tract infections. In the postpandemic period, respiratory pathogens showed marked temporal variability. The 2024–2...

Phenotype-based appropriateness of IGM-enriched polyclonal immunoglobulin use in critical illness: report of an expert consensus

Sepsis and septic shock result from a dysregulated host response to infection, encompassing both hyperinflammatory and immunosuppressed phenotypes. Although immunomodulatory adjunctive therapies have been extensively investigated over the past decades, none have demonstrated cons...

The anti-GPC1 antibody AT101 as effective targeting agent for chemotherapeutic-loaded chitosan nanobubbles in the treatment of pancreatic adenocarcinoma

Recently, we developed AT101, an IgM-class mouse monoclonal antibody directed against glypican-1 (GPC1), a proteoglycan considered as useful target for pancreatic adenocarcinoma (PDAC) treatment being specifically and highly expressed on PDAC cell surface. Here, we proposed AT101...

Localized Surface Plasmon Resonance-Induced Interfacial Dynamic Charge Circulation in Plasmonic Ohmic Heterojunctions for Optimizing Hydrogen Evolution Kinetics

Abstract It remains a formidable challenge to precisely regulate interfacial charge transfer kinetics via architecting high-efficiency heterointerfaces, thereby achieving optimized hydrogen evolution reaction (HER) activity. Here, we report a strategy based on work function-media...

Evaluation of a cathelicidin derivative fusion polypeptide for pathogen-targeted antimicrobial approach

Abstract The human cathelicidin LL-37 is one of the most promising candidates for replacing standard antibiotics due to its broad-spectrum activity and low propensity for resistance development. However, the widespread clinical adoption of antimicrobial peptides (AMPs) is current...

Operando and Postmortem Study of Iridium-Decorated Titanium-Based Catalysts in PEM Water Electrolysis

Abstract Understanding the dynamic degradation of oxygen-evolution electrocatalysts under realistic operating conditions is essential for advancing the performance and efficiency of proton exchange membrane (PEM) water electrolyzers. By combining operando Small-Angle and Wide-Ang...

Antioxidant and Bioactive Properties of a Biopolymeric Matrix from Hemp Seed Waste: An Application as a Scavenger of Reactive Oxygen Species in Viscosupplements

Abstract A biopolymer-enriched matrix from hempseed waste (BMH extract) was extracted using hot water and characterized. Biochemical assays pointed out that the BMH extract contained carbohydrates, proteins, and phenols in different percentages, while NMR spectroscopy and monosac...

Value Sensitive Design for Fair Online Recruitment: A Conceptual Framework Informed by Job seekers’ Fairness Concerns

The susceptibility to biases and discrimination is a pressing issue in today’s labor markets. While digital recruitment systems play an increasingly significant role in human resource management, a systematic understanding of human-centered design principles for fair online hirin...

Valuation of GLWB variable annuities with long-term care option and accumulation phase

Abstract In the present work, we propose an evaluation framework for pricing guaranteed lifetime withdrawal benefit variable annuities equipped with long-term care (LTC) option by considering both an initial accumulation phase and a consequent income phase. Such insurance product...

Quantification of Biliverdin, Bilirubin and Bilirubin Glucuronide in Micro-Samples of Animal Blood

Circulating bile pigments are routinely measured in human and veterinary medicine, toxicology, pharmacology, and biomedical studies, as they are consolidated biomarkers of liver dysfunction and hemolysis and emerging biomarkers of biological responses to stress. This study was pe...

Cold Quantum Gravimeters: An Introduction for Geophysicists

Abstract This paper aims at providing an accessible introduction to cold quantum gravimeters tailored for geophysicists. We do not focus here on geophysical applications, as these are already well known to geophysicists, but rather provide a pedagogical exposition of the quantum-...