University of Nebraska Medical Center

The Inv(16) Oncogene CBFB::MYH11 is Required for the Survival of Leukemia Cells in the Blood and Spleen, but not the Bone Marrow

Inversion of chromosome 16 [inv(16)] generates the fusion gene CBFB::MYH11 (CM) and is one of the most common chromosomal rearrangements in Acute Myeloid Leukemia (AML). Expression of CM is required for leukemia initiation. Patients with inv(16) at diagnosis invariably have the r...

Virtual coronary artery bypass grafting

<title>Abstract</title> Coronary artery bypass grafting (CABG) offers superior long-term survival over percutaneous coronary intervention (PCI) or medical therapy in patients with complex coronary artery disease (CAD). This prospective proof-of-concept study aims to develop and v...

Adapting to virtual service delivery to increase resilience of domestic violence services

Purpose The rapid shift to virtual services precipitated by the COVID-19 pandemic related restrictions forced domestic violence agencies to alter many types of service provision. A survey of service providers assessed these disruptions and identified services where virtual adapta...

Development and validation of natural language processing pipelines to extract injury and surgery-related data elements from ACL reconstruction operative reports

BACKGROUND: Over 100,000 patients undergo ACLR each year in the United States, providing rich electronic medical record data to improve outcomes, but manual chart review can be time-consuming and expensive. Natural language processing (NLP) methods have been successfully used to...