University of Macau

Interpretable machine learning models for analyzing predictors of first-aid knowledge among older adults in Chinese communities: a cross-sectional survey study

This study aimed to investigate the current status of first aid knowledge and its associated factors among community-dwelling older adults using machine learning (ML) models. This cross-sectional study recruited community-dwelling older adults aged 60 years and above. Face-to-fac...

Structural integrity facilitates multi-layer modulation of the brain-metabolome-microbiota network by Lilium lancifolium-derived vesicles in depression

Plant-derived vesicles (PDVs) have emerged as promising natural nanotherapeutics with multi-component cargo profiles and potential biological activity. However, their delivery behavior and mechanisms of action, particularly in complex neuro-immune-metabolic disorders such as depr...

Inferring tumor dependency maps from histopathology through imputed transcriptomics

Gene dependency maps from cancer cell lines define context-specific essential genes, but comparable dependencies in tumors remain largely inaccessible. This gap limits the identification of actionable therapeutic vulnerabilities. Here we present a two-stage deep learning framewor...

Revisiting feeling rules: how emotional labour fosters emotional capital among hospitality and tourism interns in Macao

While emotional labour is well-established in hospitality research, existing scholarship predominantly focuses on established employees, largely overlooking how organisational novices navigate professional socialisation. Specifically, how liminal cohorts like interns manipulate o...

Targeted neuromodulation of perceptual decision-making networks causally dissociates sensory and metacognitive performance

ABSTRACT Perceptual judgements and their subjective evaluation (i.e., metacognition) are considered tightly coupled aspects of decision-making. Yet, emerging evidence suggests that distinct neural mechanisms underlie these processes. In motion perception, studies have identified...

Inflation, innovation, and technology transfer in an open economy with variety expansion

Abstract This study explores the cross‐country effects of inflation on innovation and technology transfer in a North–South variety‐expansion model. We find that higher southern inflation causes a permanent increase in the North–South relative wage ratio, a temporary decrease in t...

The efficacy of stem cell therapy: cells or their microenvironment?

The therapeutic outcomes of stem cell therapy are determined not solely by cellular potency alone, but also by the receptiveness of the host microenvironment. Despite continuous progress in stem cell quality control and functional optimization technologies, inconsistent outcomes...

CalliGAN: multi-scale gradient and self-attention GAN for ancient calligraphy synthesis

Chinese calligraphy synthesis supports digital heritage preservation, but remains challenging due to complex brushstrokes and global structural requirements. We present CalliGAN, a Generative Adversarial Network (GAN) with two variants: CalliGAN-Gen for unconditional character ge...

ProgrammableVersatile Socket: A Tight-Locking andHigh-Gain CRISPR/Cas12a Molecular Circuit for Ultrasensitive Sensingof Diverse Targets

Abstract CRISPR/Cas12a has emerged as an important platform for nucleic acid analysis, yet limited catalytic turnover and intrinsic nucleic acid specificity constrain its sensitivity and analyte scope. Herein, a tight-locking and high-gain Cas12a-driven strand displacement amplif...

Calibrating Mathematics Vocabulary Self-Efficacy: Domain-Specific Accuracy by Mathematics-Difficulty Risk Status

Knowledge of mathematics vocabulary is important for conceptual understanding, yet little is known about how students’ vocabulary self-efficacy corresponds to their performance or how accurately they judge their competence. This study examined relations between mathematics vocabu...

A Stock Market Price Prediction Model Integrating a CNN–Transformer Dual-Channel Dynamic Attention Architecture

Stock market price prediction remains a persistent challenge owing to the non-stationarity, high noise content, and intricate spatiotemporal dependencies that characterize financial time series. Existing approaches typically excel at either local pattern extraction or long-range...

Self-assembled iridium(III) photosensitizers induce cuproptosis without copper supplementation for efficient anticancer therapy

Photodynamic therapy (PDT) is a promising treatment that uses reactive oxygen species (ROS) generated by light-irradiated photosensitizers (PSs) in the presence of molecular oxygen (O₂). However, its efficiency is heavily compromised in aqueous environments and living systems. He...

Tensile Behaviors of Textile Grid–Reinforced One-Part Engineered Geopolymer Composites

Abstract This study developed and characterized textile grid–reinforced one-part engineered geopolymer composites (TR-OPEGCs) via experimental tests (including flow table, compression, direct tension, and textile-reinforced tensile tests) and numerical approaches, focusing on the...

Single‐Cell Transcriptomics and Metabolomics Reveal Glutamate Dehydrogenase as a Central Regulator of Nitrogen Metabolic Remodeling During Alkalinity Adaptation in Crustaceans

ABSTRACT Alkaline environments disrupt ammonia excretion and challenge nitrogen metabolism in aquatic invertebrates, but the underlying cellular mechanisms remain unclear. To elucidate the adaptive mechanisms of crustaceans in highly alkaline environments, the responses of Macrob...

Developmental Relations Between Oppositional Defiant Disorder and Depression in Childhood: A Symptom Level Perspective

Background Oppositional defiant disorder (ODD) has substantial comorbidity with depression. However, their comorbidity at the symptom level, including potential gender differences, is currently underspecified. This study aimed to explore the comorbidity network of ODD and depress...

Terminology for describing the 24-h cycle of physical activity, sedentary behaviour, and sleep: a scoping review

Abstract Background Physical activity, sedentary behaviour, and sleep are three behaviours which occupy the 24-h cycle and interact to influence a multitude of health outcomes. Different terms are currently used to describe these behaviours collectively (e.g., movement behaviours...

A new behavioral evaluation framework for early-stage spatial optimization in high-mobility transit architecture design by applying virtual reality

Efficient wayfinding and spatial comfort are critical performance dimensions for high-mobility transit architecture, yet user-centered evaluation is rarely integrated into early-stage design workflows. This study proposes a virtual reality (VR)-driven behavioral evaluation framew...

Extracting structure–activity relationships from patents with large language models

Abstract Background Persistent clinical failures in drug development arise from multiple factors, including imbalanced molecular properties, underscoring the need for systematic structure–activity relationship analysis to link structural modifications with optimized efficacy, sel...

Mechanical and Structural Performance of 3D-Printed Cement Mortar Incorporating Modified Basic Oxygen Furnace Slag and Waste Printed Circuit Board Powder: Experimental and Numerical Study

This study developed 3D-printable cement mortar (3DPCM) incorporating modified basic oxygen furnace slag (MBOFS) sand and waste printed circuit board powder (WPCBP). Five WPCBP-to-cement ratios, namely 0, 10, 20, 30, and 40 wt.%, were adopted, and the printability of each mixture...