University of Tokyo Hospital

De-escalation of perioperative systemic therapy for early breast cancer.

Breast cancer is the most common malignancy among women worldwide, and the number of survivors continues to increase owing to earlier detection and advances in treatment. As long-term survivorship becomes increasingly important, minimizing treatment-related toxicity without compr...

Prevalence and Characteristics of Urinary Catheter Blockage in Patients With Long‐Term Urinary Catheterization: A Cross‐Sectional Study

AIMS: To determine the prevalence and characteristics of urinary catheter blockage in older patients using objective indicators and to characterize obstructive materials and microbiota. DESIGN: A cross-sectional study. METHODS: Patients aged ≥ 65 years with an indwelling catheter...

Screening of Xeroprotectants for Efficient MammalianCell Structural Preservation in Dry Conditions

Abstract Anhydrobiosis, the ability of organisms to survive extreme conditions such as desiccation, may represent a sustainable alternative to liquid-nitrogen (liquid nitrogen)-based cryopreservation once it can be induced in mammalian cells and germplasm. While natural xeroprote...

Revisiting low-voltage interpretation: Chamber-specific relationships between myocardial wall thickness and omnipolar voltage

Electrogram voltage reflects multiple factors, including viable myocardial mass, structural integrity, electrode configuration, catheter orientation, and activation sequence. How local myocardial wall thickness (WT) contributes to voltage amplitude in structurally intact myocardi...

Building a Physics-Aware AI Ecosystem for Solid-State Hydrogen Storage Materials

Abstract Hydrogen storage remains a central bottleneck for scalable hydrogen energy systems due to the multiscale and coupled nature of the thermodynamics, kinetics, and microstructural evolution of hydrogen storage materials (HSMs). Although artificial intelligence (AI) has acce...

Photoinduced Switching-onof Intermolecular FerromagneticExchange in a Cobalt–Viologen Donor–Acceptor Assembly

Abstract Crystal engineering of anisotropic molecular solids that translate photoinduced charge transfer into switchable magnetic exchange offers a route to optically addressable exchange-correlated magnetic states. Here, we show that (MV)[Co(pdms)2](MeOH)2(MeCN), a donor–accepto...

Low InterfacialContact Resistance between Carbon-BasedGas Diffusion Layer and Sputter-Deposited Anatase TiO2

Abstract Reducing the interfacial contact resistance between separators and gas diffusion layers is critical for achieving high-power polymer-electrolyte membrane fuel cells. Stringent targets for contact resistance below 3.0 mΩ cm2 have been proposed; however, achieving such val...

Subtype-specific secretion of extracellular vesicles by LRRK2 and Rab GTPases under lysosomal stress

LRRK2, the Parkinson's disease-associated kinase, phosphorylates a subset of Rab GTPases and regulates membrane dynamics. We previously reported that lysosomal stress activates LRRK2 and thereby induces the exocytic secretion of lysosomal contents, but the detailed secretion mech...

A ComplexSpin-Transition Thermal Hysteresis Unlockedby Two Competing Symmetry-Breakings

Abstract The spin-crossover material [Fe(NH2trz)3](NO3)2 belongs to the class of 1D triazole-based polymeric SCO complexes. It exhibits a thermal phase transition, with a 28 K wide thermal hysteresis, characterized by phase transition temperatures T↑ = 346 K upon warming and T↓ =...

Bone age estimation from chest radiographs using deep neural networks: a proof-of-concept study

Bone age (BA) is the gold standard for skeletal maturity assessment but is not routinely incorporated into pediatric growth evaluation workflow because it requires dedicated hand radiographs and specialist interpretation. To develop an estimation model for BA from chest radiograp...

PercolationMechanisms in Transient Polymer Networksacross Dilute and Semidilute Regimes

Abstract Percolation in transient polymer networks remains poorly understood because reversible cross-links continuously reorganize the network structure. In this study, we investigated percolation in transient polymer networks by independently controlling network connectivity an...

Subthreshold early white-matter hyperintensity increase predicts accelerated hippocampal and whole-brain atrophy in anti-amyloid-β immunotherapy

Background Anti-amyloid-β (anti-Aβ) therapy slows cognitive decline but paradoxically accelerates whole-brain gray matter atrophy, complicating outcome prediction. Objective To identify early imaging markers that predict long-term prognoses. Methods This longitudinal cohort study...

Parathyroid hormone exposure frequency regulates spatiotemporal coupling during bone remodeling in a functional bone model

Abstract Bone homeostasis is maintained by coupling, in which osteoclast-mediated bone resorption is followed by osteoblast-mediated bone formation at the same site. Parathyroid hormone (PTH), including the PTH(1-34) analog, exerts distinct anabolic and catabolic effects on bone...

Serial ultrafine endoscopic assessment of fibrin deposition and neomembrane formation in peritoneal dialysis patients using low glucose degradation product fluid

Preservation of the peritoneum is essential for the safe continuation of peritoneal dialysis (PD). Although PD fluid with low glucose degradation products (low GDP) are widely used, objective macroscopic assessment of the peritoneum during ongoing PD remains limited. We therefore...