University of South Florida

The Impact of Isoniazid Preventive Therapy on Tuberculosis Infection and Disease Progression.

BACKGROUND: Tuberculosis (TB) causes major morbidity and mortality among children worldwide. Isoniazid preventive therapy (IPT) protects against progression to TB disease, but its effect on preventing new TB infection remains uncertain. METHODS: We conducted a longitudinal cohort...

Enhancement of cytokine-mediated beta-cell apoptosis by free fatty acids

Type 1 diabetes (T1D) results from dysfunction and loss of the insulin-producing pancreatic β cells. The body’s lipid metabolism is strongly regulated during this process but there is a need to understand how this regulation contributes to the β-cell death. Here, we investigated...

Synthesis of the A/B ring system of withaferin A-type withanolides

Withanolides are C28 steroidal lactone plant-based natural products with diverse pharmacological activities, yet their synthesis remains challenging owing to the highly oxidized A/B ring system. Herein, we report a concise, protecting group-free route to the 1‑oxo‑2‑ene‑4β‑hydrox...

Content analysis of undefined arbitrary unit labels in scientific figures

Purpose: In scientific notation, “a.u.” denotes atomic units, but in figure labels it is also widely used to mean arbitrary units. This technically incompatible dual usage motivated this study, which examined the prevalence, disciplinary distribution, and editorial handling of th...

Controversies in the management of fetal growth restriction: a state-of-the-art review

Fetal growth restriction (FGR) affects 5%-10% of pregnancies and remains a major contributor to stillbirth, neonatal morbidity, and long-term adverse outcomes. Despite its clinical importance, substantial controversy persists regarding its definition, diagnostic criteria, surveil...

Chiari I Malformation in Pregnancy: A Retrospective Review of Maternal Outcomes and Anesthetic Safety, and a Survey of Current Practices

Abstract We sought to evaluate outcomes of pregnant patients with Chiari malformation (CM). We evaluated the relationships between mode of anesthesia and delivery with neurologic outcome in these patients. We conducted a single-center, retrospective review of pregnant patients wi...

USF x HTB Writeups for "Jinja journal" and "Dancing Files"

These writeups are for the USF x HTB CTF completed in Spring 2025. These are being published for anyone looking to walktrhough the machines after the fact and to shine light on my own technical ability. Despite this being a team competion, neither of my teamates were able to comp...

Robust Inference With Ghostknockoffs in Genome‐Wide Association Studies With Sample Relatedness

ABSTRACT Genome‐wide association studies (GWASs) have been extensively adopted to depict the underlying genetic architecture of complex traits. Recent studies show that knockoff‐based methods can identify variants with unique, potentially causal effects on phenotypes. However, th...

Addressing Medical Neglect in Children With Complex Chronic Conditions

In this issue of Pediatrics, Cleveland et al report a cross-sectional analysis of a 2-state, multiyear database of linked child protective services (CPS) and Medicaid claims data to characterize the prevalence and associations of complex chronic condition (CCC) status across CPS...

Aflibercept 8 mg in neovascular age-related macular degeneration and diabetic macular oedema: Translating clinical trials into clinical practice

Abstract Provide expert-informed guidance on the integration of aflibercept 8 mg into routine clinical care for patients with neovascular age-related macular degeneration (nAMD) and diabetic macular oedema (DMO), based on clinical trial and real-world evidence. Sixteen retina spe...

Body Composition Assessment in Pediatric Cystic Fibrosis in the Highly Effective Modulator Therapy Era—A Pilot Study

Background/Objectives: The prevalence of obesity in cystic fibrosis (CF) has increased following the introduction of highly effective modulator therapy (HEMT). However, the impact of increased adiposity on the lung function of pediatric patients with CF (ppwCF) in the era of HEMT...

Glomerulus-Targeted Nanotherapy via Collagen IV-α3 Binding Enhances Renal Immunoregulation in Lupus Nephritis

Lupus nephritis requires long-term immunosuppressive therapy, which is often associated with severe systemic side effects. Therefore, new therapeutic strategies that maintain high efficacy while minimizing adverse effects is essential. Although nanomedicine has advanced systemic...

Skeletal muscle H3K18 lactylation inhibits hepatic gluconeogenesis through IL-6 mediated interorgan communication

The mechanisms underlying the dynamic interplay between skeletal muscle and systemic glucose homeostasis in type 2 diabetes remain elusive. Increased lactate level has long been noticed in diabetes, however, whether the elevated lactate is a cause or consequence of impaired gluco...

Density dependence and evolvability limit adaptive therapy in non-small cell lung cancer mouse model

Abstract Using NSG mice grafted with H3122 non-small cell lung cancer cells, we compared outcomes from (1) continuous therapy with alectinib, (2) adaptive therapy where alectinib was cycled on and off based on a mouse’s tumor burden, and (3) no treatment. Adaptive therapy has pro...

Partial Reproducibility and Pleiotropic Epigenetic QTLs in Arabidopsis Recombinant Inbred Lines

Unlike conventional genetic polymorphisms, many induced epigenetic polymorphisms can be reset across generations, raising uncertainty about how consistently the same epigenetic loci and associated phenotypic effects can be recovered among independent studies. To address this prob...

From Choose and Hope to Evidence and Impact: Rethinking School-Based Behavioral Health Decisions

A challenge in school-based behavioral health is how evidence-based practices are selected and implemented. Decision-making within schools often prioritizes feasibility instead of research evidence. The purpose of this study was to examine the experiences of school decision-maker...

Sleep MAPP: a decision support tool for guideline-concordant sleep care in the polytrauma/traumatic brain injury system of care

OBJECTIVE: First, to summarize the development of Sleep MAPP, a decision support tool designed to facilitate guideline-concordant sleep disorder care in the Veterans Health Administration (VHA) Polytrauma/Traumatic Brain Injury System of Care (PSC). Second, to assess usability, a...

Point-of-Care Ultrasonography by Advanced Practice Providers for Patients With Undifferentiated Shock

BACKGROUND: In this evidence-based practice project, point-of-care ultrasonography by advanced practice providers was implemented in a central Florida intensive care unit. The project was guided by the following question: Does implementation of point-of-care ultrasonography by cr...