University of Saskatchewan

Biocatalytic Synthesis of Substituted Cinnamaldehydes

Abstract Substituted cinnamaldehydes are valuable compounds, but current syntheses rely on expensive and toxic reagents. We report a biocatalytic synthesis of substituted cinnamaldehydes from the corresponding benzaldehydes via an aldolase, NahE, and benzoylformate decarboxylase....

A Novel Analytical Strategy to Detect Specific Markers of Nitrofurazone from Protein-Bound Metabolites in Food Animals

Abstract Accurate detection of nitrofuran residues, as an indicator of banned drug use, in animal-derived food products is vital for ensuring food safety. The accepted regulatory approach for nitrofurans produces a residue marker from their protein-bound metabolites, which is non...

Observational study of the microbiome of perforated abomasal ulcers in unweaned beef calves in Canada

In western Canada, perforating abomasal ulcers (AU) are generally diagnosed postmortem in beef calves up to 2 months of age. Certain microbes have been associated with AU, but the evidence is circumstantial. Thus, analyzing the abomasal microbiome in calves with and without AU ma...

Exploratory investigation of hemodialysis membrane–induced differential DNA methylation in patient blood

Hemodialysis (HD) patients experience chronic inflammation and immune activation driven by continuous blood contact with synthetic dialysis membranes. Increasing evidence suggests that membrane surface chemistry can modulate immune–epigenetic regulatory mechanisms, including DNA...

Comparing annual and perennial forage systems: Effects on yield, quality, steer performance, emissions, and profitability

ABSTRACT Objective This study compared annual and perennial forage systems for yield, quality, grazing animal perfor-mance, enteric emissions, and economic viability. Materials and Methods Four forage systems were evaluated, consisting of 2 annual systems: (1) BAR-PEA-BRAS: CDC A...

Quasi-Experimental Trial Examining the Effectiveness of Driver Training Modules on Simulated Driving Performance in Young Drivers

Young and novice drivers have the highest representation of driver injuries and fatalities. While driver education provides in-class and in-car exposure to the driving environment, the use of driving simulators can further expose challenging driving environments that are not typi...

Physics-Guided Sequential State Space Transformer (PS3T) for Projection Domain LDCT Denoising

Low-Dose Computed Tomography (LDCT) reduces radiation exposure but introduces severe quantum noise and streak artifacts that degrade image quality. To address these challenges, we propose the Physics-Guided Sequential State Space Transformer (PS3T), a projection-domain denoising...

Beyond underrepresentation: narratives of identity and healing among Indigenous post-secondary student-athletes

Indigenous student-athletes remain underrepresented in post-secondary sport, yet limited research has examined how they experience and make meaning of participation within sporting and educational contexts. Guided by narrative inquiry and Clandinin and Connelly’s three-dimensiona...

Protective effect of lycopene against sodium nitroprusside-induced oxidative stress in Artemia salina

Lycopene is a carotenoid with potent antioxidant properties, that is widely used in the food, pharmaceutical, and cosmetic industries, thereby increasing the likelihood of its release into aquatic environments through industrial effluents. Artemia salina is a well-established eco...

Macrophage migration inhibitory factor is a potential therapeutic target for cisplatin induced peripheral neuropathy in breast cancer

Abstract Background Cisplatin (CP) is a potent chemotherapy drug used for the management of several cancers. However, the use of CP is associated with painful peripheral neuropathy. Effective therapies are currently unavailable for cisplatin-induced peripheral neuropathy (CisIPN)...

Tree-based structural equation model for assessing measurement invariance in patient-reported outcome measures

Evidence of measurement invariance (MI) is essential to ensure that scores based on patient-reported outcome measures (PROMs) are comparable across groups or over time. Conventional methods for evaluating MI in PROMs are mostly group-based methods that require that relevant diffe...

Effectiveness of Selective Cyclooxygenase-2 Inhibitors for Postoperative Pain Management Using Multidimensional Pain Assessment: A Systematic Review and Meta-analysis of Randomized Controlled Trials.

BACKGROUND: Although selective cyclooxygenase-2 (COX‑2) inhibitors are commonly used in perioperative pain management, it is uncertain whether these anti-inflammatory agents meaningfully improve postoperative recovery, including the impact of pain on daily functioning. METHODS: T...

Assessment of Clinical and Immunological Factors of Local Recurrence in Canine Soft Tissue Sarcoma

Canine soft tissue sarcomas (STSs) are locally invasive tumours, making local recurrence a major clinical challenge. Time to recurrence (TTR) and associated immune factors remain poorly characterized. This study aimed to characterize the immune microenvironment of canine STS and...

Contemporary Fibrotic Interstitial Lung Disease Outcomes: A Multicentre National Cohort Study

ABSTRACT Background and Objective This study determined contemporary transplant‐free survival in fibrotic interstitial lung disease (ILD), identified baseline factors associated with death or transplant, and assessed performance of the ILD‐GAP (Gender, Age, Physiology) index in a...

Frozen grief: a systematic review of ambiguous loss experiences

Purpose This systematic review focused on the impacts of physical ambiguous loss and the coping strategies used to manage this. The review aims to contribute to a gap in the literature and identify areas where future research could progress. Design/methodology/approach Twenty-sev...

The top 100 cited papers in AI and Healthcare: trends, collaborations, and key contributions

Abstract Purpose This study performed a bibliometric analysis of the top 100 most cited papers on artificial intelligence (AI) and its applications in health and medicine. Data was retrieved from the Scopus database in December 2024, focusing on papers published between 2001 and...

Host-specific soil oomycete communities are spatially repeatable across natural grasslands

Soil oomycetes contain some of the most devastating plant pathogens, and are widespread within the soil microbiome, yet how individual plant species structure oomycete communities in natural soils, and whether any such structuring is consistent across space, remains poorly resolv...

Broiler behavioural changes in response to intermittent lighting schedules

1. Provision of light and dark periods can influence broiler behaviour and impact bird welfare. Determining how offering light in different patterns, such as intermittent (INT) lighting, impacts birds is necessary to determine ideal management practices. The objective of this res...

Identifying social structural factors associated with HIV community based organization service use and community participation among women living with HIV in Metro Vancouver

Abstract Background HIV Community-Based Organizations (CBOs) remain underfunded, limiting programming and support, with limited research examining factors influencing women’s engagement with HIV CBOs. Therefore, social-structural factors associated with HIV CBO service use and co...

Measuring what matters: a rasch-validated instrument for functional sexual and reproductive health literacy among Ghanaian adolescents

Abstract Background Functional sexual and reproductive health (SRH) literacy is fundamental to informed decision-making among adolescents. Yet existing measures hardly address the needs of low-literate populations in Sub-Saharan Africa. This study developed and validated a test o...