University of Tartu

The clinical and molecular spectrum of AGO2-associated Lessel-Kreienkamp neurodevelopmental syndrome

Abstract Background Pathogenic variants in AGO2 ,encoding a central component of the RNA-induced silencing complex (RISC), cause the neurodevelopmental disorder Lessel-Kreienkamp syndrome (LESKRES). The variant spectrum and associated molecular mechanisms underlying phenotypic va...

Fitness effects of local seasonal adaptation depend on the timing of reproduction in a range-expanding butterfly

Abstract Local seasonal adaptation across latitudes is ubiquitous, but its fitness consequences are rarely estimated in the field. Using a common-garden field experiment at the northern range margin of the butterfly Lasiommata megera, we show that fitness consequences of among-po...

Contrasting population genetic structures of freshwater eels ( Anguilla marmorata, A. bicolor, A. mossambica ) from Madagascar

Abstract Freshwater eels (genus Anguilla ) are of major biological and commercial interest due to their complex catadromous life cycle and as a high‐value fishery resource, but the biology of tropical species is still poorly understood. This study investigates the genetic integri...

Misquoted No More: Securely Extracting F* Programs with IO

Shallow embeddings that use monads to represent effects are popular in proof-oriented languages because they are convenient for formal verification. Once shallowly embedded programs are verified, they are often extracted to mainstream languages like OCaml or C and linked into lar...

Appendix to "Data cooperatives starter kit: A governance artifact with fuzzy-logic stewardship evaluation"

This appendix provides the supplementary materials accompanying the paper “Data Cooperatives Starter Kit: A Governance Artifact with Fuzzy-Logic Stewardship Evaluation.”

Effect of Electrolyte,Applied Voltage, and DNA Concentrationon the Translocation Dynamics of a Single-Stranded DNA through a Solid-StateNanopore

Abstract Solid-state nanopores enable label-free detection of biomolecules by monitoring ionic current modulations during molecular translocation. However, reliable measurements are often limited by rapid, poorly controlled translocation dynamics producing short, low-resolution s...

From Noise to Knowledge: Distill Social Media Opinions on Rumor Detection Exploiting LLMs

The majority of social media research relies on datasets gathered from social media websites such as Reddit and Twitter. However, their intrinsic high noisy content reduces the performance of data-driven models. This restriction of noisy data has made data preparation techniques...

Sex-specific effects of parental age on the physiology of offspring in a long-lived seabird

Studying senescence in wild organisms reveals evolutionary trade-offs and life-history strategies that cannot be captured in laboratory settings. Long-lived seabirds from rare known-aged populations provide excellent models for examining aging under natural conditions. Because re...

Getting Around the Intrinsic Errors of Density Functional Theory Calculations in Electrocatalysis

Abstract This article shows that the intrinsic gas-phase error in density functional theory (DFT) calculations can be effectively eliminated by referencing adsorption energies and reaction barriers to surface-bound intermediates rather than to molecular species. In oxygen reducti...

Comprehensive NMR metabolomic profiling reveals a pro-atherogenic signature in psoriasis

Abstract Psoriasis (PS) is a chronic inflammatory skin disease associated with cardiometabolic comorbidity. While systemic inflammation is recognized as a major driver of this risk, metabolomic signatures linking PS to cardiometabolic dysfunction remain incompletely defined. The...

Conversational AI should fill the white space in mental health care, not replace humans

Abstract Conversational AI (CAI) is being rapidly deployed in mental healthcare, with much of the focus on chatbots delivering therapy directly to patients. However, this focus overlooks broader opportunities to improve mental healthcare as a system. Rather than replacing clinici...

Thermal activation and pozzolanic reactivity assessments of Estonian clays for cementitious applications

Abstract This study evaluates the pozzolanic reactivity of locally sourced Estonian clays as supplementary cementitious material (SCM) alternatives. Two selected clays, Arumetsa (ARC) and Aseri (ASC), were calcined in a rotary tube furnace at three distinct temperatures (750 °C,...