University of Leicester

Expanding CIRdb, a comprehensive catalog of whole-exome sequencing data of Canary Islanders.

) gene, which is associated with body mass index, cardiovascular health, and metabolic and respiratory traits. Taken together, our findings show that CIRdb presents a valuable resource of exome-wide genetic variation in a population at the edge of Southwestern European genetic di...

FHL3 Regulates Vascular Smooth Muscle Cell Phenotypic Switching Through the MRTFB-SRF Signaling Axis

Genome-wide association studies have uncovered many coronary artery disease (CAD) loci, but mechanisms linking risk variants to vascular biology remain unclear. We screen candidate causal CAD genes for regulators of the vascular smooth muscle cell (VSMC) contractile phenotype usi...

Ediacaran coupling of climate and biosphere dynamics

Climate change is demonstrably linked to radiations, extinctions, and turnovers in the biosphere throughout the Phanerozoic (538.8 Ma to present). Here, we suggest this connection existed as early as the late Ediacaran (ca. 579−538.8 Ma), the first interval in Earth’s history to...

Analyzing functional data with a mixture of covariance structures using a curve-based sampling scheme

Abstract Motivated by distinct walking patterns in real-world free-living gait data, this paper proposes an innovative curve-based sampling scheme for the analysis of functional data characterized by a mixture of covariance structures. Traditional approaches often fail to adequat...

GRB 260310A / SN 2026fgk: A Multi-Wavelength Study of a Nearby Underluminous Long GRB and SN with a Complex Afterglow

Abstract We present a comprehensive multi-wavelength study of GRB 260310A / SN 2026fgk, a nearby (z = 0.153), long-duration gamma-ray burst (GRB) with an exceptionally underluminous prompt γ-ray emission and a Comptonized spectrum. The burst occurred at the edge of a blue host ga...

Developing a scalable pipeline for data extraction from clinical letters through resource-efficient prompt engineering

<title>Abstract</title> Free-text clinical records represent an untapped wealth of data for secondary use. Their potential is limited by resource demands necessary for accurate information extraction at scale. We introduce a scalable, resource-efficient, and high-performance pipe...

INTERNATIONAL RESPONSE TO THE RWANDAN GENOCIDE: MISSED OPPORTUNITIES AND THE ORIGINS OF THE MOGADISHU SYNDROME

The 1994 Rwandan genocide remains one of the clearest examples of the international community’s failure to prevent mass atrocities despite credible warnings of impending violence. This paper examines the roles of Belgium, the United Nations Secretariat, the United States, and Fra...

Efficacy of neuromuscular electrical stimulation as a therapy for sarcopenia in people on haemodialysis: study protocol for the STIM-HD randomised controlled trial

Abstract Background Sarcopenia is highly prevalent among adults receiving haemodialysis and is associated with reduced physical function, impaired quality of life, and increased morbidity and mortality. Although structured exercise programmes can improve muscle health, most peopl...

Technical note: reconstructing dose distributions from manually planned electron boosts in breast radiotherapy

Purpose In breast radiotherapy, delivery of manually-calculated electron boosts limits retrospective dose–response analyses as dose distribution is unavailable. This work evaluates the feasibility of reconstructing dose distributions from manually planned electron boosts in breas...

Benefits and challenges of a Patient & Public Involvement (PPI) peer researcher

Involving a patient and public involvement (PPI) peer researcher with lived experience in clinical research is a relatively new concept and to our knowledge, has not been described in adult cardiac surgery. The integration of a PPI peer researcher with a lived experience of a sur...

SMEs’ adaptive capabilities and growth intentions: evidence across different disruption types

Abstract This paper examines how heterogeneous disruptions shape SME growth intentions and how adaptive capabilities influence firms’ responses across different disruption strands. Using five-year longitudinal data on UK small and medium-sized enterprises (SMEs) during the Brexit...

Exposure to workplace bullying and violence/threats of violence and subsequent working life expectancy among older workers: A Swedish prospective cohort study

OBJECTIVES: This study aimed to quantify possible associations between exposure to workplace bullying and violence, or threats thereof, and working life expectancy (WLE) among older workers in Sweden. METHODS: We conducted a prospective cohort study using data on 12 920 individua...

Ascetics, slaves, and necessity in Late Antiquity: renouncing all wealth, but for a single slave

Slave owners in Late Antiquity viewed the possession of at least one slave to be a necessity and a defining mark that distinguished the dignified social classes from the poor. Ascetics who shared this perspective faced a choice when renouncing all worldly possessions in pursuit o...

The Impact Mechanisms and Paths of the National Big Data Comprehensive Pilot Zones on Urban Pollution Reduction and Carbon Mitigation

The National Big Data Comprehensive Pilot Zone (NBDCPZ) constitutes a landmark institutional initiative designed to advance and deploy data elements while strengthening governance capacity for environmental sustainability and low-carbon transition. Drawing on a panel dataset cove...

International healthcare professionals’ competence in caring for LGBTQ+ children and young people: a combined qualitative and quantitative approach

Objective To evaluate healthcare professionals’ attitudes, knowledge and clinical preparedness in caring for lesbian, gay, bisexual, transgender, queer/questioning; the + denoting inclusion of all identities (LGBTQ+) children and young people across international healthcare setti...

Factors Associated With Progression From Level 1 to Level 2 Sensor‐Detected Hypoglycaemia in People With Type 1 and Insulin‐Treated Type 2 Diabetes: A Post Hoc Analysis From the Hypo‐ METRICS Study

ABSTRACT Aims We investigated the proportion of sensor‐detected hypoglycaemic (SDH) events progressing to level 2, and associated variables. Materials and Methods We used data from Hypo‐METRICS, which recruited people with type 1 (pwT1D) and insulin‐treated type 2 diabetes (pwT2D...

Vancomycin optimised dosing regimens for critically ill patients receiving renal replacement therapy

Optimal dosing of vancomycin in critically ill patients receiving renal replacement therapy (RRT) is uncertain due to high pharmacokinetic variability. We aimed to develop individualised vancomycin dosing recommendations that optimise efficacy while minimising toxicity. Prospecti...