University of Nebraska Medical Center

Updated COVID ‐19 Vaccines and Health Outcomes in Patients With Autoimmune Rheumatic Conditions

OBJECTIVE: We aimed to assess the association between COVID-19 vaccination status and COVID-19-related hospital admissions, need for mechanical ventilation or extracorporeal membrane oxygenation (ECMO), and death in people with autoimmune rheumatic conditions. METHODS: We conduct...

Comparison of Caregiver and Child Mand Modality Preferences Using Sequential Extinction During Functional Communication Training

ABSTRACT Functional communication training has been found to be an effective treatment for individuals with developmental disabilities who exhibit challenging behavior. Despite strong empirical support, variables such as preference for the functional communication response modali...

Pharmacokinetics and Toxicity Assessment of Artesunate and Its Metabolite, Dihydroartemisinin, in NOD Scid Gamma Mice

Artesunate (ART) is an FDA-approved antimalarial drug and is currently being repurposed for various solid tumor treatments. However, there are no safety or pharmacokinetic (PK) studies in mice exploring its potential application in murine brain tumor models. This study aims to de...

High Embolic Risk with Orbital Atherectomy for Calcified Peripheral Artery Disease

ABSTRACT Purpose Orbital atherectomy (OA) is used to treat heavily calcified peripheral artery disease, aiming to improve vessel compliance and reduce the need for high-pressure angioplasty and stenting. However, clinical data raise concerns regarding distal embolization, vessel...

Care Models for the Genetic Evaluation of Dilated Cardiomyopathy at Sites of the DCM Consortium

Abstract Background Clinical genetic evaluation for patients with dilated cardiomyopathy (DCM) is minimally implemented and models of care are not defined. To understand current genetics care for DCM, a systematic needs assessment was conducted. Methods Principal Investigators (P...

Financial Impact of a Long-Acting Injectable Cabotegravir/Rilpivirine Program: A Real-World Experience

Abstract Background Long-acting injectable (LAI) cabotegravir/rilpivirine (CAB/RPV) is an effective HIV treatment, but barriers, such as financial considerations limit implementation. Understanding the real-world financial impact is essential for program sustainability and equita...

Evaluating Variations of Feeder Attention in Mitigating the Side Effects of Escape Extinction

Research has shown that removing bites is the primary motivator for children with feeding difficulties to engage in inappropriate mealtime behavior (IMB) and escape extinction (EE) is the most well-established treatment component. Escape extinction may result in temporary but neg...

Immune Checkpoint Inhibitor–Associated Acute Kidney Injury

Immune checkpoint inhibitors (ICIs) have reshaped modern oncology by improving outcomes in multiple cancers. They function by enhancing T-cell–mediated antitumor immunity through the blockade of inhibitory pathways, such as cytotoxic T-lymphocyte–associated protein 4 (CTLA-4), th...

Turns and downturns in aging drivers

As cognitive decline progresses, older adults may self-regulate their driving. Avoidance of left turns across traffic is observable in naturalistic driving data but rarely self-reported. We studied 106 older adults using baseline and one-year follow-up neuropsychological assessme...

Stellate Ganglion Nrf2 Modulates Oxidative Stress and Heart Rate Responses in Mice and Rats with Heart Failure

Chronic heart failure (CHF) is a growing global health concern characterized, in part, by progressive sympathetic overactivation, which exacerbates this condition. Accumulating evidence identifies oxidative stress as a key driver of sympatho-excitation, mediated by excess reactiv...

The Inv(16) Oncogene CBFB::MYH11 is Required for the Survival of Leukemia Cells in the Blood and Spleen, but not the Bone Marrow

Inversion of chromosome 16 [inv(16)] generates the fusion gene CBFB::MYH11 (CM) and is one of the most common chromosomal rearrangements in Acute Myeloid Leukemia (AML). Expression of CM is required for leukemia initiation. Patients with inv(16) at diagnosis invariably have the r...

Virtual coronary artery bypass grafting

<title>Abstract</title> Coronary artery bypass grafting (CABG) offers superior long-term survival over percutaneous coronary intervention (PCI) or medical therapy in patients with complex coronary artery disease (CAD). This prospective proof-of-concept study aims to develop and v...

Adapting to virtual service delivery to increase resilience of domestic violence services

Purpose The rapid shift to virtual services precipitated by the COVID-19 pandemic related restrictions forced domestic violence agencies to alter many types of service provision. A survey of service providers assessed these disruptions and identified services where virtual adapta...

Development and validation of natural language processing pipelines to extract injury and surgery-related data elements from ACL reconstruction operative reports

BACKGROUND: Over 100,000 patients undergo ACLR each year in the United States, providing rich electronic medical record data to improve outcomes, but manual chart review can be time-consuming and expensive. Natural language processing (NLP) methods have been successfully used to...