University of Tennessee at Knoxville

Relaxation Polyamorphism of Rosuvastatin and Physicochemical Characterisation of a Rosuvastatin–Carvedilol Co-Amorphous System

Objective: In this study, the solid-state properties of two amorphous forms of rosuvastatin calcium (ROS) and co-amorphous systems of rosuvastatin with carvedilol (CAR) were investigated. Methods: The studied systems were investigated using TGA, DSC, TMDSC, PXRD, SAXS, SSNMR, and...

Can AI Generate Complex Passages for Reading Intervention?

Artificial intelligence (AI) increasingly is being suggested as a means to generate intervention content for students with or at risk of reading disabilities. This practice article explores the use of generative AI in creating complex passages for a nonrepetitive reading interven...

Full-covariance chemical Langevin predator–prey diffusion with absorbing boundaries

Abstract Many stochastic predator–prey models introduce independent diagonal noise at the stochastic level. Such formulations are useful phenomenological models, but they do not explicitly encode the event-level coupling created by predation and biomass conversion. We derive an a...

Fire frequency and timing influence bee–flower interactions: a case study from an oak‐pine savanna restoration on the Cumberland Plateau

Abstract Introduction Native plant communities have declined in the southeastern United States over the past century because of habitat loss and fire suppression. While restoration of these communities often requires prescribed fire, the effects of fire on endemic insects remain...

Household Poverty and Movement Behaviors in Preschool Children: A Longitudinal Study of Physical Activity, Screen Time, and Sleep

Background: Household poverty may shape physical activity (PA), screen time, and sleep during early childhood, but longitudinal evidence among preschool-aged children remains limited. This study examined longitudinal associations between household poverty status and these movemen...

Tunable Polariton Canalization in Natural Van Der Waals Oxide

ABSTRACT Hyperbolic phonon polaritons (HPPs) are coupled oscillations of anisotropic lattice vibrations and electromagnetic fields that confine the latter to the nanoscale, enabling novel nano‐polaritonic devices. While HPPs have been identified in multiple layered materials, ach...

Dual roles for a chromatin insulator-H2Av axis in the DNA damage response and hematopoietic development in Drosophila

Chromatin insulator proteins regulate genome architecture and maintain genome integrity, yet how insulator function intersects with the DNA damage response and developmental gene regulation remains poorly understood. Here we show that the Drosophila insulator protein Suppressor o...

Challenges and opportunities of generative artificial intelligence models in audio/acoustic domain: a comprehensive survey

Abstract Generative artificial intelligence (AI) has transformed image and text processing, but its adoption in the audio/acoustic domain remains underexplored due to inherent challenges in modeling long-term temporal dependencies in one-dimensional signals and achieving human-pe...

Joint-RPCA: domain-aware multi-omics integration for systems microbiology

Integrating multi-omics data is essential for microbiome research, as microbial communities are shaped by and respond to interdependent processes, including taxonomic composition, metabolite production and utilization, and gene expression. However, accurately capturing ecosystem-...

Effect of AlkaliMetal Ions and Salt Composition onStructural and Dynamical Properties of Ternary Electrolytes

Abstract Molecular dynamics simulations were employed to investigate the influence of alkali-metal ions (Li+, Na+, K+, and Cs+) and salt loading on the solvation structure, coordination environment, and transport properties of ternary electrolytes composed of a short-chain polyet...

Pair distribution analysis of short- and medium-range order of metallic glasses: Direct imaging and diffraction-based approaches

Abstract Pair distribution function (PDF) analysis provides a quantitative framework for resolving short- and medium-range order in glasses. This article summarizes recent advances that extend PDF methods from bulk x-ray and neutron-diffraction methods to local electron microscop...

CliniSense AI for automated clinical skills assessment with real-time feedback

Medical education requires scalable, reliable assessment of clinical skills, yet faculty observation cannot meet trainee volume, manual OSCE evaluation yields inter-rater reliability of only κ = 0.35–0.58 with days-to-weeks feedback latency, and no existing system provides real-t...

Obstructive shock from delayed blunt cardiac injury after chest trauma

Blunt cardiac injury (BCI) is a rare but serious presentation in emergency departments (EDs) nationwide. These injuries arise in trauma and may be accompanied by confounding injuries that complicate the clinical picture. Timely recognition is crucial, as BCI may lead to complicat...

Effect of equine flysheets on fly avoidance behaviours, body temperature, stress level, and heart rate

Abstract Background Flysheet use is common without any published scientific evidence to justify their use. Objectives To demonstrate the effectiveness of flysheets at reducing fly avoidance behaviours and measuring changes in body temperature, heart rate, and cortisol levels. Stu...

Influence of Crystal Structure, Morphology, and Microstructure on Fracture Behavior of Natural Silica Sand at Particle Scale

Abstract The strength properties of individual sand grains play a critical role in understanding the macroscopic performance of granular materials in geotechnical and material science applications. This paper investigates the tensile strength of single-crystalline and noncrystall...

Defect Landscapeand Stability of High-Entropy Carbides

Abstract High-entropy carbides (HECs) can be stabilized as single-phase solid-solution microstructures by kinetically trapping a “high-entropy state” under ambient conditions; however, such microstructures may represent metastable states rather than true thermodynamic equilibrium...

Sexual Objectification in Family of Origin, Self-Objectification, Sexual Agency, and Young Adult College Women's Orgasm

In this cross-sectional study, we examined if and how experiences of sexual objectification in one's family of origin are associated with sex-related outcomes among 700 young adult college women who completed an online survey. We found that sexual objectification in one's family...

A Cluster-POD Based Model Reduction Method for Boundary Control of Fluid Flows

Efficient reduced-order models are needed for real-time simulation and control of high-dimensional nonlinear partial differential equations (PDEs). Global Proper Orthogonal Decomposition (POD) often underperforms because it assumes a single linear subspace, which is inadequate fo...

Firearm carrying practices and motivations: A mixed methods study among adults and youth

Abstract The purpose of this participatory action, mixed methods research study was to identify motivations related to firearm carrying from a qualitative perspective, and then to use quantitative research to characterize the patterns of motivations around carrying. Qualitative i...

“I Was Determined to Take Control of My Own Body”: Self‐Managed Abortion in the US Appalachian Region

ABSTRACT Background Many people living along the Appalachian mountain region, which spread down the eastern side of the United States, experience limited access to abortion care and report high levels of distrust in health care providers. Therefore, Appalachians are likely to hav...