University of Lübeck

Better mental model, fewer watt-hours? Effects of ecodriving tips on knowledge, action regulation, and driving performance in battery electric vehicles

Supporting users in avoiding waste of valuable resources like energy is a key objective in optimising system design. Particularly in battery electric vehicle (BEV) operation, energy efficiency depends on driver behaviour, i.e., on adequate understanding of energy dynamics. Buildi...

Functional characterization of snoRNA-derived RNA (sdRNA) expression in healthy hematopoiesis and acute myeloid leukemia

Abstract SnoRNAs are highly expressed in AML and have implications in leukemogenesis and leukemic maintenance. SnoRNAs can be further processed into snoRNA-derived RNAs (sdRNAs). The role of sdRNAs in AML and healthy hematopoiesis remains largely elusive. We characterized sdRNA a...

Twelve-Month Outcomes After Hearing Rehabilitation With an Active Middle Ear Implant and Latest Generation Vibroplasty Couplers in Adults And Children: A Prospective Multicenter Study

OBJECTIVE: To evaluate the audiological efficacy, patient-reported outcomes, and safety of an active middle ear implant (AMEI) in children and adults with distinct coupling options. STUDY DESIGN: Prospective, longitudinal, multicenter, noninterventional observational study with r...

Tricuspid-Valve Intervention in Heart Failure

BackgroundThe effect of transcatheter tricuspid-valve repair on clinical outcomes, including death and hospitalization for heart failure, in patients with severe tricuspid regurgitation remains uncertain. MethodsWe randomly assigned patients with symptomatic severe tricuspid regu...

Brugada Syndrome in the Pediatric Population: Diagnostic Challenges and Clinical Outcome—Results of the German Multicenter Study COGIA

ABSTRACT Introduction Diagnosis and treatment of children and adolescents with suspected Brugada syndrome (BrS) is challenging. Aim of the study was to evaluate the applicability of current diagnostic criteria for pediatric patients with suspected BrS in the German multicenter st...

Patient-reported outcomes after lateral unicompartmental and total knee arthroplasty: a propensity score-matched cohort study

Abstract Introduction Comparative evidence on patient-reported outcomes (PROs) after lateral unicompartmental knee arthroplasty (UKA) and total knee arthroplasty (TKA) remains limited. We compared PROs between cohorts matched for demographic characteristics and baseline knee func...

From peaks to plummets—linking sleep, effort, and absorption to trajectories of energetic activation during the day

Abstract This study examines daily energy trajectories at work from a temporal self-regulation perspective, addressing the paradoxical finding that effort can be both energizing and depleting. Rather than treating daily energy curves as purely descriptive, we distinguish three se...

Prediction of Treatment Benefit With Internet-Based Cognitive Behavioral Therapy for Depression

Importance Treatment benefit prediction models may help identify which patients will benefit most from internet-based cognitive behavioral therapy (iCBT) for depression; it is unclear whether such models can support useful treatment allocation across programs. Objective To develo...

Patient Pose Assessment Using a CT-Based Framework for Synthetic Data Generation

An adequate diagnostic quality of radiographs is essential for reliable diagnoses and treatment planning. The patient’s pose during radiography is one of the most important factors determining the diagnostic quality. Since patient positioning is difficult and not standardized, an...

Learning curve and target-based accuracy of diode laser versus scalpel incisions in a porcine skin model: a preclinical feasibility study with undergraduate dental students

PURPOSE: Despite the growing clinical application of diode lasers in oral surgery, laser training remains underrepresented in dental curricula. This study evaluated the feasibility of structured preclinical diode-laser training and characterized the early learning curve of underg...

Pediatric intensive care follow-up in Germany is rarely established and highly heterogeneous: a nationwide survey of 20 PICUs

BACKGROUND: Survival after pediatric critical illness has improved substantially, but many survivors and their families experience long-term physical, neurocognitive, psychological and social sequelae, summarized as post-intensive care syndrome in pediatrics and in families. Stru...

Introduction and validation of OSCAR—optimal stent choice algorithm

Abstract Purpose Standardization and international guidelines for stent size selection are lacking. In this study, we introduce and validate an artificial intelligence (AI)- and image processing-supported, modular software algorithm trained on a multicentric vascular segmentation...

Truthful visualizations for mass spectrometry imaging enable high-spatial-resolution interactive m/z mapping and exploration

Mass spectrometry imaging (MSI) produces high-dimensional molecular data, but practical interpretation remains limited by visualizations that incompletely preserve global structure. We present MSI-VISUAL, an open-source framework for interactive MSI analysis that integrates truth...

Gastropexy-Assisted vs. Gastropexy-Free Introducer Percutaneous Endoscopic Gastrostomy: A Prospective Randomized Trial

Introduction: Percutaneous endoscopic gastrostomy (PEG) is a well-established procedure for providing long-term enteral nutrition. Until recently, the only established introducer PEG involved the use of gastropexy sutures. In June 2021, an introducer PEG without gastropexy receiv...

Ultraslow brain dynamics as neurophysiological markers of information sampling during learning

To learn, we must actively sample information from our environment: selecting, prioritizing, and extracting relevant cues. Here, we investigated whether ultraslow event-related potentials (ERPs) could track information sampling as participants learned new words from sentence cont...

Ketamine’s impact on rumination-related brain dynamics: insights from a randomized controlled fMRI trial

Abstract Rumination has been associated with aberrant dynamics of a coactivation pattern (CAP) comprising the default mode (DMN) and frontoparietal (FPN) networks. Ketamine exerts rapid antidepressant effects and may influence these dynamics via glutamatergic mechanisms. In a ran...

Longitudinal progression, metrics, age-dependence, and modifiers of ataxia severity in SCA27B: a multicentre study of 219 patients

Background Spinocerebellar Ataxia 27B (SCA27B) is a novel, frequent and likely treatable late-onset autosomal-dominant ataxia caused by GAA repeat-expansions in FGF14 . For understanding disease evolution and imminent trial planning, metrics of the most widely used clinical outco...

The outpatient economic burden of respiratory syncytial virus infection in adults aged ≥ 60 years in Germany: results from the BUCOSS study

Abstract Background Respiratory syncytial virus (RSV) is a major cause of acute respiratory infection (ARI) in adults aged ≥ 60 years, but data on its outpatient epidemiology and societal costs remain limited. Methods BUCOSS was a prospective observational study conducted over 3...

Learning from Biodegradable Coronary Stents: Future Directions for TPVR Biodegradable Stents

Bioresorbable stents (BRS) have been explored in cardiovascular intervention to provide temporary mechanical support while reducing long-term foreign material. The coronary experience has shown both the potential and the limitations of this strategy. First-generation polymeric st...

Measures for intersectional mental healthcare: results from a participatory interview and focus group study with psychosocial counsellors, people with experience of using mental health services and providers

BACKGROUND: Discriminatory practices and barriers to care are increasingly recognised as a significant challenge for mental healthcare institutions. Yet, little research has considered what measures people with experience of using mental health services and mental healthcare serv...