Institution
University of Tokyo Hospital
Recent research
- Health & MedicineOpen access
Abstract Purpose Recurrence risk estimates underpin meningioma research, including molecular classification and clinical trial benchmarking, yet are often based on retrospective or historical data. The aim of this study was to assess the variation of recurrence risk estimates acr...
- Health & Medicine
Development and Validation of a Prediction Model for Alarm-Triggered Interventions in Pediatrics
BACKGROUND: Alarm fatigue in pediatric wards stems from frequent, nonactionable alarms that do not lead to clinical intervention. Predicting alarm-triggered clinical interventions is essential for optimizing monitoring strategies. OBJECTIVE: To identify factors associated with al...
- Health & MedicineOpen access
Abstract Background Hepatocellular carcinoma (HCC) ranks as the fifth most common cancer globally and the third leading cause of cancer-related death. Systemic therapies such as lenvatinib or the combination of atezolizumab and bevacizumab has recently emerged as a first-line the...
- Biology
De-escalation of perioperative systemic therapy for early breast cancer.
Breast cancer is the most common malignancy among women worldwide, and the number of survivors continues to increase owing to earlier detection and advances in treatment. As long-term survivorship becomes increasingly important, minimizing treatment-related toxicity without compr...
- BiologyOpen access
Screening of Xeroprotectants for Efficient MammalianCell Structural Preservation in Dry Conditions
Abstract Anhydrobiosis, the ability of organisms to survive extreme conditions such as desiccation, may represent a sustainable alternative to liquid-nitrogen (liquid nitrogen)-based cryopreservation once it can be induced in mammalian cells and germplasm. While natural xeroprote...
- Health & MedicineOpen access
AIMS: To determine the prevalence and characteristics of urinary catheter blockage in older patients using objective indicators and to characterize obstructive materials and microbiota. DESIGN: A cross-sectional study. METHODS: Patients aged ≥ 65 years with an indwelling catheter...
- Health & MedicineOpen access
Electrogram voltage reflects multiple factors, including viable myocardial mass, structural integrity, electrode configuration, catheter orientation, and activation sequence. How local myocardial wall thickness (WT) contributes to voltage amplitude in structurally intact myocardi...
- Materials & EnergyOpen access
Building a Physics-Aware AI Ecosystem for Solid-State Hydrogen Storage Materials
Abstract Hydrogen storage remains a central bottleneck for scalable hydrogen energy systems due to the multiscale and coupled nature of the thermodynamics, kinetics, and microstructural evolution of hydrogen storage materials (HSMs). Although artificial intelligence (AI) has acce...
- Materials & Energy
Abstract Crystal engineering of anisotropic molecular solids that translate photoinduced charge transfer into switchable magnetic exchange offers a route to optically addressable exchange-correlated magnetic states. Here, we show that (MV)[Co(pdms)2](MeOH)2(MeCN), a donor–accepto...
- BiologyOpen access
Subtype-specific secretion of extracellular vesicles by LRRK2 and Rab GTPases under lysosomal stress
LRRK2, the Parkinson's disease-associated kinase, phosphorylates a subset of Rab GTPases and regulates membrane dynamics. We previously reported that lysosomal stress activates LRRK2 and thereby induces the exocytic secretion of lysosomal contents, but the detailed secretion mech...
- Engineering & Technology
Abstract Reducing the interfacial contact resistance between separators and gas diffusion layers is critical for achieving high-power polymer-electrolyte membrane fuel cells. Stringent targets for contact resistance below 3.0 mΩ cm2 have been proposed; however, achieving such val...
- Materials & Energy
A ComplexSpin-Transition Thermal Hysteresis Unlockedby Two Competing Symmetry-Breakings
Abstract The spin-crossover material [Fe(NH2trz)3](NO3)2 belongs to the class of 1D triazole-based polymeric SCO complexes. It exhibits a thermal phase transition, with a 28 K wide thermal hysteresis, characterized by phase transition temperatures T↑ = 346 K upon warming and T↓ =...
- Materials & EnergyOpen access
PercolationMechanisms in Transient Polymer Networksacross Dilute and Semidilute Regimes
Abstract Percolation in transient polymer networks remains poorly understood because reversible cross-links continuously reorganize the network structure. In this study, we investigated percolation in transient polymer networks by independently controlling network connectivity an...
- Health & Medicine
Background Anti-amyloid-β (anti-Aβ) therapy slows cognitive decline but paradoxically accelerates whole-brain gray matter atrophy, complicating outcome prediction. Objective To identify early imaging markers that predict long-term prognoses. Methods This longitudinal cohort study...
- Society & EconomicsOpen access
Bone age estimation from chest radiographs using deep neural networks: a proof-of-concept study
Bone age (BA) is the gold standard for skeletal maturity assessment but is not routinely incorporated into pediatric growth evaluation workflow because it requires dedicated hand radiographs and specialist interpretation. To develop an estimation model for BA from chest radiograp...
- Health & MedicineOpen access
Abstract Bone homeostasis is maintained by coupling, in which osteoclast-mediated bone resorption is followed by osteoblast-mediated bone formation at the same site. Parathyroid hormone (PTH), including the PTH(1-34) analog, exerts distinct anabolic and catabolic effects on bone...
- Health & MedicineOpen access
Preservation of the peritoneum is essential for the safe continuation of peritoneal dialysis (PD). Although PD fluid with low glucose degradation products (low GDP) are widely used, objective macroscopic assessment of the peritoneum during ongoing PD remains limited. We therefore...