University of Siena

Flexible Late Mousterian lithic technological organisation at Riparo l’Oscurusciuto (Italy): A typo-technological and 3D-based approach

Abstract The portion of the Riparo l’Oscurusciuto (Italy) stratigraphic sequence so far excavated provides an outstanding record of the local population history between ca. 55 − 42 kya BP: a key period for understanding the end of the Middle Palaeolithic and the onset of the Uppe...

Effects of Botulinum Toxin Injection on Masticatory Muscle Activity in Sleep Bruxism: A Systematic Review and Meta-Analysis

Background/Objectives: Bruxism, encompassing both awake (AB) and sleep bruxism (SB), is a prevalent condition associated with involuntary jaw muscle activity, leading to tooth wear and muscle hypertrophy. Botulinum toxin type A (BoNT-A) has emerged as a potential treatment by red...

Management of Acute Periodontal Conditions—The EFP S2k Level Clinical Practice Guideline

BACKGROUND: The European Federation of Periodontology (EFP) has developed Clinical Practice Guidelines (CPGs) for the treatment of periodontitis and for the management of peri-implant diseases. In accordance with the 2018 Classification, acute periodontal conditions are character...

Monoterpenes as biostimulants: dose-dependent effects on metabolic and nutritional traits of lettuce ( Lactuca sativa L.)

Plant-derived substances, particularly monoterpenes, offer eco-friendly biostimulant potential to enhance crop yield and nutritional quality, yet their individual effects remain poorly explored. This study investigated the physiological and metabolic responses of lettuce (Lactuca...

Smartphone-Based Automated Quantification of Bulbar Conjunctival Hyperemia Using Vessel Density Mapping

Purpose: To develop a smartphone application (Conjunctiva VD) that objectively quantifies bulbar conjunctival hyperemia by estimating the conjunctival vessel density (VD) within a user-defined region of interest (ROI). Methods: A total of 100 conjunctival images from 2 public dat...

Predicting the risk of dehydration and readmission among rectal cancer patients with ileostomy: a multicenter observational study

Abstract Dehydration is a frequent complication among rectal cancer patients after ileostomy, often resulting in hospital readmission. The Dehydration Readmission after Ileostomy Prediction (DRIP) score was used to identify patients at risk of dehydration-related readmission. The...

C–C cross-couplings via plant-derived biosurfactant micellar catalysis: A path toward reduced process toxicity

The use of sustainable, low-toxicity reaction media remains a major challenge in modern organic synthesis. In this paper, we report the use of Plantacare 2000 (PL-2000), a fully biodegradable biosurfactant derived from renewable plant sources, as a micellar reaction medium for pa...

Association Between Proton Pump Inhibitor Use and Gastric Neuroendocrine Neoplasms in Autoimmune Gastritis: A Real‐World Propensity Score‐Matched Study From the Autoimmune gastRitis Italian netwOrk Study grOup

ABSTRACT Background and Aims Autoimmune gastritis (AIG) is characterized by chronic hypergastrinemia and is associated with an increased risk of gastric neuroendocrine neoplasms (gNENs). Because proton pump inhibitors (PPIs) further increase gastrin secretion, concerns have been...

Covalent Targeting and Thermostabilization of Oncogenic R280K and R273H Mutants p53 by Small Molecule RVJB59

Breast cancer is one of the most common cancers worldwide. Approximately 30%–40% of breast cancers harbor mutations in the TP53 gene, leading to structural and functional alterations in the p53 protein. These changes result in mutant proteins that are unable to perform their cano...

Combined Botulinum Toxin Type A and Hyaluronic Acid Versus Exclusive Hyaluronic Acid Injections: A Potential Nonsurgical Alternative for Chin Augmentation

Nonsurgical chin augmentation with hyaluronic acid (HA) fillers is a widely used technique in aesthetic medicine. However, outcomes may be influenced by hyperactivity of the mentalis muscle, which may lead to reduced longevity. Botulinum toxin type A (BoNT-A) may improve filler i...

Functional Brain Network Alterations Linked to Cancer-Related Cognitive Impairment in Breast Cancer Patients

Abstract Background Life expectancy for cancer patients has improved due to new therapies, but many survivors experience long-lasting side effects, including cancer-related cognitive impairment (CRCI). CRCI symptoms—such as difficulties with attention, memory, processing speed, f...

Efficacy of dolutegravir or bictegravir-containing therapy in a real-life cohort of people with HIV-1 sub-subtype A6

OBJECTIVE: The objective of the study was to establish whether HIV-1 sub-subtype A6 (HIV-1A6) is a risk factor for virological failure in people with HIV (PWH) treated with the high genetic barrier integrase strand transfer inhibitors (INSTIs) dolutegravir (DTG) or bictegravir (B...

Effects of multi-scale drivers on plant diversity and forage quality in traditional wood-pastures of Transylvania (Romania)

Traditional wood-pastures are agroforestry systems shaped by long-term low-intensity management. However, the relative importance of drivers of plant diversity and forage quality operating at different spatial scales in these systems remains poorly understood. We investigated 30...

Autochthonous chikungunya virus outbreak in Verona province, Italy, 2025

Abstract Background Chikungunya virus (CHIKV), primarily transmitted by Aedes mosquitoes, has increasingly caused autochthonous outbreaks in temperate regions, including Italy. In 2025, a local CHIKV outbreak occurred in Verona province, Veneto Region. We report the findings of i...

Firms' Payoffs in a Bertrand‐Edgeworth Game Under Triopoly

ABSTRACT This paper studies Bertrand‐Edgeworth competition among firms producing a homogeneous commodity under efficient rationing and constant (and identical across firms) marginal cost until full capacity utilization is reached. The focus is on the equilibrium payoffs under tri...

CIRO7.2: A Material Network with Circularity of -7.2 and Reinforcement-Learning-Controlled Robotic Disassembler

The competition over natural reserves of minerals is expected to increase in part because of the linear-economy paradigm based on take-make-dispose. Simultaneously, the linear economy considers end-of-use products as waste rather than as a resource, which results in large volumes...

Development and Internal Validation of a Clinical Risk Score for Hypovitaminosis D in Italian Adults Aged ≥50 Years Attending Osteoporosis and Metabolic Bone Disease Centers

Background/Objectives: Hypovitaminosis-D is a highly prevalent condition worldwide, associated with adverse skeletal and extra-skeletal outcomes. Increasing demand for serum 25-hydroxyvitamin D (25(OH)D) testing points toward the need for simple tools to identify individuals at r...

ODIN: Confirmation and 3D Reconstruction of Six Massive Protoclusters at Cosmic Noon

Abstract Protoclusters represent sites of accelerated galaxy formation and extreme astrophysical activity characteristic of dense environments. Identifying massive protoclusters and mapping their spatial structures are therefore crucial for understanding how large-scale environme...

Snow microinvertebrates from lowlands, high mountains and the Arctic—implications for conservation efforts

Abstract The protection of cryospheric ecosystems and their biota cannot be properly defined without a detailed species inventory. Snow microinvertebrates are crucial for estimating cryophilic biodiversity, yet they are poorly described at broader spatial scales. To fill this kno...

Metastability from recurrence analysis in depression

Abstract This study investigates recurrent patterns in Ecological Momentary Assessment (EMA) data from a single-case longitudinal study (239 days) of a patient diagnosed with major depressive disorder undergoing antidepressant dosage adjustments. We construct a dynamic network ba...