University of Modena and Reggio Emilia

Oveporexton for Narcolepsy Type 1 — Results from Two Phase 3 Trials

BACKGROUND: Narcolepsy type 1 is characterized by excessive daytime sleepiness, cataplexy, disrupted sleep, sleep paralysis, and hypnagogic or hypnopompic hallucinations. Oveporexton (TAK-861), an oral orexin receptor 2-selective agonist, reduced symptoms of narcolepsy type 1 in...

The Association Between Muscle Strength, Thigh Circumference, and Serving Efficiency in Elite Male Volleyball Players: A Prospective Observational Longitudinal Study

Background and Aim: The identification of factors that optimize competitive performance is a primary focus for athletes and coaches in any sport, particularly variables that are modifiable through tailored nutritional and training strategies. Since data regarding volleyball remai...

Chiral-Induced Spin Selectivity as a Driving Force in Enantiorecognition: A Generator-and-Reader Perspective

Abstract Enantiorecognition is conventionally rationalized through stereochemical models, such as lock-and-key, induced-fit, and three-point interaction schemes, in which a chiral selector discriminates between enantiomers through geometry and noncovalent interactions. Neverthele...

Comparative abiotic, regulatory-aligned assessment of nutrient and trace-metal release from secondary geomaterials for soil application

Abstract This study provides an abiotic, regulatory-aligned leaching assessment of two secondary geomaterials intended for soil application: RE.WO, a secondary raw material derived from the thermal transformation of mineral wool construction waste, and BO50, a by-product of rock-...

Membrane Lipid Remodeling in Non-Saccharomyces Wine Yeasts Under Ethanol Stress: From Mechanism Toward a Predictive Lipid Signature

Non-Saccharomyces yeasts shape the aroma, freshness, and reduced-alcohol profiles of wines, yet their oenological contribution is curtailed by a poor tolerance to ethanol. Because ethanol acts on the plasma membrane, the cell’s selective barrier, this limitation is rooted in the...

Radiotherapy in Combination with CD20×CD3 Bispecific Antibodies for B-Cell Lymphoma: Biological Rationale, Current Evidence, and Open Questions

Background/Objectives: CD20×CD3 bispecific antibodies (BsAbs) have changed the management of relapsed/refractory (R/R) B-cell non-Hodgkin lymphoma. Whether and how radiotherapy (RT) can be safely and usefully combined with BsAb therapy remains undefined. This Perspective reviews...

Cemiplimab in cutaneous squamous cell carcinoma: a longer follow‐up study focusing on the late toxicities

Summary Background and Objectives Cemiplimab was the first systemic therapy approved for advanced cutaneous squamous cell carcinoma (cSCC). Patients and Methods We report findings from the Italian early access program cohort, comprising 134 patients treated with cemiplimab, with...

Lpb. plantarum inhalation powders for the reduction of lung inflammation and S. aureus growth control in non-CF bronchiectasis

INTRODUCTION The reduced diversity of the lung microbiome in respiratory conditions, including bronchiectasis, promotes bacterial infection and inflammation, contributing to worsening clinical outcomes. Traditional treatments often fail to address both infection and inflammation....

Fatal waterhouse–friderichsen syndrome at autopsy: a systematic review and forensic diagnostic framework

Waterhouse-Friderichsen syndrome (WFS) represents a fulminant septic condition characterized by bilateral adrenal hemorrhage and rapid clinical deterioration. Although classically associated with meningococcal infection, fatal cases occur across multiple infectious etiologies and...

A nicotinic-dopaminergic hybrid probe enhances D2-like autoreceptor-mediated inhibition of dopamine release

β2-containing nicotinic acetylcholine receptors (nAChRs) and dopamine D 2 receptors (D 2 Rs) cooperate to shape striatal dopamine (DA) output, yet the mechanisms by which nicotinic-dopaminergic crosstalk influences D 2 -like autoreceptor-mediated inhibition of DA release remain u...

Quantification of Phosphorylated Tau Protein in Alzheimer's Disease Patients’ Fluids With Electrolyte‐Gated Organic Transistor Biosensors

ABSTRACT Dementia is a syndrome that affects millions of people in the world, and Alzheimer's disease (AD) is the most common cause. The diagnosis of AD begins with cognitive symptoms such as mild cognitive impairment (MCI) but requires the demonstration and quantification of the...

Functional Evolution and Modular Behaviour in the Carnivoran Mandible

The relationship between form and function holds a central spot in evolutionary biology, as the changes in such relationship through time, are likely to deeply influence how organisms adapt to the surrounding environment. However, anatomical structures may be interpreted as a com...

Gas-phase synthesis of plasmonic nanoparticles with robust high bandgap shell materials: A study of Cu@CaF2 with AI supported transmission electron microscopy analysis

Cu@CaF2 plasmonic nanoparticle (NP) films are physically synthesized, and their morphology, and electronic and optical properties are thoroughly investigated. Cu NPs are generated using a gas aggregation source assisted by magnetron sputtering, while CaF2 coatings are deposited b...

Liver Transplantation Following Hepatocellular Carcinoma Rupture and Long-Term Immunotherapy: A Case Report

Abstract Aim To report a case of advanced hepatocellular carcinoma (HCC) complicated by tumor rupture, successfully downstaged with combined oncolytic immunotherapy (Pexa-Vec) and a PD-1 inhibitor (Nivolumab), ultimately enabling liver transplantation (LT). This report highlights...

From regulatory approval to clinical practice: real-world eligibility for anti-amyloid monoclonal antibodies in an Italian dementia-care network

Background: European approval of lecanemab and donanemab has shifted anti-amyloid monoclonal antibodies from trial evidence to health-system implementation. In Italy, reimbursement decisions are pending, and real-world estimates of treatment-ready eligibility under Italian approp...

Titanium Oxynitrideby TiO2 Nitridation:A Comparative Study of Film, Nanoparticle, and Metasurface NanostructureProperties

Abstract Titanium oxynitride (TiOxNy) is a unique plasmonic material bridging dielectric TiO2 and metallic TiN. In this study, the properties of TiOxNy films, film-derived metasurfaces, and colloidal nanoparticles, all synthesized by the temperature-controlled ammonia nitridation...

Long-Term Assessment of UHI and SUHI in Modena: Integrating Landsat Land Surface Temperature and Meteorological Observations

The urban heat island (UHI) refers to higher air temperatures (Tair) in urban areas than in surrounding rural environments, while the surface urban heat island (SUHI) describes analogous differences in land surface temperature (LST). This study presents a long-term assessment of...

Sub‐ UV Trichoscopy for the Assessment of Acute and Subacute Form of Alopecia Areata

The authors declare no conflicts of interest. The data that support the findings of this study are available from the corresponding author upon reasonable request.

Inaugural editorial for Discover Condensed Matter

Welcome to Discover Condensed Matter , an international, peer-reviewed open-access journal published by Springer Nature, dedicated to disseminating research and science across all topics related to condensed matter physics and solid-state materials.

33rd GP2A Annual Medicinal Chemistry Conference, XIVth Paul Ehrlich MedChem Euro-PhD Network Meeting & COST Action One Health Drugs Against Parasitic Vector Borne Diseases in Europe and Beyond (OneHealthdrugs)

The 33rd Annual Conference of the Group for the Promotion of Pharmaceutical Chemistry in Academia (GP2A), held in Nantes from 11 to 13 June 2025, marked a significant expansion of the organization’s scope and collaborative efforts. Building on the success of the previous meeting...