University of Lübeck

Initial treatment strategies and outcomes across haemodynamic thresholds and risk stratification in incident systemic sclerosis–associated pulmonary arterial hypertension: a EUSTAR analysis

OBJECTIVE: Real-world initial treatment strategies in SSc-PAH remain incompletely described. We aimed to characterise these strategies across haemodynamic thresholds and risk strata and evaluate outcome associations. METHODS: We analysed treatment-naïve SSc-PAH patients in EUSTAR...

Between the Lines: Decoding Signaling Differences in Public and Private Sector Job Advertisements

ABSTRACT To compete in the “war for talent,” public sector employers must demonstrate advantages over private employers. While public service motivation (PSM) predicts sector preference, scholars disagree on whether public employers (can) effectively signal PSM in job advertiseme...

Disease Duration Differentiates Freezing of Gait Response to Subthalamic and Nigral Stimulation for Parkinson's Disease in an Exploratory Multicenter Controlled Trial

BACKGROUND: Freezing of gait (FoG) belongs to most pressing unmet symptoms in the treatment of Parkinson's disease. OBJECTIVES: To explore whether combined subthalamic and nigral (STN + SNr) deep brain stimulation improves FoG compared with optimized STN stimulation alone; to ide...

Molecularly Imprinted Polymers as an Indirect Sensing Approach for Bacillus cereus Detection

Abstract Bacterial endospores are a major challenge in food safety due to their high resistance and potential to cause spoilage and foodborne illness. Current detection methods can be labor-intensive and require specialized instrumentation. A low-cost, label-free thermal sensing...

Outcomes of front-line tagraxofusp in patients with blastic plasmacytoid dendritic cell neoplasm (BPDCN) in a real-world scenario

Abstract Tagraxofusp (TAG), a CD123-directed protein-drug conjugate, is approved in front-line and relapsed/refractory blastic plasmacytoid dendritic cell neoplasm (BPDCN). Multicenter real-world outcomes and the contribution of up-front consolidation post-TAG remain less defined...

RAPNet: Efficient Near-Sensor Radar Data Pre-Processing via DFT-to-GEMM Mapping

Radar is ubiquitous in many domains such as automotive. Modern radar sensors generate large amounts of data that needs to be moved from sensor nodes to Processing Units (PUs). In general, data movement incurs high power consumption and latency. To reduce data movement, processing...

Clindamycin under pressure: resistance in hospitalized patients with odontogenic infections and a penicillin allergy label – a multicenter retrospective study

Odontogenic infections may progress to deep space infection with systemic complications and require prompt surgical drainage and, when indicated, systemic antibiotics. In patients with a documented penicillin allergy label, empiric therapy is often shifted toward clindamycin, alt...

GRETA: a results database for whole-genome sequencing studies

Whole-genome sequencing in large cohorts generates vast numbers of genetic association results, but integrating and querying them alongside public reference data remains a challenge for the diverse stakeholders involved. To address this challenge, we developed the Genetic REsults...

The application value of artificial intelligence in medical imaging: foundations, progress, and challenges

Abstract Artificial intelligence (AI) is rapidly transforming medical imaging, reshaping the field as it does everyday life. As imaging data grow in complexity and clinical workloads continue to rise, AI has become increasingly essential for improving diagnostic efficiency and pr...

Predictors of One-Year Restenosis After Percutaneous Mitral Balloon Valvuloplasty in Rheumatic Mitral Stenosis: Real-World Data From 555 Patients and the Limited Impact of Periinterventional Transesophageal Echocardiography

OBJECTIVE: Mitral balloon valvuloplasty remains an established first-line treatment for appropriately selected patients with rheumatic mitral stenosis. However, predictors of long-term restenosis and the additional value of periinterventional transesophageal echocardiography rema...

Depletion of regulatory T cells breaks self-tolerance and induces epidermolysis bullosa acquisita in resistant C57BL/6J mice

Pemphigoid diseases (PDs) are antibody-mediated autoimmune blistering diseases caused by loss of tolerance to basement membrane proteins such as type VII collagen (COL7), triggering pathogenic T and B cell responses. The contribution of regulatory T cells (T regs ) to disease res...

Efficient Chebyshev reconstruction for the anisotropic equilibrium model in magnetic particle imaging

Abstract Objective: Magnetic Particle Imaging (MPI) is a tomographic imaging modality capable of real-time, high-sensitivity mapping of superparamagnetic iron oxide nanoparticles. Model-based image reconstruction provides an alternative to conventional methods that rely on a meas...

LPV Updates for Sequentially Linearized Moving Horizon Estimation of Nonlinear Systems

ABSTRACT Moving horizon estimation (MHE) provides high‐precision state estimation for nonlinear systems, but it is often limited by the substantial computational demands of solving a nonlinear optimization problem at every sampling step. To address this issue, we develop an effic...

Unsupervised deep learning for inverse problems in computed tomography

Abstract Assume you encounter an inverse problem that shall be solved for a large number of data, but no ground-truth data is available. To emulate this, in this study we assume it is unknown how to solve the imaging problem of Computed Tomography. We introduce an unsupervised de...

Self-compassion is linked to positive affect and buffers declines in self-esteem

Abstract Successes and failures shape affective experiences and self-esteem. Self-compassion has been proposed as a protective factor, allowing individuals to acknowledge both strengths and shortcomings without excessive self-criticism. However, the mechanisms through which self-...

Epitranscriptomic profiling of VSMC phenotypes reveals uridine modifications linked to post-transcriptional regulation

Background The phenotypic plasticity of vascular smooth muscle cells (VSMCs) can modulate atherosclerosis progression. Although several gene regulatory steps towards pro-inflammatory phenotypes have been well-studied, epitranscriptomic changes during this transition and their reg...

Development of a prospective clinical workflow for proton beam therapy of ventricular tachycardia

Abstract Purpose This study presents a prospective preclinical workflow for proton beam therapy of refractory ventricular tachycardia (VT), covering target transfer, treatment planning (TP), and beam gating. Methods Photon-based stereotactic arrhythmia radioablation (STAR) protoc...

cGMP Signaling in Arterioles Revealed by FRET ‐Based Real‐Time Measurement in Mice In Vivo

ABSTRACT cGMP evokes arteriolar vasorelaxation and is generated in smooth muscle by the soluble guanylyl cyclase (sGC) stimulated by endothelial NO. Phosphodiesterases (PDEs) degrade cGMP and may contribute in diameter regulation. We examined arteriolar cGMP levels in real‐time i...

Rheumatologists’ expectations and perceptions of T-cell redirecting therapies: results from a cross-sectional survey

Abstract T-cell redirecting therapies (TCRTs), including Chimeric antigen receptor (CAR)-T cells and T-cell engagers (TCEs), are emerging as transformative treatments for autoimmune diseases. However, clinical application is currently restricted to specialized centers, leaving mo...

Diagnosing autoimmune encephalitis in psychiatry: clinical recommendations and unresolved challenges from the GENERATE network

Psychiatric syndromes can be caused by underlying autoimmune encephalitis (AE). This represents a diagnostic challenge at the interface of psychiatry and neurology. While AE mostly manifests with a combined, complex neuropsychiatric syndrome, some patients with AE may (initially)...