University of Sussex

A proteomic analysis of the PHF-forming tau fragment (tau297-391) following uptake into differentiated human neuronal SHSY5Y cells

Tau self-assembly and intracellular deposition is associated with a group of neurodegenerative diseases called tauopathies, which include Alzheimer's disease (AD) and Pick's disease. Here, we measured the proteome response in human neuronal cells (differentiated SH-SY5Y) followin...

Hyperactivity in context: comparing actigraphy and informant ratings across the school week

Background Hyperactivity is a core symptom of childhood attention deficit hyperactivity disorder (ADHD), yet no population‐based studies have compared objective and subjective hyperactivity measures across the school day. Methods This study used data from N = 6,518 seven‐year‐old...

Does cross-border regulatory cooperation reduce excessive risk-taking?

This study investigates how heightened regulatory scrutiny by the U.S. Securities and Exchange Commission (SEC), caused by the passage of the Multilateral Memorandum of Understanding (MMoU), affects excessive risk-taking by U.S. listed foreign firms. Using data from 37 countries...

Regularity for monotone operators and applications to homogenization of p-Laplace type equations

In this manuscript, we provide local $L^q$-estimates for the gradient of solutions of a class of quasilinear equations whose principal part lacks strong monotonicity. These estimates are used to establish uniform large-scale $L^q$-estimates for the gradient of solutions of degene...

Future agendas for disability focused arts and humanities research

The arts and humanities have historically made a significant contribution to disability studies. This paper seeks to build on this history by exploring what researchers from these disciplines consider to be priority future research agendas. Following a review of the relevant forw...

Ablation removal of transport-blocking defects in surface-electrode ion traps

We demonstrate in situ removal of a transport-blocking defect on a surface-electrode ion trap device using a Q-switched Nd:YAG 532 nm pulsed ablation laser. This approach eliminates the need to vent and rebake the vacuum system, providing a low-overhead defect-remediation techniq...

Managing the product lifecycle of non-fungible tokens: A micro-level perspective

Abstract Non-Fungible Tokens (NFTs) have become part of the product portfolios of many brands, ranging from individual creators to established firms. Yet, we currently have a limited understanding of how NFTs should be designed, launched, and managed effectively over their lifecy...

Review of Particle Physics *

The Review summarizes much of particle physics and cosmology. Using data from previous editions, plus 3,200 new measurements from 903 papers, we list, evaluate, and average measured properties of gauge bosons and the recently discovered Higgs boson, leptons, quarks, mesons, and b...

The Search for Life Elsewhere: Avoiding Hype and Fostering Public Understanding

The search for life beyond Earth presents unique challenges for science communication due to its interdisciplinary nature, the potential for groundbreaking discoveries, and the inherent uncertainties involved. The Lorentz Center workshop Breaking News: We Found Extraterrestrial L...

Bittersweet: a multi-method qualitative analysis of Sugar-Sweetened Beverages (SSB) tax discussion in the Nigerian media

Abstract In 2021, the government of late President Muhammad Buhari signed the Finance Act of 2021 into law. This law, through the Customs, Excise, Tariffs, etc. (Consolidation) Act, instituted a ₦10-per-litre tax on Sugar-Sweetened Beverages to reduce excessive added-sugar consum...