University of Tokyo Hospital

Comparative Evaluation of Prognostic Scoring Systems for Metastatic Spinal Tumors: Utility of the New Katagiri and Skeletal Oncology Research Group Models

Background: Prognostic models for metastatic spinal tumors have evolved from conventional point-based scores to models incorporating treatment, laboratory, and machine-learning variables. However, comparisons in contemporary Japanese surgical cohorts remain limited. Methods: This...

Novel noninvasive technique for liver fibrosis evaluation using spatiotemporal analysis of strain elastography

Strain elastography is often limited by its relative nature and failure to capture temporal changes. This study aimed to establish a novel quantitative strain index (Q-SI) integrating spatiotemporal analysis and evaluate its utility for assessing liver fibrosis. This prospective...

Cardiovascular complications in adults with clinically diagnosed osteogenesis imperfecta: A cross-sectional study with echocardiography and magnetic resonance imaging

Background: Osteogenesis imperfecta (OI) is a congenital bone fragility disorder, in which 90% of patients have abnormalities in type 1 collagen. Cardiovascular complications, including valvular heart disease and vascular aneurysms, are reportedly comorbid with this disease. Meth...

Evaluating a service-learning program: benefits of integrating medical students into school cancer education on teaching skills and cancer knowledge

Abstract Background Integrating medical students into school cancer education programs as service-learning is a promising strategy. This study assessed the impact of such programs and evaluated their effectiveness in improving students’ teaching self-efficacy and understanding of...

Pharmacological management of knee and hip osteoarthritis stratified by oral nonsteroidal anti-inflammatory drugs safety status

INTRODUCTION: Knee and hip osteoarthritis are treated with oral nonsteroidal anti-inflammatory drugs (NSAIDs); however, pharmacological management by NSAID safety status remains unclear. We characterized pharmacological treatment patterns across safety strata. MATERIALS AND METHO...

Dabrafenib plus trametinib in BRAF V600E-mutant Erdheim–Chester disease: a case series including CNS involvement

Abstract Background Erdheim–Chester disease (ECD) is a rare clonal non-Langerhans cell histiocytosis characterized by the infiltration of foamy, CD68-positive/CD1a-negative histiocytes into multiple organ systems. Activating MAPK/ERK pathway mutations, most commonly BRAF V600E, r...

Phase-Programmed Charge Routing Governs Kinetic and Thermodynamic Molecular Selectivity for Chemiresistive Sensors

Abstract Controlling molecular selectivity in chemiresistive gas sensors remains a fundamental challenge, particularly for chemically analogous analytes that generate indistinguishable electronic responses. Here, we demonstrate that polymorph-engineered MoS2/SnO2 heterointerfaces...

Sustained NAD⁺ augmentation by high-dose nicotinamide mononucleotide supplementation in older adults: a 24-week randomized, double-blind, placebo-controlled trial

Abstract In animal studies, the administration of nicotinamide mononucleotide (NMN), a precursor of nicotinamide adenine dinucleotide (NAD⁺), can ameliorate aging-related diseases by increasing tissue and blood NAD⁺ levels. However, human data on this intervention are limited. In...

Beyond Intrinsic Oxidation Activity: Charge-Distributed Reaction Fields in Polyoxometalate-Based Porous Ionic Crystals

Abstract Molecular catalysts assembled into solids can exhibit catalytic properties beyond those of their individual components, yet the origin of this enhancement is often unclear. Here, we address this issue using porous ionic crystals (PICs) based on polyoxometalates (POMs). T...

Neurodevelopmental Trait Subgroups in Medically Unexplained Oral Symptoms: A Retrospective Observational Study

Introduction and aims Medically unexplained oral symptoms (MUOS) are heterogeneous conditions with prominent subjective complaints despite limited objective findings. We examined whether autism spectrum disorder (ASD)- and attention-deficit/hyperactivity disorder (ADHD)-related t...

Orthodontic and surgical treatment patterns in hemifacial microsomia: a retrospective multi-institutional study in Japan

Hemifacial microsomia is a congenital craniofacial condition characterized by variable facial asymmetry and mandibular hypoplasia. Its management often requires long-term multidisciplinary care, including orthodontic and surgical treatment. However, multi-institutional data on tr...

PREOPERATIVE PAIN SENSITIVITY HAS A GREATER IMPACT ON CLINICAL OUTCOMES THAN CORONAL ALIGNMENT STRATEGY IN ROBOTIC-ASSISTED TOTAL KNEE ARTHROPLASTY: IMPLICATIONS FOR TRIAL DESIGN

Introduction Both pre-operative pain sensitivity and coronal alignment philosophy may influence patient-reported outcomes (PROMs) after total knee arthroplasty (TKA). This study investigated whether pain sensitivity predicts function in robotic-assisted TKAs 19andomized to functi...

Temporal Changes in Left Ventricular Ejection Fraction After Initiating Hemodialysis

ABSTRACT Introduction Longitudinal changes in left ventricular ejection fraction (LVEF) after commencing hemodialysis and their prognostic implications remain poorly characterized. Methods We studied 278 patients who started hemodialysis between 2010 and 2022, underwent echocardi...

Artificial dermis for protecting gastrointestinal mucosal defects: A feasibility study in ex vivo and in vivo porcine models

Although post-endoscopic submucosal dissection (ESD) mucosal defects can lead to delayed bleeding and perforation, an optimal protective method has not yet been established. This study aimed to evaluate the feasibility of using artificial dermis to protect against gastrointestina...

Development of the Japanese version of the Manchester short assessment of quality of life (MANSA) among people with self-reported severe mental illness

The Manchester Short Assessment of Quality of Life (MANSA) is a quality-of-life (QOL) instrument developed for people with mental illness. This study aimed to develop a Japanese version of the MANSA for people with severe mental illness (SMI) and examine associations between indi...

Instability-Driven Torsion Sign Flips Revealed by the Laplacian Structure of Curvature Support Fields in Protein Backbones

Abstract Torsion sign flips are fundamental discrete events in protein backbone dynamics, yet their geometric triggers remain poorly understood. While traditionally associated with singular critical points, we show that these transitions are primarily driven by local geometric in...

Serum soluble Fas levels and incidence of biliary tract cancer in a nested case-control study

Abstract Background: Soluble Fas (sFas) plays multiple roles in tumorigenesis and cancer dissemination by avoiding apoptosis via connection to Fas ligand. We assessed associations of serum sFas levels with the incidence of extrahepatic biliary tract cancer (eBTC) in a prospective...

Birth weight-stratified analysis of retinopathy of prematurity: a single-center cohort including infants below 400 g

Abstract Background This study aimed to clarify birth weight (BW)-specific ophthalmic outcomes of retinopathy of prematurity (ROP), including extremely rare survivors weighing < 400 g. Methods This retrospective single-center cohort study included preterm infants with BW < 1800 g...

Hydrothermally Grown NiFe Layered Double Hydroxide on Hastelloy Fiber Paper for the Oxygen Evolution Reaction in Anion-Exchange Membrane Water Electrolysis

Abstract Hastelloy fiber paper (HAP) exhibits excellent corrosion resistance, electrical conductivity, and structural robustness; however, its application as a porous transport layer (PTL) in water electrolysis systems remains relatively underexplored. In this study, a highly act...

Aspirin Omission at the Time of Primary Percutaneous Coronary Intervention in STEMI

BackgroundThe safety of omitting up-front treatment with aspirin during primary percutaneous coronary intervention (PCI) in patients with ST-segment elevation myocardial infarction (STEMI) remains unclear. MethodsWe conducted a multicenter, open-label, randomized trial in Japan i...