University of Mississippi

Phenolic Metabolites as Therapeutics for Chronic Diseases: One Researcher’s PAINS Is Another’s Translatable Polypharmacology

Abstract Phenols, natural and semisynthetic compounds in which a hydroxylated or oxygenated aromatic scaffold is a defining structural feature, occupy a paradoxical position in drug discovery. On the one hand, these compounds are frequently scrutinized for triggering Pan-Assay IN...

Uncertainty-aware prediction of asphalt pavement roughness using probabilistic machine learning

Accurate prediction of asphalt pavement deterioration is critical for data-driven infrastructure asset management. However, conventional data-driven models commonly provide deterministic estimates, offering limited insight into prediction confidence. This limitation restricts the...

Calibration and Design Considerations for Multidimensional Multistage Testing

Abstract Multidimensional multistage testing (MMST) combines multidimensional item response theory (MIRT) with adaptive multistage testing design to measure multiple related constructs efficiently. Despite its potential for large‐scale assessments, little research has examined ca...

Integrated LC-DAD-QToF-MS Characterization and Quantitative Profiling of Polyphenolic Metabolites in Idesia polycarpa

Idesia polycarpa, a dioecious tree distributed in East Asia, is known for its pharmacologically relevant secondary metabolites. In this study, a comprehensive phytochemical investigation was conducted to characterize and quantify the major polyphenolic metabolites across differen...

Ex situ thermal acclimation alters temperature selection with limited post-release effects in an endangered frog ( Rana muscosa )

Abstract Amphibian declines driven by the fungal pathogen Batrachochytrium dendrobatidis (Bd) pose major challenges for conservation, particularly for cold-adapted species occupying habitats where temperatures may be less limiting to Bd growth. Host thermal behaviour can influenc...

Ligand−Surface Interactions and Band Structure Engineering in Cd-Doped MAPbI3 Quantum Dots for Photodetector Applications

Abstract Cadmium-doped methylammonium lead iodide (MAPbI3) quantum dots (QDs) offer a promising route to engineer defect states, enhance structural stability, and tune optoelectronic performance, yet their fundamental photophysics, surface chemistry, and ligand interactions remai...

Tubulin E-Hook Hexamers Reveal Sequence-Dependent Compaction and Transient Secondary Structure Signatures

The present work shows that E-hook fragments possess functional structural differences governed by electrostatic interactions and sequence composition. The acidic C-terminal tails of tubulin, known as E-hooks, play a central role in regulating interactions between microtubules an...

Energy market and carbon emission spillovers in critical minerals investment: a dynamic connectedness approach

Purpose This paper aims to examine the daily financial risk spillovers associated with investing in critical minerals. It examines the dynamic interconnectedness between seven critical mineral Exchange-Traded Fund (ETF) portfolios and key economic-wide variables, including the en...

Tissue-specific anthocyanin quantification, comprehensive phytochemical profiling, and chemometric analysis of fruit and aerial parts of Rubus buergeri Miq.

Rubus buergeri , a winter-fruiting species native to East Asia, remains poorly characterized phytochemically. This study presents the first comprehensive phytochemical profiling of fruits and aerial parts collected from Jeju Island, Korea. A validated ultra-high-performance liqui...

The effect of area deprivation on missed cardiology appointments and subsequent acute hospital visits

INTRODUCTION: Children with CHD require long-term follow-up, but missed visits among patients are common. Missed appointments likely contribute to excess morbidity and mortality. Our study seeks to identify social factors that could predict patients at risk of missing cardiology...

Phytochemistry and Pharmacological Evidence of East Asian Crowberry Reported as Empetrum nigrum var. japonicum or E. nigrum subsp. asiaticum: A Critical Review of Potential Chemotypic Differentiation

East Asian crowberry has been reported under Empetrum nigrum var. japonicum and E. nigrum subsp. asiaticum. This critical narrative review evaluates taxonomy, phytochemistry, and pharmacological evidence from Korean, Japanese, and Chinese source-reported material in the context o...

Travel Time and Cost-Benefit Evaluation of Alternative Intersections with Three-Critical-Phase Traffic Signals in North Carolina

Abstract This paper explores the potential benefits of three-phase intersections as a compromise between two-phase and conventional four-phase designs, particularly in terms of improving travel time efficiency and safety. While two-phase intersections offer advantages in reducing...

Numerical Study of Sediment Transport with Flow Hydrographs of Varying Length in a Laboratory Flume

Abstract This paper presents a numerical sediment transport model based on data from a series of experiments with flow hydrographs of varying lengths in a laboratory flume with a sand bed. The model was calibrated and validated using one flow hydrograph and then applied to other...

Direct Observation of a Cross-Coupling Catalyst Intermediate via Single-Molecule Spectroscopy

Abstract Single-molecule measurements on molecular catalysts are uniquely poised to allow observation of unsynchronized chemical dynamics and transient intermediates that are not observable using traditional bulk techniques. However, single-molecule fluorescence spectroscopy is t...

A Weight-Activated Main Path Analysis of Policing and Life Course Scholarship

Abstract Criminology is a constellation of many different interrelated subfields that study the various institutions constituting and person(s) involved in the criminal justice system. While the researchers that contribute to these subfields are independent, the contributed resea...

History of worsening heart failure and outcomes with vericiguat in ambulatory HFrEF: an exploratory post-hoc analysis of VICTOR

Stefan Störk, Javed Butler, Caroline Morbach, Fabian Kerwagen, Johann Bauersachs, Ephraim B Winzer, Justin Ezekowitz, Carolyn S P Lam, Inga Bayh, Stefan He

Secure UPnP Resource Discovery Using a PUF-Assisted Hardware Accelerator for IoT

Universal Plug and Play (UPnP) is widely used for resource discovery in internet of things and smart-edge environments because of its lightweight and decentralized operation. However, conventional UPnP and Simple Service Discovery Protocol (SSDP) mechanisms expose static identifi...

Isolation of Phytoecdysteroids:Ajugasterone C and20-Hydroxyecdysone, from Sida alba Linn.

Abstract Medicinal plants are employed in folk medicine as enormous reservoirs of secondary metabolites, with varied and distinctive chemical and biological properties, that can prevent, treat, or cure diseases. Consequently, the validation of traditional remedies has remained a...

Cobranding in Sport Video Games: A Case Study of Electronic Arts (EA) FC and Nike

Sports video games (SVGs) have become a lucrative platform for brand marketing through in-game advertising (IGA). However, SVG literature has portrayed IGA as a passive form of in-game brand communication (i.e., billboards). Additionally, the literature has primarily focused on h...

Galactose-FunctionalRAFT Agent for Biorelevant PolymericMaterials

Abstract In this work, we report a novel chain transfer agent (CTA) derived from d-galactose and evaluate its potential as a reversible addition–fragmentation chain-transfer (RAFT) agent. Using this galactose-based CTA, Gal-RAFT, both hydrophilic and hydrophobic monomers were suc...