University of Toyama

Physiological Effects and Clinical Limitations of Impella‐Bridge Strategy for Post‐Infarction Ventricular Septal Rupture

ABSTRACT Background Post‐infarction ventricular septal rupture (VSR) remains a life‐threatening mechanical complication of acute myocardial infarction. We evaluated the feasibility of an Impella‐bridge strategy for scheduled VSR repair. Methods We retrospectively analyzed 10 cons...

Self-organized spectral adjustment in echolocation sounds within group-flying bats

Self-organized behaviour has been extensively studied in group dynamics in animals, with a strong focus on movement coordination in species like fish and birds. By contrast, far less attention has been paid to vocal interactions within animal groups. Here, we unveil a self-organi...

Structural and Mechanistic Basis of Bacterial 2-Methyl-ACC Synthases

Abstract Cyclopropane-containing amino acids are found in diverse natural products and contribute to their structural complexity and biological activity. However, the distribution of bacterial biosynthetic pathways that produce methylated cyclopropane amino acids and the structur...

Cesarean delivery and overweight at 6 years of age: a prospective cohort analysis of the Japan Environment and Children’s Study

Abstract Cesarean delivery (CD) has been suggested as a potential risk factor for childhood overweight and obesity; however, evidence beyond early childhood remains inconsistent. We examined the association between CD and childhood overweight at age 6 years and explored early lif...

Localized Surface Plasmon Resonance-Induced Interfacial Dynamic Charge Circulation in Plasmonic Ohmic Heterojunctions for Optimizing Hydrogen Evolution Kinetics

Abstract It remains a formidable challenge to precisely regulate interfacial charge transfer kinetics via architecting high-efficiency heterointerfaces, thereby achieving optimized hydrogen evolution reaction (HER) activity. Here, we report a strategy based on work function-media...

Intraoperative protamine-induced anaphylaxis suggesting the possible involvement of an immunoglobulin E-dependent pathway based on basophil activation tests: a case report

Abstract Background Protamine is a recognized cause of perioperative anaphylaxis; however, its underlying mechanism remains incompletely understood. We report a case of protamine-induced anaphylaxis, in which skin testing and basophil activation tests (BATs) suggested the possibl...

Sustained NAD⁺ augmentation by high-dose nicotinamide mononucleotide supplementation in older adults: a 24-week randomized, double-blind, placebo-controlled trial

Abstract In animal studies, the administration of nicotinamide mononucleotide (NMN), a precursor of nicotinamide adenine dinucleotide (NAD⁺), can ameliorate aging-related diseases by increasing tissue and blood NAD⁺ levels. However, human data on this intervention are limited. In...

Sequential monitoring for robot teams via temporal logic planning and persistent coverage control

This paper proposes a multi-layer control framework for monitoring environments composed of subregions under Linear Temporal Logic (LTL) specifications. Task specifications described in natural language are translated into LTL formulas for temporal logic planning. An intermediate...

Associations Between Mind Wandering and Stalking-Related Behavior: The Roles of Distress and Motivation

Abstract Stalking cases frequently involve serious risks to victims. Developing effective psychological interventions to reduce recidivism in stalking offenders requires the identification of modifiable risk factors associated with stalking-related behavior (SRB). This study expl...

Multiancestry genome-wide association and multiomics analyses elucidate spatiocellular features of multiple sclerosis genetics

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system characterized by demyelination disseminated in space and time. Here we performed a genome-wide association study (GWAS) using 688 MS cases and 205,199 controls from the Japanese population and...

Boosting the Methanol Yield of CO2 Hydrogenation by Strengthening Carbon-Mediated Hydrogen Spillover of a Copper–Zinc-Alumina Catalyst

Abstract A copper–zinc–alumina catalyst doped with activated carbon (CZA-0.1AC) is facilely fabricated via the physical mixing method. Mechanistic studies indicate that the intimate carbon–copper contact promotes hydrogen spillover, which suppresses Cu particle aggregation, stabi...

Maternal house dust–related cleaning behaviors during pregnancy and neurodevelopment from 18 months to 3 years of age in the Japan Environment and Children’s Study

To examine the association between maternal house dust–related cleaning behaviors during pregnancy and neurodevelopmental outcomes from 18 months to 3 years of age. Data from 81,125 mother–child pairs who participated in the Japan Environment and Children’s Study (JECS) were anal...

Discrete Pitch-Angle Conditions for Helicoidal Stacking of Periodically Corrugated Rods

Helical laminates, in which fibrous elements are stacked while rotating by a constant angle from one layer to the next, are common in natural and artificial materials, including Bouligand structures and fiber-reinforced composites. This study clarifies the geometric pitch-angle c...

Efficacy and safety of upadacitinib for Crohn’s disease in patients in East Asia: a post hoc analysis of randomized phase 3 studies

Abstract Background Upadacitinib is an oral Janus kinase inhibitor approved for the treatment of moderate-to-severe Crohn’s disease (CD). This post hoc analysis reports the efficacy and safety of upadacitinib for CD in patients in East Asia enrolled in the phase 3 clinical trials...

METTL18 is Required for Developmental, Metabolic, and Endocrine Regulation of Mammalian Growth

ABSTRACT Histidine methylation is an evolutionarily conserved but poorly understood post‐translational modification. METTL18 is known to catalyze histidine N τ‐methylation in vitro, yet its physiological functions in mammals remain unclear. Here we show that mouse METTL18 possess...

P1.148. Risk of Institutional Financial Deficit in Esophageal Cancer Surgery: An Analysis Focusing on DPC Margin and Length of Stay

Abstract Topic Esophageal Cancer: Other Background Esophagectomy is a highly invasive procedure requiring prolonged general anesthesia, intensive postoperative care, multidisciplinary management, and substantial healthcare resources. Under Japan’s Diagnosis Procedure Combination...

P1.035. Postoperative Acid-Suppressive Therapy Duration and Risk Factor of Gastroesophageal Reflux Disease Following Subtotal Esophagectomy

Abstract Topic Benign Disease: Iatrogenic Esophageal Disease, Perforation and Postsurgical Complications Background Gastroesophageal reflux disease (GERD) after esophagectomy is an important complication that impairs postoperative quality of life (QOL). However, factors associate...

High‐Entropy Oxides Facilitated Heterojunction Engineering With Superlattice Cd 0.6 Mn 0.4 S for Enhanced Photocatalytic Hydrogen Evolution

This study successfully constructed a highly efficient and stable photocatalytic system based on a triple synergistic catalytic mechanism involving multimetal component synergy, interfacial charge rearrangement, and Schottky barrier modulation. One‐dimensional axially oriented su...

Turbidity currents after the 2024 Noto Peninsula Earthquake and their environmental impacts on the Toyama Deep-Sea Channel in the Japan Sea

Abstract The deep-sea environment before and after the 2024 Noto Peninsula Earthquake was investigated using a series of hydrographic and mooring observations in the Toyama Deep-Sea Channel (TDSC), Toyama Bay. Transient oxygen depletion was observed after the earthquake, and low-...

Spatial control of PEG-lipid interfaces at cell surface enables on-demand adhesion and enzymatic detachment of suspension cells

Suspension cells are widely used in biomedical research and cell-based therapies; however, their lack of stable adhesion to substrates limits their efficient handling, including gene delivery and downstream processing. Although surface engineering approaches have been studied to...