University of Milano-Bicocca

Enhancing Numerical Stability in Portfolio Optimization via Numerical Rank: The $$\delta $$-Stable Part of the Efficient Frontier

Abstract The fact that the solution of the Markowitz model is numerically unstable is recognized as one of the principal reasons for its poor out-of-sample results when applied in practice. In the present paper, we show that, alongside standard instability sources such as the est...

Dementia risk factors and biomarkers in subjective cognitive decline: real world evidence from the monza brain health service

Abstract Aims Up to 45% of dementia can be prevented by addressing modifiable risk factors. Brain Health Services (BHS) are emerging across Europe, targeting individuals with subjective cognitive decline (SCD) to assess, communicate and reduce their risk of dementia. Our aim is t...

Probing dark matter interactions with a RES–NOVA prototype cryogenic detector

Abstract We report on the operation of a 13 g PbWO $$_4$$ 4 crystal, grown from archaeological Pb and operated as a cryogenic calorimeter in an underground environment. Read out with a Ge thermistor, the detector achieves a low energy threshold and, for the first time, enables th...

Youth and climate change imaginaries in a hydrogeological risk neighbourhood

This contribution examines how young people construct and negotiate climate imaginaries in Niguarda, a neighbourhood of Milan, Italy, officially recognised as highly exposed to hydrogeological risk. Drawing on qualitative research with 47 upper secondary students, the study combi...

‘We Have to Think Out of the Box They Put Us in’: A Collective Narrative Study of Refugee and Asylum Seeker Subjectivities in South Africa

ABSTRACT Forced displacement is often framed through dehumanising and pathologising narratives that portray refugees as passive victims or perceived threats, obscuring their agency and lived complexity. This qualitative research–intervention explores the everyday experiences of r...

Closing the Loop: High‐Precision 3D Photofabrication in Living Tissues

ABSTRACT Multiphoton absorption enables three‐dimensional fabrication of photoresists ranging from ceramics to hydrogels and has recently been extended to the writing of microstructures within the dermis, muscle, and brain of living animals. However, an intrinsic difficulty preve...

Response of the Carbonate System to Ocean Alkalinity Enhancement: A Mesocosm-Scale Experiment

Abstract We present the results of a mesocosm-scale experiment conducted in 2023 in the eastern Mediterranean Sea (Crete, Greece) to evaluate the effects of ocean liming via the addition of calcium hydroxide. We assessed two dosage regimes through repeated additions─low (20 μmol...

From environmental burden to resource potential: environmental impact evaluation and Critical Raw Materials recovery from abandoned gold mining waste in the Western Alps (NW Italy)

Extractive waste (EW) from former mining activities poses long-term environmental impacts while representing a potential secondary resource. Within a circular economy framework, EW can be valorised to recover raw materials (RMs) and critical raw materials (CRMs) contributing to t...

Teaching Climate Change and Geography: Towards a Climate Education Pathway

ABSTRACT This is a crucial moment to reflect on climate education. Young people demand and deserve deeper knowledge, skills and understanding of climate change. Following the 2025 English Curriculum and Assessment Review, this commentary reflects on the relationship between geogr...

Sequential transplantation of allogeneic hematopoietic stem cells and liver in x-linked hyper-IgM syndrome: the role of CMV prophylaxis with letermovir

X-linked hyper-IgM syndrome (XHIM) is a rare inborn error of immunity caused by CD40 ligand deficiency, resulting in combined humoral and cellular immune dysfunction with susceptibility to opportunistic infections, particularly Cryptosporidium-associated sclerosing cholangitis. A...

A Scoping Review of Neurobiological and Brain Structural Alterations Following Child Exposure to Intimate Partner Violence

Intimate partner violence (IPV) is one global issue that can lead to neurobiological consequences and affect brain development across the lifetime. However, evidence is scattered across domains and age groups, making it difficult to map the breadth of empirical findings regarding...

Left behind places and regional resilience to COVID-19 shock in Europe

Current turbulent times pose challenges not only for countries, but also – and above all – for regions within them. However, economic resilience of left behind places is still underexplored, especially in the light of entrenched regional disparities. The aim of this paper is to i...

The Simons Observatory: Development of a Pipeline to Detect Rapid Transients in Time-Ordered Data

We introduce a method for detecting astrophysical transients evolving on timescales of milliseconds to minutes using cosmic microwave background (CMB) survey telescopes. While previous transient searches in CMB data operate in map space, our pipeline directly processes the raw ti...

Evaluating the Role of Anti-PEG Antibodies in Hypersensitivity to PEG-Asparaginase Through Clinically Relevant Cut-Points Defined by ELISA and Surface Plasmon Resonance

Background/Objectives: Conjugation of polyethylene glycol (PEG) to L-asparaginase (ASP) reduces immunogenicity and prolongs the half-life of this biological drug used to treat acute lymphoblastic leukemia (ALL). However, some patients develop anti-drug antibodies (anti-ASP and an...

Tolerance and bioremediation potential of the macroalga Caulerpa prolifera to ultraviolet filters pollutants

Ultraviolet filters (UVFs) as benzophenone-3 (BP-3; oxybenzone) and 4-methyl-benzylidene camphor (4-MBC; enzacamene) have recently been included among the Contaminants of Emerging Concern in marine ecosystems. The aim of this study was to investigate the tolerance and the remedia...

Self-care–based clinical and metabolic profiles among adults with type 2 diabetes: a cross-sectional cluster analysis

Type 2 diabetes mellitus is a heterogeneous condition influenced by clinical, metabolic, and behavioral factors. Traditional approaches to diabetes management often rely on single clinical indicators and may overlook meaningful patterns in patients’ self-care behaviors. This stud...

An application of random forest regression for predicting healthcare costs using administrative databases

BACKGROUND: segmentation. METHODS: This retrospective population-based study used administrative healthcare data (2011-2023) from the Health Protection Agency of Bergamo (Italy). We traced 5-year healthcare resource utilization to predict individual's healthcare costs in the foll...

Lysosomal signaling pathways influence heart rhythm, and regulate atrial function

AIMS: In the heart, endogenous nicotinic acid adenine dinucleotide phosphate (NAADP) triggers lysosomal calcium (Ca2+) release to augment sarcoplasmic reticulum (SR) Ca2+ sequestration, producing larger Ca2+ transients. However, the role of lysosomal Ca2+ signals in pacemaker act...

Strong Coupling in Bulk Nanoplasmonic Nanoplatelet Perovskite Scintillators

ABSTRACT Control of light emission underpins photonics and radiation detection. Strong coupling between excitons and confined electromagnetic modes forms light–matter states known as polaritons, enabling emission control. In scintillators, such effects have been investigated main...

Mangrove reproductive dynamics and the role of honeybee introduction in the vulnerable ecosystems of the Northwestern Arabian Peninsula

Abstract Mangrove forests are increasingly threatened worldwide and a growing number of regeneration initiatives have surged, aimed at reversing their decline. A critical factor influencing the effectiveness of these efforts is the reproductive success of mangrove plants. In this...