University of South China

Multimodal fusion of radiomics, dosiomics and deep learning for predicting radiation-induced hypothyroidism after radiotherapy in nasopharyngeal carcinoma: a multicenter study

To develop and externally validate a prediction framework integrating clinical factors, dose‒volume histogram (DVH) parameters, radiomics, dosiomics and deep - learning (DL) features for individualised radiation-induced hypothyroidism (RIHT) risk assessment. This retrospective mu...

Neuroprotection in the early window: a randomized controlled trial of butylphthalide initiation within 3 hours in acute ischemic stroke

Neuroprotective agents have shown promise in preclinical studies but failed to demonstrate efficacy in clinical trials, potentially due to delayed treatment initiation. The optimal therapeutic window for neuroprotection in acute ischemic stroke (AIS) remains undefined. We aimed t...

Solid–LiquidDual-Signal Spatial Isolationin High-Spin Iron/Triethanolamine Comodified Silica for Cross-Interference-FreeOne-Pot Sensing of Chlortetracycline and d -Penicillamine

Abstract Co-occurrence of antibiotics and related metabolites in food chains aggravates toxic effects and the risk of drug resistance, highly requiring the development of an efficient yet convenient approach to achieve their synchronous detection in mixed systems. To meet this de...

Geriatric nutritional risk index and prognosis in middle-aged and elderly patients with nasopharyngeal carcinoma

To evaluate the prognostic value of the pretreatment Geriatric Nutritional Risk Index (GNRI) in middle-aged and older patients with nasopharyngeal carcinoma (NPC). This study included 235 patients with NPC aged ≥ 50 years. Patients were stratified into low GNRI (GNRI ≤ 98) and hi...

Spectral-habitat analysis and perfusion fingerprinting on contrast-enhanced ultrasound for characterizing tumor perfusion in breast lesions

To develop a short-time Fourier transform (STFT)-based perfusion fingerprinting method combined with spectral-habitat analysis for characterizing pixel-wise perfusion heterogeneity on contrast-enhanced ultrasound (CEUS) and to evaluate its ability to differentiate benign and mali...

Enzymatic Ligation-Enhanced Catalytic Hairpin Assemblyfor Accelerated Kinetics with Restricted Leakage

Abstract Enthalpy-driven catalytic hairpin assembly (CHA) suffers from an inherent trade-off, wherein enhanced reaction kinetics is inevitably accompanied by elevated nonspecific background. Catalytic hairpin assembly-and-cyclization (CHAC) integrates CHA with enzymatic ligation,...

Wearable Electronics for Precision Diagnosis Through Advanced Manufacturing and Integration

Wearable electronics are rapidly transforming healthcare by enabling continuous, real-time monitoring of physiological and molecular signals directly at the point of need. This shift supports a transition from episodic, generalized care toward precision diagnosis, where individua...

A retrospective study on clinical and survival differences of head and neck versus other second primary malignancies in nasopharyngeal carcinoma survivors

Abstract Background Nasopharyngeal carcinoma (NPC) survivors face elevated risks of second primary malignancies (SPM); however, disparities between head and neck (HN-SPM) and non-head and neck (non-HN-SPM) are incompletely characterized. Methods This retrospective study analyzed...

Real-world evidence of immunotherapy in older adults with advanced non-small cell lung cancer: a retrospective cohort study

Older patients are underrepresented in clinical trials of immunotherapy for driver gene-negative advanced non-small cell lung cancer (NSCLC). This study aimed to investigate real-world efficacy and safety of immunotherapy in this population. Clinical data from 649 patients aged ≥...

The Impact Mechanisms and Paths of the National Big Data Comprehensive Pilot Zones on Urban Pollution Reduction and Carbon Mitigation

The National Big Data Comprehensive Pilot Zone (NBDCPZ) constitutes a landmark institutional initiative designed to advance and deploy data elements while strengthening governance capacity for environmental sustainability and low-carbon transition. Drawing on a panel dataset cove...

OTOF Promotes Clear Cell Renal Cell Carcinoma Progression and Angiogenesis Through AKT-Dependent HIF/VEGFA Signaling

Background: Clear cell renal cell carcinoma (ccRCC) is characterized by marked molecular heterogeneity, aggressive clinical behavior, and prominent angiogenesis, highlighting the need to better understand the functional regulators underlying tumor progression and vascular remodel...

Establishing the role of ZBTB20 mutations in GnRH deficiency and impaired neurogenesis in the subventricular zone: a human cohort and animal model study

Background Congenital hypogonadotropic hypogonadism (CHH) arises from defective development or dysfunction of GnRH neurons. Olfactory bulb (OB) malformations frequently accompany CHH, a condition termed Kallmann syndrome (KS). Nevertheless, approximately 50% of CHH cases remain g...

A graph neural network-based model for analyzing social relationships and predicting service needs among the elderly

As the population ages, there will be a significant increase in the need for intelligent systems that can comprehend individuals’ social interactions and anticipate the services they want. It is impossible for traditional methods of determining what older people need, based on st...

The TLR9-CXCL2 complex orchestrates mitochondrial DNA-driven regulatory B cell dysfunction in acute lung injury

Acute lung injury (ALI)/Acute respiratory distress syndrome (ARDS) is a lethal condition driven by unresolved inflammation. Circulating mitochondrial DNA (mtDNA) acts as a potent damage-associated molecular pattern, yet its direct role in disrupting adaptive immune checkpoints re...