University of Szeged

Systematic Review of the Global Patterns and Determinants of International Student Mobility

ABSTRACT This systematic literature review synthesizes and analyses a corpus of 140 studies on the size and flows of international student mobility (ISM), as well as its determinants. The review confirms a consistent global increase in international students, albeit experienced d...

Digital Game-Based Learning in Primary Education: A Cluster-Randomized Controlled Trial on Knowledge, Skills, and Motivation

Abstract Digital technologies are increasingly integrated into primary education, yet evidence remains limited regarding how digital game-based learning (DGBL) affects the relationships among musical knowledge acquisition, aural skills development, and classroom motivation. To ad...

Measuring multidimensional student engagement beyond western contexts: A mixed-methods validation study in Mongolian higher education

Student engagement is a multidimensional construct critical for academic success in higher education, yet most measurement instruments were developed in Western contexts and lack validation for non-Western settings, particularly regarding agentic engagement. This study adapted an...

The Hidden Everyday-Life Burden of Pediatric Type 1 Diabetes: A Household Implementation Framework for Modern Diabetes Technology and Family Care

Abstract Purpose of Review Frameworks that classify the financial burdens of managing pediatric type 1 diabetes (T1D) primarily focus on measurable material hardship, affordability, and cost-related distress and therefore do not sufficiently detail the household-level resources t...

Albumin surface and interface engineering of non-albumin nanoparticles in cancer nanomedicine: A critical review

Engineered albumin interfaces can modify the biological identity and performance of non-albumin nanoparticles in cancer nanomedicine, but their independent contribution is often obscured by multicomponent designs. This critical review evaluates studies in which albumin or an albu...

Longitudinal evidence for decreasing statistical learning abilities across childhood

Abstract Statistical learning enables us to identify patterns in our environment and predict future events, thereby supporting a range of motor, cognitive, and linguistic skills. Despite its significance, the developmental trajectory of statistical learning has remained unclear d...

Guidance for laboratory implementation, governance and continuous assurance of artificial intelligence in histopathology

Abstract Artificial intelligence (AI) is rapidly transforming histopathology, with applications ranging from workflow optimisation and quality assurance to tumour diagnosis, grading, biomarker assessment and estimation of prognosis. While numerous AI algorithms have demonstrated...

Oral health and systemic health outcomes: A call for interdisciplinary action

Abstract Objectives To make the case, from periodontology and dental public health, for interdisciplinary action on oral and systemic health, and to set out recommendations for practice, policy, education, and research. Materials and Methods A joint working group of the European...

Effect of Aficamten on Cardiac Structure and Function in Patients with Symptomatic Nonobstructive Hypertrophic Cardiomyopathy

BACKGROUND: Aficamten significantly improved both functional capacity and patient-reported health status in patients with symptomatic nonobstructive hypertrophic cardiomyopathy in the phase 3 randomized, placebo-controlled ACACIA-HCM trial (Assessment Comparing Aficamten to Place...

From financial cutbacks to ethical trade-offs: exploring the influence of welfare and consumer values on ethical consumption during economic crisis

Purpose This study investigates how perceived economic conditions, materialism and frugality influence ethical purchasing behavior during economic crises triggered by the COVID-19 pandemic and the war in Ukraine. Specifically, we examine whether negative perceptions of past econo...

Global Efficacy of Aficamten in Nonobstructive Hypertrophic Cardiomyopathy: Results From ACACIA-HCM

BACKGROUND: Nonobstructive hypertrophic cardiomyopathy (nHCM) is associated with significant morbidity with no approved treatment. Aficamten is a cardiac myosin inhibitor targeting excess contractility and diastolic impairment, the predominant mechanism responsible for adverse ou...

flexiAsCas12a and other Cas12a variants enhance the applicability of Cas12a nucleases in prime editing

Abstract Background Amongst the genome manipulation tools based on the versatile CRISPR-Cas system, prime editing is the most prominent one as a method that enables precise insertions, deletions, and substitutions without inducing double-strand breaks. Cas12a nucleases are widely...

Aficamten for Symptomatic Nonobstructive Hypertrophic Cardiomyopathy

BACKGROUND: Nonobstructive hypertrophic cardiomyopathy (HCM) is a common condition that is associated with substantial morbidity and no proven medical therapy. Whether treatment with aficamten, a cardiac myosin inhibitor, can benefit patients with this condition is unknown. METHO...

Controlling pH-Dependent Nanozyme Activity by Metal Identity in Histidine-Based Nanoarchitectures

In this paper, we report a metal-driven structural tuning strategy with the L-histidine (His) ligand to modulate peroxidase-like nanozyme performance. Although the His coordinates with gold(III) ions to form an extended helical coordination polymer, its interaction with Cu(II) io...

Toward AI-Driven Detection of Asymptomatic Chronic Conditions from Stool Metagenomics and Dietary Data: A Multimodal Deep Learning Framework for T1DM, T2DM, MOS/PCOS, Cancer, and Autoimmune Disease

Chronic non-communicable conditions—type 1 and type 2 diabetes mellitus (T1DM, T2DM), metabolic obesity syndrome (MOS), polycystic ovary syndrome (PCOS), colorectal and extra-intestinal cancers, and systemic autoimmune disease—share a prolonged asymptomatic phase during which con...

P1.019. Benign Oesophageal Tumors Removals by Laparoscopic Transhiatal and Thoracoscopic Way

Abstract Topic Benign Disease: Esophageal Surgery Background Benign oesophageal tumors are rare conditions and account for about 18-20% of oesophageal neoplasms on autopsy. During the past decade the laparoscopic and robotic assisted transhiatal and thoracoscopic transthoracic ap...

Bacteriophage Challenge Drives Genomic and Proteomic Remodeling and Alters Antibiotic Resistance in a Methicillin-Resistant Staphylococcus aureus

Background/Objectives: Methicillin-resistant Staphylococcus aureus (MRSA) is a major therapeutic challenge due to its extensive antibiotic resistance. This study examined how bacteriophage exposure affects the genome, proteome and antibiotic susceptibility of a clinical MRSA isol...

European S2k guidelines for hidradenitis suppurativa/acne inversa Part 1. Epidemiology, diagnosis and clinical assessment

BACKGROUND: This first part of the S2k guidelines is an update of the 2015 S1 European guidelines based on the structured assessment of clinically relevant topics by the panel of experts. It is complemented by Part 2, which deals with treatments. OBJECTIVES: These guidelines aim...

On the pathway of changing emotions—a qualitative study of emotional changes in breast cancer patients from the first detection of the tumor to breast surgery

Abstract Background The trajectory of breast cancer is a dynamic experience, both physically and emotionally, and despite the same diagnosis, the emotional reactions to events during the healing process are quite individual. Therefore, to support the coping processes with the dis...

Interaction Between Cereals and Pea Intercrops During Their Initial Development

The species that make up the intercrop interact with each other during their development, which can be beneficial, harmful, or indifferent to the participants. The aim of this study was to determine whether the developmental differences observed between intercropped and pure stan...