University of Palermo

Neanderthal’s heel: How the Neanderthal’s external calcaneal shape uniquely differs from that of modern humans

Neanderthals exhibit unique morphological adaptations in their calcaneus compared to Homo sapiens , shedding light on distinct evolutionary pressures and functional requirements shaping their respective foot anatomy. This study assesses which calcaneal traits represent plesiomorp...

Global Real‐World Outcomes of Olaparib in Metastatic Castration‐Resistant Prostate Cancer Patients With Homologous Recombination Repair Alterations

Evidence to guide the treatment for patients with metastatic castration-resistant prostate cancer (mCRPC) and Homologous Recombination Repair (HRR) gene alterations outside of clinical trials remains limited. This was an observational, cohort study, including mCRPC patients with...

Tapered drip laterals for sloping agricultural fields

Abstract Tapered drip laterals offer a promising solution to enhance hydraulic performance and reduce energy consumption in horizontal or sloping agricultural fields. However, their design typically relies on iterative numerical procedures, which limit their practical implementat...

Multi-objective optimisation of renewable energy integration in circular brine valorisation/treatment: The case of the CARMEn chain

Circular brine-valorisation chains offer a promising route to address water scarcity and critical raw-material recovery, but their large electrical and thermal energy demands can offset environmental benefits if powered by fossil sources. This work develops a fully integrated, ho...

Halloysite Nanotubesas Dynamic Interfaces for FunctionalEnzyme Biomaterials

Abstract The development of robust and recyclable enzyme-based materials is essential for advancing sustainable biocatalysis and biotechnologies. Herein, we report the design of covalent enzyme-halloysite biohybrid materials obtained by the controlled functionalization of halloys...

In vivo T‐cell depletion and pharmacokinetic‐based busulfan conditioning regimen improve the outcomes in acute myeloid leukemia (AML) in complete remission undergoing to allogeneic stem cell transplantation

Pharmacokinetic‐based busulfan administration improves the therapeutic window and in vivo T‐cell depletion with antilymphocyte globulins reduces graft‐versus‐host disease incidence. In this study, both were used, showing an improvement of clinical outcomes in patients with acute...

Factors associated with sleep disturbances in nursing students at the University of Palermo

<title>Abstract</title> <bold>Introduction</bold> : sleep disorders are very common among university students and can have negative effects on physical and mental health and academic performance. There is a close correlation between sleep disorders and psychological and behaviour...

A Dynamic Mechanism for Prevalence of Triangles in Competitive Networks

Abstract Triangles are abundant in real-world networks but rare in standard null models for sparse graphs. Existing explanations typically rely on explicit triadic closure mechanisms or geometry-based connection rules. We propose an alternative hypothesis: the frequent appearance...

Chronological Age and Adaptive Outcomes Following Neuropsychomotor and Aquatic Interventions in Children with Autism: A Secondary Analysis

Background: Autism Spectrum Disorder (ASD) can be conceptualized not as a static condition but as a dynamic disorder of developmental regulation, in which neuroplastic potential is translated into functional gains only through structured, experience-dependent therapeutic input. N...

A Potential Link Between Dyslipidemia and Inflammation in Patients with Schizophrenia: Insights from Sterols and HDL Profile Analysis

Dyslipidemia and inflammation are two hallmarks of schizophrenia (SCZ), but the link between these two conditions remains elusive. We studied 40 SCZ patients and 40 age- and sex-matched healthy controls (CTRL) analyzing serum total, low-density lipoprotein (LDL), and high-density...

Personalized Medicine for the Management of Non-Communicable Diseases (NCDs)

Non-communicable diseases (NCDs) are the leading cause of death worldwide and are among the major drivers of healthcare expenditure, particularly in societies undergoing progressive population aging [...]

Integrative taxonomy reveals multiple Mediterranean invasions by Indo-Pacific Dorvillea (Annelida, Dorvilleidae)

Abstract Biological invasions are a major driver of global biodiversity loss, with the Mediterranean Sea among the most heavily invaded marine regions. However, identification and monitoring of Non-Indigenous Species (NIS) are hindered by taxonomic uncertainty and cryptic diversi...

Review of Clifford algebra-based AI methods in signal analysis

Abstract Hypercomplex number systems, such as complex numbers and quaternions, have found many uses in the area of signal analysis. Clifford algebras, along with the embedding of (usually) a real vector space, can be used to represent some of the commonly used hypercomplex algebr...

Limited Discriminatory Capacity of Continuous Glucose Monitoring in Prediabetes and Increased Diabetes Risk: A Cross-Sectional Study

Background and Objectives: To determine whether continuous glucose monitoring (CGM)-derived metrics can differentiate between normoglycemia, increased diabetes risk (FINDRISC+) and prediabetes and to assess whether CGM-derived metrics provide additional discriminatory information...

Concurrent Assessment of Micro- and Nanoplastics and Bisphenol A in Non-Dialysis Chronic Kidney Patients and Hemodialysis Patients: Results from a Cross-Sectional Human Biomonitoring Study Focusing on Sex-Related Patterns

Patients with chronic kidney disease (CKD), particularly those receiving hemodialysis (HD), may be more vulnerable to exposure to micro- and nanoplastics (MNPs) and bisphenol A (BPA) because of impaired renal clearance and frequent contact to plastic-based medical devices. This s...

AnticancerPotential of Camalexin-Derived Ru(II) Metallacycles

Abstract Camalexin, a primary indole-analogous phytoalexin from Arabidopsis thaliana and other crucifers, inhibits the proliferation of various cancer cells. In this contribution, the synthesis and characterization of camalexin-derived Ru(II) half-sandwich complexes are described...

Ferdinandea Island and Graham Bank, Sicily Channel: An Integrated Historical, Geological and Geomorphological Synthesis of a Shallow Submarine Monogenetic Volcanic Field

Ferdinandea Island, part of a shallow-water submarine volcanic field, emerged in the Sicily Channel between Italy and Tunisia in July 1831 and was eroded below sea level within months; its submerged remnant forms the shallowest water depth region of Graham Bank. Here, we review n...

Expiratory phase lung mechanics in late-onset Pompe disease: a multicenter study using oscillometry to identify specific breathing abnormalities

Abstract Introduction In late-onset Pompe disease (LOPD), muscle weakness causes restrictive lung impairment. In murine models, glycogen deposition in lung parenchyma suggests additional causes for restriction that remain poorly understood. We investigated whether oscillometry de...

Vaccination in pediatric transplantation—General recommendations. A position paper by the European Reference Network TransplantChild

Infectious diseases remain a leading cause of morbidity and mortality among pediatric transplant recipients, despite significant advances in transplantation management. Vaccination is the most effective strategy to prevent infections; however, its efficacy is hindered in solid or...

Ammonia-Responsive Gelatin/Co–MOF Composite Films Based on Gallic Acid-Derived Metal–Organic Frameworks for Intelligent Food Packaging

Ammonia-responsive gelatin-based composite films containing cobalt metal–organic frameworks (Co–MOFs) synthesized using gallic acid as an organic ligand were developed and evaluated as intelligent packaging materials. Co–MOFs were incorporated into gelatin films at concentrations...