University of South China

Disrupting TERT-USP7 interaction to induces telomere-dependent senescence in hepatocellular carcinoma via mannose metabolism modulation

Abstract Induction of cellular senescence is an emerging therapeutic strategy for hepatocellular carcinoma (HCC) that exhibits inherent limited responsiveness to targeted therapies. However, the existing therapeutic methodologies for senescence induction predominantly depend on n...

Efficient Removal of Cesium Ions from Radioactive Wastewater Using Na+-Intercalated Layered Manganese Oxide via Solid-Phase Synthesis

Abstract Efficient capture of radioactive cesium is critical for the long-term development and environmental protection of nuclear energy. This article reports the preparation of Na+-based cation-intercalated manganese oxide (CIMO) via a solid-phase reaction method and their appl...

Ovarian tumor domain-containing protein 1 deficiency attenuates metabolic dysfunction-associated steatotic liver disease by promoting the ubiquitination of HSP90α in hepatocytes

Abstract Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent chronic liver disease worldwide, yet approved pharmacotherapies remain limited. The ovarian tumor domain-containing protein 1 (OTUD1) has been implicated in metabolic regulation, but i...

Systematic benchmarking of evaluation paradigms, safety boundaries, and clinical reasoning gaps for multimodal large language models in rehabilitation

Abstract Motor rehabilitation and clinical biomechanical assessment rely on expert judgement to evaluate movement quality, pathological compensation, and spatiotemporal motor dynamics. Existing automated approaches mainly depend on conventional computer vision methods, such as sk...

The association between Oxidative Balance Score and anemia in adults

Oxidative stress is implicated in the pathogenesis of anemia. The Oxidative Balance Score (OBS), a comprehensive metric assessing the combined impact of dietary and lifestyle factors on oxidative stress, has not yet been investigated in relation to anemia prevalence. We conducted...

Lattice-data-driven specific heat and isentropic bulk modulus of SU(3) gluon matter at finite temperature

Abstract We investigate the specific heat and isentropic bulk modulus of finite-temperature pure SU(3) gauge matter within a lattice-data-driven phenomenological framework. The equation of state is formulated in terms of a temperature-dependent effective gluon mass constrained by...

Cardiac fibrosis: mechanistic insights and translational advances

Abstract Cardiac fibrosis is a critical pathological process driving the progression of heart failure, characterized by excessive extracellular matrix deposition, collagen network remodeling, and expansion of the myocardial interstitium. While fibrosis may reflect a reparative re...

HierHGT-DTI: a multiscale relation-aware heterogeneous graph transformer for cold-start drug-target interaction prediction

Cold-start drug–target interaction (DTI) prediction requires transferring structural and sequence evidence to drugs or proteins with no interaction labels in the training set. This challenge is especially relevant for newly implicated or poorly characterized protein targets that...

Ultra-sensitive 2D Dion−Jacobson perovskite phototransistors for optoelectronic neuromorphic computing

Metal halide perovskite semiconductors demonstrate significant advantages over traditional semiconductor materials in next-generation weak-light-responsive devices, owing to their exceptional photoelectric conversion capabilities and outstanding charge transport properties. Under...

Unveiling the Diagnostic Value and Potential Therapeutic Targets of Phenylalanine Metabolism in Pancreatic Cancer via Integrated Multi‐Omics and Machine Learning

ABSTRACT Pancreatic cancer (PC) presents a significant global health challenge because of its high mortality rate, highlighting the urgent requirement for effective early diagnostic and therapeutic strategies. This study examined the function of phenylalanine metabolism in PC and...

Strong Hydrogen Bond Interaction Induced Dimensional Evolution in Aromatic Diammonium-Based Perovskite/Perovskitoid for Achieving High-Performance X-ray Detection

Abstract 2D perovskite single crystals (SCs) based on various aromatic diammonium cations have demonstrated significant potential in high-performance X-ray detection. Nevertheless, the relationship between the structure of aromatic diammonium cations and perovskite dimension rema...

Regulating d-band center and d-p orbital alignment to enhance K 2 NiF 4 -type cathode performance for protonic ceramic fuel cells

Abstract Regulating the transition-metal d-band center and metal-oxygen orbital alignment represents a potentially useful approach to improve cathodic oxygen reduction reaction (ORR) kinetics in protonic ceramic fuel cells (PCFCs). Herein, K2NiF4-type La0.5Sr1.5MnO4+δ (LSMO) and...

Integrated multi-omics analysis identifies AKR1B15 and SLC4A10 as prognostic candidate citrullination-related genes associated with metabolic and immune programs in hepatocellular carcinoma

Protein citrullination has been increasingly implicated in tumor progression and immune regulation, but the prognostic and cellular characteristics of citrullination-related genes (CRGs) in hepatocellular carcinoma (HCC) remain incompletely understood. We integrated bulk transcri...

Outcomes of the modified Woodward procedure with and without concomitant clavicular osteotomy and intraoperative neurophysiological monitoring for Sprengel deformity: a retrospective cohort study with a minimum 2-year follow-up

Surgical treatment of Sprengel deformity aims to improve shoulder symmetry and active shoulder motion while avoiding neurovascular injury. Whether clavicular osteotomy should be added to the modified Woodward procedure remains controversial, particularly because intraoperative ne...

Integrated analysis of single-cell and transcriptome data reveals temporal dynamics of microglial phagocytic reprogramming in neuropathic pain progression

Abstract Neuropathic pain (NP) often progresses from acute to chronic, but the mechanisms driving this transition remain unclear. Microglia play a central role in spinal sensitization, yet their functional evolution during pain chronification is poorly understood. Through integra...

Durability of CO 2 mineralized materials and products

This review provides an overview of the durability performance of CO2 mineralized cementitious materials. Most recent research emphasized the importance of post-hydration following carbonation to ensure better durability performance. Mineral carbonation generally reduces chloride...

Copper binding heterogeneity of pH-fractionated soil dissolved organic matter (DOM) revealed by multi-spectroscopy and two-dimensional correlation analysis

Soil dissolved organic matter (DOM) plays a pivotal role in governing the environmental behavior and fate of metal ions. The inherent heterogeneity of DOM, however, leads to complex and poorly understood interactions with heavy metals. In this study, soil DOM was fractionated int...

Regulating H‐Aggregation via a Thiazole‐Modified Acceptor‐Based Packing Reshaper Toward Highly Efficient and Stable Organic Solar Cells

ABSTRACT Organic solar cells (OSCs) based on non‐fullerene acceptors have achieved power conversion efficiencies (PCEs) exceeding 20%. However, their long‐term stability remains limited by uncontrolled molecular aggregation and morphological degradation in bulk heterojunction (BH...

Ordered J‐Aggregation Directed by Inner Alkyl Chains Enables Additive‐ and Annealing‐Free Organic Solar Cells With 20.73% Efficiency

ABSTRACT Molecular aggregation behavior of non‐fullerene acceptors (NFAs) plays a pivotal role in the photovoltaic performance of organic solar cells (OSCs). In Y‐series NFAs, excessive H‐like core contacts may increase packing disorder, while terminal group‐mediated J‐like inter...

Photocatalytic Four-Component Sulfonylation/ Ipso -Spirocyclization of N -Arylpropiolamides with Thianthrenium Salts, DABSO and H2O: Access to 3-Sulfonyl-Azaspiro[4.5]trienones

Abstract A visible-light-induced sodium fluorescein-catalyzed four-component cascade reaction of N-arylpropiolamides, aryl thianthrenium salts, DABSO, and H2O has been developed, providing efficient access to diverse 3-sulfonyl-azaspiro[4.5]trienones in moderate to good yields. T...