University of San Francisco

The immunophenotype and proviral landscape of HIV-infected CD4 T cells during antiretroviral therapy

In individuals on effective antiretroviral therapy, integrated HIV proviruses persist within CD4 T cells, forming a viral reservoir that rebounds if treatment is stopped. Identifying and targeting these rare, infected cells is critical for advancing therapies, but methods to stud...

Novel Use of Penile Ultrasound in the Evaluation of Patients With Adult Acquired Buried Penis

Adult acquired buried penis (AABP) disease is a risk factor for penile cancer. For a subset of patients, the severity of their disease precludes complete physical examination of the penile shaft due to the inability to exhume the penis. Thus, providers are unable to identify peni...

Combined Post- and Precapillary Pulmonary Hypertension in Patients With Advanced Heart Failure

Pulmonary hypertension associated with left heart disease, or group 2 pulmonary hypertension, is common in patients with advanced heart failure. In at least a third of these patients, the pulmonary pressures are disproportionately elevated relative to left heart filling pressures...

Randomized Quality Improvement Trials: An Overview and Proposed Framework for Ethical Oversight

Quality improvement (QI) is a routine part of health care delivery, but ineffective QI can have unintended consequences, waste resources, and paradoxically worsen health care quality. Randomized QI (RQI) trials use randomization to assign the QI intervention to some but not all p...

Spatial Regulation of Preameloblast Development in Response to Distal Mouse Incisor Injury

Enamel, the outermost mineralized tissue of the tooth, is produced by specialized dental epithelial cells called ameloblasts. Unlike human enamel, which lacks regenerative capacity, the mouse incisor grows throughout life, driven by adult stem cells residing in the labial cervica...

Cofactor-Free Tau FilamentsAre Dynamic and UndergoStructural Evolution Driven by Thermodynamic Control

Abstract Tau filaments are a hallmark of neurodegenerative tauopathies, such as Alzheimer’s disease (AD). Structural studies have revealed that patient-derived tau fibrils adopt distinct folds in different tauopathies; however, it is unclear what forces guide this process. To exp...

Authentic and Sustained Family Partnership in Neonatal and Pediatric Research

Improving the health and well-being of children requires sustained partnerships with parents, community members, advocates, and researchers to identify and answer high-impact research questions. Meaningful engagement with families and communities in the design, conduct, and disse...

A Phase II Trial of Pembrolizumab plus Granulocyte-Macrophage Colony-Stimulating Factor in Advanced Biliary Cancer

PURPOSE: Immune checkpoint inhibitors have limited activity as monotherapy in biliary cancers. Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a pleiotropic immune cell growth factor which achieved prolonged survival when combined with ipilimumab in melanoma. We cond...

DESI Strong Lens Foundry. IV. Spectroscopic Confirmation of DESI Lens Candidates with VLT/MUSE

Abstract We present integral field spectroscopic observations of 76 strong gravitational lens candidates identified with a residual neural network in the DESI Legacy Imaging Surveys, obtained with the Multi Unit Spectroscopic Explorer (MUSE) on ESO’s Very Large Telescope. These o...

Mapping System Vulnerabilities in Anaesthesia Safety: A Role‐Based Inquiry in Response to Fatal Fungal Meningitis Outbreaks in Mexico

ABSTRACT Objectives Unsafe anaesthesia practices in Mexico have contributed to repeated outbreaks of fatal fungal meningitis, exposing broader health system vulnerabilities. This study aimed to analyse how structural weaknesses in perioperative care, spanning governance, workforc...

USFGeoAI: Applying LLMs and Foundation Models to Assist in Image Retrieval

Abstract. Geospatial analysis is often hampered by two major obstacles: a scarcity of high-quality, annotated satellite imagery, and the complexity of interacting with machine learning tools for image analysis. To address this, we introduce USFGeoAI, a proof-of-concept system tha...