University of Iceland

Lifestyle risk factors for cervical glandular and squamous cell neoplasia: insights from a prospective cohort study of over 117,000 women

Abstract Background While cervical cancer screening has successfully reduced squamous cell carcinoma (SCC) rates, adenocarcinoma (AC) incidence is rising, particularly among younger women. Although SCC and AC differ in genomics and treatment responses, evidence regarding their di...

C-Pol: Point-Charge Perturbation Scheme for Mapping Tensor Moment Surfaces

Abstract Molecular polarizability tensors beyond the dipole–dipole level are key inputs to polarizable force fields, polarizable embedding, and machine-learned response models, yet routines to compute them exist in few quantum chemistry codes and are largely confined to atom-cent...

Hurried science and the tracking problem

In times of crisis, science tends to move fast. However, speeding up science often involves deliberate compromises to the scientific norms that are meant to guarantee the reliability of scientific results in normal circumstances. Call this hurried science. Some of the compromises...

Flow‐Critical Graphs

ABSTRACT Lovász et al. proved that every six‐edge‐connected graph has a nowhere‐zero three‐flow. In fact, they proved a more technical statement, which says that there exists a nowhere‐zero three‐flow that extends the flow prescribed on the incident edges of a single vertex with...

Shared transcriptional consequences of epigenetic machinery disruption in murine neuronal progenitors

The Mendelian disorders of the epigenetic machinery (MDEMs) are an emerging group of disorders which commonly involve disruption of intellect and growth. To investigate consequences of epigenetic machinery (EM) disruption during neurodevelopment, we systematically knocked out (KO...

Flourishing under constraint: character education and virtue ethics as the foundation of professionalism in medical education and clinical practice

Contemporary biomedical ethics has been shaped largely by principle-based and outcome-oriented frameworks, yet these approaches insufficiently account for the role of character in clinical judgement and professional formation on which their fruitful use depends. This paper develo...

On Two Types of Mood Shift in Icelandic Conditionals

Abstract Ordinarily, the finite verb of Icelandic "o-marked" conditional ef-protases occurs in the indicative. However, subjunctive finite verbs are obligatory under "conditional inversion," i.e., in V1-protases, and they occasionally show up in present tense ef-protases. In this...

Darkness in the sun?: Imagining a solar energy future in Sierra Leone

Sierra Leone is faced with complex energy challenges, including very low rates of access to electricity. Nevertheless, ambitious goals have been set for the country through the Energy Transition and Green Growth Plan. Opportunities for solar energy deployment feature prominently...

Major adverse cardiac events and mortality associated with ADHD and its treatment in adults with type 2 diabetes: a multi-national cohort study

Abstract Background Attention-deficit/hyperactivity disorder (ADHD) has been linked to elevated risk of type 2 diabetes (T2D). However, the impact of ADHD and ADHD medication use on prognosis and health outcomes in T2D remains unclear. This study investigates the associations of...

More is not always better: Dissociative photoionization limits the EUV absorbing photoacid generator pentafluorophenyl triflate in photolithography

Pentafluorophenyl triflate has been explored as a highly absorbing neutral photoacid generator (PAG) candidate for next-generation chemically amplified resists used in extreme ultraviolet (EUV) lithography. Although increased fluorination enhances EUV absorption, this study demon...

Amphipods associate with epibiotic filamentous bacteria at a shallow-water hydrothermal vent

In the deep ocean, hydrothermal vents sustain remarkable animal-microbial symbioses, in which bacteria colonizing animal external or internal tissues use reduced chemicals from venting fluids to perform chemosynthesis and nourish their host. Hydrothermal vents also occasionally o...

Polaron conductivity in α-Fe2O3 quenched by adsorbed NO2

Polaron-mediated charge transport in α–Fe 2 O 3 plays a central role in its performance as a gas-sensing material, yet the atomistic interaction between surface adsorbates and polarons remains insufficiently understood. Here, density functional theory with Hubbard-U correction (D...

When risk becomes a story: Culture, loss allocation, and lessons from iceland

Abstract When Iceland's three largest banks failed in October 2008, the immediate problem was brutally concrete: a banking system that dwarfed the domestic economy had collapsed, and someone had to absorb the losses. Balance‐sheet structure explains why the banks failed. It says...

Schopenhauer, Compassion, and the Radical Political Subject

Arthur Schopenhauer’s philosophy has been systematically excluded from the canon of radical political thought, dismissed as quietist resignation incompatible with emancipatory projects. This article challenges that exclusion by developing the concept of the pluriversal subject, a...

Application of Machine Learning in Municipal Pavement Condition Predictions

Machine learning (ML) has increasingly become a vital tool for accurate pavement condition prediction, enabling more effective maintenance planning and resource allocation. This study applies the random forest (RF) algorithm to predict the pavement condition index ( PCI ) for 202...

Generational changes in lung function in adults from several world regions: results from the Burden of Obstructive Lung Disease study

This study estimated birth cohort effects on lung function using BOLD (Burden of Obstructive Lung Disease) data from 28 569 adults born between 1902 and 1976 across 41 sites in 34 countries. Forced vital capacity (FVC), forced expiratory volume in 1 s (FEV 1 ) and the FEV 1 /FVC...

Precision Medicine 3.0: Integrating Genomic Stratification with Adaptive Therapeutic Trajectories

Complex diseases require therapeutic decisions that adapt as the disease evolves over time and in response to treatment. Current precision medicine remains largely centered on selecting an individual drug or predefined regimen from molecular characteristics measured at a particul...

rsx: a high-performance streaming toolkit for RAD-seq sex determination

Abstract Background Restriction site-associated DNA sequencing (RAD-seq) is widely used to discover sex-linked markers in non-model organisms, and RADSex provides the reference workflow for building marker-by-individual depth tables and testing sex-biased marker distributions. It...

Phenomic profiles and disease patterns of 1.9 million participants from Our Future Health

Abstract Our Future Health is a prospective study aiming to recruit 5 million UK-resident adults to enable discovery and translation of disease prevention, detection and treatment approaches. So far, more than 2.5 million have enrolled, and baseline phenotypic data are available...

A patient-derived missense mouse model of Kabuki syndrome 1

Kabuki syndrome type 1 (KS1) is a rare cause of intellectual disability resulting from heterozygous pathogenic variants in the gene encoding the histone methyltransferase KMT2D. A previously established loss-of-function mouse model of KS1 exhibits key phenotypic features, and the...