University of the Basque Country

Usefulness of custom-made orthoses with 3D scanning and printing for the conservative treatment of rhizarthrosis

Background: Trapeziometacarpal osteoarthritis (rhizarthrosis) is often managed with orthopedic orthoses that are prefabricated in various sizes and may be manipulated to be adapted to the patient’s anatomy. Advances in three-dimensional scanning and printing now allow fabrication...

Influence of Zn and Cr Additions on the Microstructure and Mechanical Properties of Al–Mg–Si–Zr–Cu Multicomponent HPDC Alloys

This study develops novel multicomponent Al–Mg–Si–Zr–Cu-based alloys for high-pressure die casting (HPDC) with improved mechanical properties and thermal stability. Four compositions were designed through Zn and Cr additions, supported by thermodynamic modelling. XRD and SEM/EDS...

Environmental enrichment modulates parvalbumin interneuron deficits and plasticity-related signaling after early postnatal NMDA receptor hypofunction in male rat visual cortex

Abstract Sensory processing deficits in schizophrenia have been linked to dysfunction of cortical inhibitory interneurons, particularly parvalbumin-expressing (PV+) populations. NMDA receptor hypofunction during development is known to disrupt interneuron maturation, but its long...

Toward more accurate natural orbital functional approximations: Including 4-index cumulant contributions

Accurate modeling of bond breaking remains a central challenge for reduced density matrix functional theory (RDMFT). Although some modern functionals can yield reasonably accurate dissociation energies, they often fail to reproduce key properties of the dissociated fragments, suc...

A critical review of the early clozapine trials published in German and a discussion of the many unresolved issues left by these trials

Clozapine was (1) first introduced in Austria and Switzerland in 1972, (2) associated with 8 Finnish deaths due to agranulocytosis in 1975 (almost leading to its withdrawal), and (3) approved in the United States (US) for treatment-resistant schizophrenia in 1989 (resulting in a...

Structure-property relationships in biopolyurethane/acrylate hybrid films: Role of chain extender and acrylic content

Waterborne polyurethane/acrylic (PU/AC) hybrid dispersions are widely used in coatings applications due to their low environmental impact and tailorable thermomechanical performance, and are typically composed of particles with a core-shell morphology. Controlling phase morpholog...