University of Genoa

Construction and characterisation of the DarkSide-20k veto silicon photo-multiplier tiles

Abstract Silicon photo-multipliers (SiPMs) are state-of-the-art sensors capable of detecting a single photoelectron under cryogenic conditions, with potentially lower radioactivity than widely used photomultiplier tubes. The DarkSide-20k experiment, designed to perform direct dar...

Benchmarking foundation models for tumor segmentation across multiple cancer types

Abstract Tumor segmentation is a core task in medical image analysis, with direct implications for diagnosis, treatment planning, and disease monitoring. Whether promptable foundation models are mature enough for heterogeneous oncological scenarios remains an open question. We pr...

Antimicrobial prescribing in adults with acute respiratory infections following rapid six-virus antigen testing: a prospective cohort study in Italian primary care

The overuse of antibiotics for acute respiratory infections (ARIs) is a global challenge. While multiplex rapid antigen detection tests (RADTs) have been proposed to reduce clinical uncertainty, evidence regarding their impact on antimicrobial prescribing in outpatient settings i...

Early Prediction of Carbapenem Resistance in Gram-Negative Organisms at Culture Ordering from Routinely Collected Hospital Data: Temporal and External Validation of ORDER-CARB

Empirical therapy for severe suspected infection is selected before organism identification and antimicrobial susceptibility results are available. ORDER-CARB estimates, at culture ordering, the probability of subsequent recovery of a carbapenem-resistant Gram-negative organism u...

Self-consistent fragmentation in dynamically dense turbulent fibre suspensions

Fragmentation of slender fibres by turbulence controls length distributions in many natural and industrial suspensions, yet most theories assume a prescribed carrier flow, and treat fibres as dilute and dynamically passive. Here, we develop a self-consistent kinetic description f...

Digital twins in neuroscience: A narrative review of technical challenges for child neurology

Digital twins are dynamically updated, patient-specific computational representations that integrate multidimensional data to support prediction and clinical decision-making. This narrative review examines the conceptual foundations and enabling technologies of digital twins in n...

dicast: a machine learning method for accurate structural variant detection from short-read sequencing data

Abstract Structural variants are a common cause of human diseases, but their detection from short-read sequencing remains challenging, despite being the technology underlying most clinical workflows. We present dicast , a machine-learning method that scores SV calls from short-re...

A Cyber-Resilient Zero Trust Architecture for Renewable Energy Communities

Abstract Renewable Energy Communities have emerged as a cornerstone of the rapid transition towards renewable energy sources, where individuals, businesses, and organizations collaborate to generate, share, and consume renewable energy. However, the effective realization of these...

Activities and Role Perceptions of Clinical Research Nurses in Participating Italian Scientific Research Hospitals: A Multicentre Cross-Sectional Survey

Background/Objective: Clinical research nurses (CRNs) support participant care and trial conduct, yet their role is inconsistently recognised and integrated in Italian Scientific Institutes for Research, Hospitalisation and Healthcare (IRCCSs). This study aimed to describe the pe...

From “Share” to Salary: Labour, Remuneration, and Social Change in the Ligurian Seafaring Community of Camogli (1830–1914)

Abstract This article reconstructs how a Ligurian seafaring community moved from communal, profit-sharing forms of maritime enterprise to salaried and increasingly stratified labour during the transition from sail to steam. It traces Camogli’s trajectory from locally crewed vesse...

Research Study Attrition and Participant-Informed Retention Strategies Among Cancer Survivors

Importance Attrition in longitudinal cancer cohorts compromises data completeness, introduces bias, and limits generalizability. Objective To quantify nonresponsiveness over time in a contemporary cohort of cancer survivors, identify individual- and center-level factors associate...

Comprehensive Clinicopathologic, Immunohistochemical, and Genomic Profiling of Sporadic Ampullary Somatostatin-producing D-cell Neuroendocrine Tumors Identifies Recurrent HRAS Hotspot Mutations

Abstract Ampullary somatostatin-producing D-cell neuroendocrine tumors are rare neoplasms that may be associated with type 1 neurofibromatosis. The molecular features of sporadic ampullary somatostatin-producing D-cell neuroendocrine tumors (SAMSOM-NETs) remain poorly characteriz...

From questions to impact in spinal muscular atrophy - identifying community-driven research priorities through a multi-stakeholder European initiative

Abstract Background Advances in medicines have transformed the outlook for people living with spinal muscular atrophy (SMA), yet many needs remain unmet. As the scientific and clinical environment evolves, aligning research priorities with the lived experience of patients is incr...

Measurement Invariance of the Brief State Rumination Inventory Across Administration Methods, National Samples, and Sex

State rumination is a temporary activation of repetitive, negative, self-focused thinking in response to specific situational triggers or mood states. We present the results of two studies that examined the psychometric properties and measurement invariance of the Italian version...

Mapping therapeutic exercise interventions in temporomandibular disorders: A scoping review

OBJECTIVE: Temporomandibular disorders (TMDs) are musculoskeletal conditions causing pain and functional limitations. This scoping review aimed to map therapeutic exercise interventions described in clinical studies on TMDs. METHODS: Following Joanna Briggs Institute methodology,...

ERIES-REVAULTS Pseudo-Dynamic tests on a full-scale masonry cross vault system: dataset

This paper presents the dataset generated within the ERIES-REVAULTs experimental campaign, aimed at investigating the in-plane shear behaviour of masonry cross vaults, representative of historic churches. In post-earthquake surveys, the damage associated with this type of mechani...

Glucose-Derived Carbon Materials via Hydrothermal Carbonization and Pyrolysis for Electrochemical Applications

Abstract Carbon materials are widely used in electrochemical technologies due to their tunable structure and chemical versatility. Hydrothermal carbonization (HTC) of biomass offers a sustainable synthesis route, yet quantitative links between processing conditions and material p...

Forensic challenges in a case of suspected filicide, matricide, and post‐mortem dismemberment

Familicide represents one of the most complex forms of domestic violence in forensic practice. Among intrafamilial homicides, filicide and matricide pose major medico-legal and criminological challenges, particularly when autopsy findings are nonspecific or severely altered by po...

Quality standards for preclinical research in cardio-oncology

Preclinical research in cancer therapy-related cardiovascular toxicity (CTR-CVT) is a major domain of cardio-oncology and has provided biological explanation for the cardiovascular adverse effects of many cancer therapies. However, the choice of the experimental models to investi...

A study on the solidification behaviour of Al–Cr–La alloys in the aluminium-rich region

Abstract This study examines the solidification behaviour of Al–Cr–La alloys, reflecting the increasing use of rare-earth elements to enhance the properties of aluminium alloys. The research aims to determine how the new ternary phase Al 20 Cr 2 La, formed by the addition of La,...