University of Ioannina

Enhancement of Endocannabinoid Signaling by Dual MAGL/ABHD6 Inhibition Reduces Neurodegeneration and Neuro-Inflammation Following AMPA-Mediated Excitotoxicity

Excitotoxicity mediated by the α-amino-3-hydroxy-5-methyl-4 isoxazolepropionic acid receptor (AMPAR) is a major contributor to neuronal degeneration and inflammation in various neurological disorders. The endocannabinoid system (ECS), specifically through the endocannabinoid 2-ar...

Regulated Cell Death in Reproductive Biology: Mechanisms and Therapeutic Opportunities

Regulated cell death (RCD) has emerged as a fundamental determinant of cellular homeostasis and tissue remodeling, extending far beyond the classical concept of apoptosis. The identification of emerging RCD pathways, including ferroptosis, pyroptosis, necroptosis, cuproptosis, PA...

Optimizing management strategies for T4b esophageal cancer: the role of TEVAR in multimodal treatment approaches

BACKGROUND: T4b esophageal cancer with aortic invasion remains a major therapeutic challenge because treatment-related tumor regression may precipitate aortoesophageal fistula formation and catastrophic hemorrhage. While chemoradiotherapy is the backbone of disease control, the r...

Cognitive predictors of narrative retelling in early childhood

This study examined the associations between inhibitory control, working memory, inductive reasoning, awareness, and children’s narrative retelling abilities in early childhood. A total of 212 children aged 4–7 years participated in the study. Executive functions were assessed th...

Developmental Language Disorder and Developmental Dyslexia: Rethinking Categorical Boundaries Through a Dimensional Language–Literacy Framework

Developmental Language Disorder (DLD) and developmental dyslexia are among the most prevalent neurodevelopmental disorders affecting children’s language, literacy, academic achievement, and social participation. Although traditionally conceptualised as distinct disorders of oral...

Multi-granularity spatiotemporal flow patterns

Abstract Analyzing flow of objects or data at different granularities of space and time can unveil interesting insights or trends. For example, transportation companies, by aggregating passenger travel data (e.g., counting passengers traveling from one region to another), can ana...

Integrated Molecular, Clinicopathological and Immune Profiling of Non-Small Cell Lung Cancer: The MONREPOS Hellenic Cooperative Oncology Group (HeCOG) Study (HE_2TR/13)

Integrated assessment of tumour genomics and immune biomarkers may improve prognostic stratification in non-small cell lung cancer (NSCLC). We examined the distribution and prognostic relevance of somatic pathogenic/likely pathogenic variants (PVs), somatic copy-number alteration...

Radical splittings of toric ideals

Abstract Let K be a field and let $$I_A\subset K[x_1,\ldots ,x_n]$$ I A ⊂ K [ x 1 , … , x n ] be a toric ideal. We study when $$I_A$$ I A can be expressed in the form $$ I_A=\textrm{rad}(I_{A_1}+\cdots +I_{A_r}),$$ I A = rad ( I A 1 + ⋯ + I A r ) , where $$I_{A_i}\ne I_A$$ I A i...

Critically Exploring Vulnerability in Frail Older Adults Following a Fall

ABSTRACT Vulnerability is widely invoked in healthcare, bioethics, and nursing, yet it remains poorly defined because universal human susceptibility, situational exposure to harm, and clinical frailty are frequently treated as interchangeable. This conceptual ambiguity is particu...

Predicting Adaptive and Maladaptive Narcissistic Traits From Theory of Mind and Empathy in Early Adolescence

This study examined associations between adaptive and maladaptive narcissistic traits, theory of mind (ToM), and empathy in a sample of 10- to 12-year-old adolescents. Participants ( N = 130, M age = 10.84 years, 69 girls) completed self-report measures assessing dimensions of na...

The relationship between personality traits and test anxiety in adolescents: The mediating role of academic hardiness

Recent evidence suggests that test anxiety is widespread among adolescents and associated with adverse academic and psychological outcomes. While the relationship between personality traits and test anxiety is documented, limited research has examined the underlying resilience me...

The role of artificial intelligence in the diagnosis and prognosis of traumatic brain injury based on brain CT scans: a systematic review

Abstract Traumatic brain injury (TBI) is a leading cause of emergency department visits and a major contributor to injury-related mortality and long-term neurological disability. Non-contrast computed tomography (CT) is the gold-standard imaging modality for the rapid diagnosis o...

Colour Doppler ultrasound assessment of retrobulbar hemodynamics and static retinal vessel analysis in Sjögren’s disease: the SICARD cohort

Abstract Objectives To assess, for the first time, macrovascular, medium-calibre vessel, and microvascular damage in Sjögren’s disease (SjD) using carotid greyscale ultrasound (GSUS), retrobulbar colour Doppler ophthalmic artery (OA) ultrasound (RCDUS), and static retinal vessel...

BMAL1 Dysregulation as a Contributing Mechanism Linking Obesity to Oocyte and Endometrial Dysfunction in IVF

Obesity affects nearly one in three women of reproductive age worldwide and consistently reduces success rates in in vitro fertilization, yet the molecular basis for this reduction remains fragmented across separate lines of evidence. Circadian clock genes, particularly BMAL1, or...

The Fibro-Inflammatory Ovary: Stromal Fibrosis, Extracellular Matrix Remodeling, and Mechanotransduction in Female Infertility

Endocrine disorders and inherent flaws in oocyte quality are traditional causes of female infertility. Increasing research indicates that structural and biomechanical alterations in the ovarian microenvironment may significantly contribute to reproductive decline. Progressive ext...

IGF-1Eb Isoform Immunoreactivity May Be Associated with Placental Dysfunction and Vascular Pathology in Fetal Growth Restriction (FGR)

Background: Fetal growth restriction (FGR) is associated with placental dysfunction and adverse perinatal outcomes. Although insulin-like growth factor-1 (IGF-1) signaling is important for placental and fetal development, the mRNA expression, immunopositivity and potential biolog...

Borel regularization and Mellin transform of factorial and left factorial series

Using Borel summation, we assign finite analytic values to the divergent ordinary generating functions of the factorial sequence n! and the left factorial !n. We consider the Mellin transform of the obtained regularized generating functions and derive a bilateral integral represe...

Quality of life and social relationships in people with aphasia: a cross-sectional study

Background Aphasia is a chronic acquired communication disorder that may change the lives of those who live with it. Although its impact on Quality of Life (QOL) is acknowledged, people with aphasia (PWA) remain underrepresented in QOL research. Furthermore, since QOL correlates...

Plasma proteomes of obesity and allometric body shapes in the EPIC cohort

Abstract General obesity (high body mass index, BMI) affects circulating proteins. Obesity-related outcomes, however, differ by body shape but waist and hip circumferences cannot distinguish abdominal from general obesity. We therefore used the allometric body shape index (ABSI),...

Prediagnostic circulating 25-hydroxyvitamin D and prostate cancer-specific survival: a collaborative pooled analysis of 13 prospective studies

Abstract Background Previous research suggests higher risk of prostate cancer diagnosis in men with high vitamin D serology, but there are limited data related to prostate cancer survival. In this study, we examine the associations between prediagnostic circulating levels of 25-h...