University of Tartu

Impact of matched samples on domain harmonization in cross-cohort NMR metabolomics

INTRODUCTION: Machine learning models trained on metabolomics data frequently show reduced performance when applied to independent cohorts because of domain shifts introduced by differences in analytical platforms, sample handling, storage conditions, and metabolite quantificatio...

Ethical regulation of human research in educational institutions for health professions: A cross-national study

Introduction: International research collaboration is increasingly valued. However, the diversity of ethical regulations for human research across health professions education institutions (HPEI) presents growing challenges. While international frameworks provide an ethical found...

An Open Data Approach for Comparing CO2 Sorbents

Abstract The rapid growth of research on CO2 capture has led to the development of hundreds of novel sorbents. Their direct comparison is challenging because the reported metrics, testing conditions, and data formats vary across studies. This study examines developments reported...

Discovery and Design of YTHDF2-Selective and Pan-YTHDF Inhibitors for m6A Binding by the YTH Aromatic Cage

Abstract Recognition of N6-methyl-adenosine (m6A) in the RNA sequences by the YT521-B homology domain-containing protein family paralogs 1–3 (YTHDF1–3) is a dominant layer of myriad cellular regulation. Dysregulated YTHDF paralog expression and activities have been reported in ca...

Nonlinear ferroelectric wires under periodic live loads: waves with period matching the forcing

Abstract We consider the dynamics of nonlinear elastic ferroelectric wires subjected to periodic external forcing. For general free energies, we determine conditions under which wave-type solutions, including the polarization field, have a period matching the one of periodic exte...

Treatment restrictions after acute stroke across nine European countries and their association with 90-day mortality: a post hoc analysis of the PRECIOUS randomised controlled trial

Background In patients with acute stroke, early withholding or withdrawal of life-sustaining therapies is associated with an increased risk of death. We used practice variation across nine European countries to assess whether this relation may be causal. Methods We performed a po...

Evaluation of Heavy Rare Earth Extraction Strategies from Fluorapatite Mineral Using D2EHPA as an Extractant

Various heavy rare-earth separation strategies for separating light rare-earth elements and calcium have been evaluated in this study. Estonian phosphorite ore (fluorapatite) was dissolved in either 2 M nitric or hydrochloric acid, and the leachate was partially saponified therea...

Against the Odds? Lessons from Establishing a Clinician Educator Career Track in a Non-Academic Medical Centre

Teaching and learning are often positioned as secondary to patient care, research, and leadership. In non-academic medical centres (NAMCs), this can make it difficult to justify investments in faculty development, as educational activities may be perceived as peripheral, even dis...

Predicting Core-Level X-ray Photoemission Spectra of Oxide Surfaces from First-Principles─A Case Study for SnO2

Abstract X-ray photoemission spectroscopy (XPS) is a powerful technique to gain insight into the chemical properties of oxide surfaces. However, the interpretation of XPS spectra is notoriously difficult as realistic surfaces contain different terminations, reconstructions, adsor...

Invisible infrastructures, visible breakdowns: Rethinking smart pedestrian crossings through maintenance and everyday use

Abstract This article examines smart pedestrian crossings as contested infrastructures within smart city initiatives. Drawing on qualitative interviews with technology developers, municipal officials, accessibility experts, and citizen focus groups, it explores how these systems...

Supporting Self-Regulated Learning in Primary Education: A Case Study in a Directed Independent Learning School

Supporting students’ self-regulated learning (SRL) in school is essential for fostering self-directed learners and depends largely on how teachers design learning environments and instructional tasks. The aim of this case study is to examine how SRL-supportive classroom practices...

Thalassinoides Ichnofabric Architecture as Complementary Evidence for Sequence‐Stratigraphic Interpretation in Carbonate Ramp Systems: Insights From the Mississippian Mobarak Formation (Alborz, Iran)

ABSTRACT This study integrates ichnological, sedimentological, and sequence‐stratigraphic observations to investigate depositional and substrate changes within the Mississippian Mobarak Formation carbonate ramp in the Alborz Basin, Iran. Four stratigraphic sections were examined,...

From printing to intelligence: Smart polymer composite actuators for next-generation soft robotics

Smart polymer composite actuators are emerging as enabling materials for next-generation soft robotics by combining mechanical compliance, multifunctionality, and programmable responsiveness within lightweight architectures. Their ability to convert electrical, thermal, magnetic,...

Child acquisition of complex consonants: The role of oral motor control in developing acoustic targets

Our study examines the role of oral motor control in the acquisition of acoustic targets for lingually complex consonants in Estonian by speakers from four age groups. We focus on children's production of secondarily palatalised and non-palatalised consonants where anatomical dev...

Holobiomes in succession: post-glacial microbial communities are structured by hosts, time and habitat heterogeneity

Abstract Glacier forefields provide model ecosystems for studying primary succession, where newly exposed substrates are colonized by microbes associated with lichens, biological soil crusts (BSCs), mosses, vascular plants, and bulk soil. Collectively, these sources form an inter...

Tuning intracellular immunity by Nodamura virus B2 protein enhances self-amplifying RNA activity

Abstract Self-amplifying RNA (saRNA) offers a powerful approach for vaccine development, as its replicative nature within cells provides prolonged antigen expression together with self-adjuvanticity. However, its potency is often limited by innate immune responses, particularly t...

Student teacher reflections on futures-oriented sustainability education: negotiating transformation in an optional course

Sustainability education (SE) calls for developing learners’ sustainability mindsets, yet less is known about how student teachers experience such learning, particularly in futures-oriented contexts. This study examines participant experiences in an optional teacher education cou...

Patterns of screen use and off-screen activities among children and adolescents and their associations with mental health

Despite the great number of studies about the association between adolescents’ screen use and mental health, the underlying mechanisms of the link are not well understood. According to the displacement hypothesis, excessive screen use may negatively affect children's development...

Combined effects of long‑term air pollution exposures on adult active asthma: a quantile g-computation analysis

Abstract Background Air pollution is a well‑established risk factor for the development of asthma, yet most studies examine pollutants individually, failing to capture the health effects of real‑world pollutant mixtures. Assessing long-term multipollutant exposure is essential fo...

Deciphering the genomic signatures of climate vulnerability across 77 sheep breeds

Abstract Among domesticated species, sheep ( Ovis aries ) have achieved a wide geographic distribution due to their mobility, rusticity and ability to adapt to diverse environments and climatic conditions. Here, we characterise the genome-wide diversity of >1,000 sheep representi...