University of Messina

Molecular Basis for Activation to Inhibition Switching in Kv7.2 Channel Modulators

ABSTRACT Kv7 voltage‐gated potassium channels play a critical role in controlling electrical properties of excitable tissues. Neuronally‐expressed Kv7 channels are involved in both common and rare neuropsychiatric disorders, ranging from epilepsy to depression and neurodegenerati...

Continuous Glucose Monitoring and Automated Insulin Delivery in Infants with Type 1 Diabetes: Real-World Evidence to Support Future International Guidelines

To evaluate efficacy and safety of continuous glucose monitoring (CGM) and automated insulin delivery (AID) in infants. A retrospective multicenter study (13 centers) of 76 children diagnosed with antibody-positive type 1 diabetes before age 2. Outcomes at 12 months were compared...

Exploring the potential benefits of allergen immunotherapy beyond respiratory allergy

INTRODUCTION: Allergen immunotherapy (AIT) is the only disease-modifying treatment for IgE-mediated allergic disorders, including allergic rhinitis and asthma, with established long-term clinical efficacy and immunological tolerance induction. AREAS COVERED: This review synthesiz...

Noise protected logical qubit in an open chain of superconducting qubits with ultrastrong interactions

To achieve a fault-tolerant quantum computer, it is crucial to increase the coherence time of quantum bits. In this work, we theoretically investigate a system consisting of a series of superconducting qubits that alternate between XX and YY ultrastrong interactions. By consideri...

Chronological Age and Adaptive Outcomes Following Neuropsychomotor and Aquatic Interventions in Children with Autism: A Secondary Analysis

Background: Autism Spectrum Disorder (ASD) can be conceptualized not as a static condition but as a dynamic disorder of developmental regulation, in which neuroplastic potential is translated into functional gains only through structured, experience-dependent therapeutic input. N...

High‐Responsivity and Fast‐Response Organic Phototransistor Based on Dinaphtho[2,3‐b:2′,3′‐f]Thieno[3,2‐b]Thiophene

ABSTRACT Organic phototransistors (OPTs) are promising as low‐cost detectors compatible with plastic‐substrate electronics for visible light communication (VLC) systems. However, enhancing their sensitivity without sacrificing speed remains challenging. In this work, we report on...

A Modified Delphi consensus on early management of combined cardiovascular risk factors in adult patients with type 2 diabetes in Italy

BACKGROUND: Type 2 diabetes (T2D) is a complex chronic disease often associated with other metabolic conditions that increase the risk of cardiovascular (CV) disease and early mortality. Hence, early, integrated management of T2D may prevent long-term CV complications. METHODS: T...

Liquid Biopsy for Minimal Residual Disease Assessment in Endometrial and Cervical Cancers: Molecular Rationale, Clinical Evidence, and Translational Barriers

Endometrial and cervical cancers can recur from subclinical disease not evident on routine surveillance. This narrative review critically evaluates liquid biopsy for minimal residual disease (MRD) assessment and recurrence monitoring. Post-treatment human papillomavirus (HPV) cir...

Prolonged indolent clinical course in a high-risk chronic phase-CML patient without cytogenetic or molecular response: a case challenging established response paradigms

Chronic-phase chronic myeloid leukemia (CP-CML) is currently treated with tyrosine kinase inhibitors (TKIs), and the early achievement of cytogenetic and molecular milestones is strongly associated with improved clinical outcomes. Here, we describe the case of a 55-year-old woman...

Decoding Synaptic Diversity: Molecular Architectures, Phase Transitions, and Shared Postsynaptic Failure in Alzheimer’s and Parkinson’s Disease

Synaptic failure is the most accurate pathological correlate of cognitive and motor decline in neurodegenerative diseases. However, the molecular logic governing selective synaptic vulnerability in Alzheimer’s (AD) and Parkinson’s (PD) remains a fundamental enigma. This review di...

Inside and outside the body space: a study on environmental knowledge, interoceptive and functional body representations in the prodromal stage of dementia

BACKGROUND: There is increasing interest in identifying sensitive cognitive markers for the early detection of Alzheimer's disease (AD). Spatial navigation has emerged as a promising marker, as impairments in both egocentric and allocentric navigation have been reported in precli...

Sex and gender differences in the effects of immunosuppressive drugs in patients with kidney transplantation

INTRODUCTION Kidney transplantation requires lifelong immunosuppressive therapy, yet substantial interindividual variability in drug exposure and toxicity remains a major clinical challenge. Emerging evidence indicates that sex (biological attributes) and gender (socio- cultural...

Operation Melilli, forensic humanitarian medico legal activities on the largest known Mediterranean disaster: the shipwreck of April 18th, 2015

On April 18th, 2015, a boat carrying about 1,000 migrants sank in the Strait of Sicily, prompting one of the most complex recovery missions ever conducted in the Mediterranean. Operation Melilli was the first time a European Government authorized the recovery of a sunken migrant...