University of Florida Health

scGEN: Leveraging an Adaptive Weighting Strategy for Challenging Cell Clustering in Single‐Cell RNA‐seq

ABSTRACT Recent advancements in single‐cell RNA sequencing (scRNA‐seq) have greatly enhanced our ability to dissect cellular heterogeneity. However, unsupervised clustering often struggles to identify transitional or developmental boundary cells, as existing methods rely on highl...

Addressing non-communicable diseases and injuries through an equity lens: insights from the Cameroon non-communicable disease and injury (NCDI) Poverty Commission

Background: Non-communicable diseases and injuries (NCDIs) constitute a leading cause of premature mortality globally, disproportionately affecting low- and middle-income countries (LMICs). To curb the rising burden of NCDIs in Cameroon, the Ministry of Public Health established...

Periprocedural Anesthesia and Analgesia in Hair Transplantation: An Evidence-Based Review of Contemporary Clinical Practice

BACKGROUND Hair transplantation is a widely performed office-based aesthetic procedure characterized by prolonged procedural duration, cumulative local anesthetic exposure, and reliance on sustained patient cooperation. Despite extensive literature on surgical technique and aesth...

Functional seizures: care experiences of U.S. Veterans and their care partners

Functional seizures (FS) present substantial diagnostic and treatment challenges, particularly for Veterans with multiple medical and psychiatric comorbidities including post traumatic stress disorder, mood disorders and traumatic brain injury. To more effectively care for Vetera...

Grief in Neurosurgery: Reframing Loss and Identity Through Lived Experience.

Grief is an under-recognized yet pervasive experience in neurosurgery, arising not only from the death of patients and loved ones but also from losses related to professional identity, health, and personal relationships. Despite its relevance, grief is often conflated with burnou...

Ceftriaxone versus cefazolin plus gentamicin for antibiotic prophylaxis in Gustilo-Anderson type III open lower extremity fractures

OBJECTIVES: To compare fracture related infection (FRI) rates and outcomes between ceftriaxone (CTX) and cefazolin plus gentamicin (C+G) for antibiotic prophylaxis in Gustilo-Anderson (GA) type III open lower extremity fractures. METHODS: Design: Retrospective cohort study. SETTI...

Global burden of moyamoya syndrome in pediatric sickle cell disease and implications for the neurosurgical workforce: a systematic review

Abstract Objective The aims of the study were twofold: 1) quantify the global burden of pSCD|MMS, and 2) estimate the number of children who warrant specialist evaluation for possible surgical revascularization. Methods A systematic review was conducted following PRISMA guideline...

Evidence-informed trial recruitment planning: an integrative review of infectious disease trials in Africa

Persistent recruitment and retention challenges undermine trial feasibility, particularly in infectious disease trials. While regulatory frameworks like ICH-GCP and WHO-GCP emphasize ethical trial conduct, they provide limited operational guidance. This integrative review aimed t...

A yeast model for the functional analysis of SRP54 mutations associated with severe congenital neutropenia

Mutations in the human SRP54 gene are linked to the pathophysiology of severe congenital neutropenia (SCN). SRP54 is a key protein comprising one of the six protein subunits of the signal recognition particle responsible for cotranslational targeting of proteins to the ER. Crysta...

Beta-Lactam Dose Optimization Using Therapeutic Drug Monitoring in Pediatric Patients

OBJECTIVE: Beta-lactam therapeutic drug monitoring (BL-TDM) is underused in pediatric patients where drug exposure is highly variable. This study evaluated the pharmacokinetic/pharmacodynamic (PK/PD) target attainment of BLs in pediatrics. PATIENTS AND METHODS: A retrospective ob...

Evaluating sexual violence bystander intervention in alcohol-serving venues: a quasi-experimental protocol for assessing individual, interpersonal, and venue-level intervention effects

Alcohol is a leading risk factor for sexual violence (SV) victimization, perpetration, and reduced bystander intervention. Social environments where heavy drinking occurs (e.g., bars), and the staff who work within them, represent unique targets for SV prevention. Bar-based bysta...

Leveraging dog models to uncover human cancer insights

Background: Comparative genomics can reveal insights into human disease that cannot be identified from human data alone. Dogs are particularly useful for comparative genomics studies as they share human diet and environment, and, from a genomics perspective, dogs are closely rela...

Structural requirements for intelligent clinical digital twins in feedback-driven care

Clinical digital twins are increasingly promoted for decision support, yet most are designed and validated for prediction under observed care rather than decision-support validity. We identify four structural requirements for intelligent clinical digital twins used in bidirection...

Distinguishing Benign from Malignant Small Enhancing Breast Lesions Using Radiomics

Background/Objectives: Small enhancing lesions (often termed foci if lesion ≤ 5 mm) observed on breast magnetic resonance imaging (MRI) pose a persistent challenge. Their clinical relevance and the most effective management strategy remain unclear, often leading to unnecessary bi...

Pilot Voided Volume Validation Study: Sound-Based Smartphone Applications Can Accurately Measure Voided Volume

Background/Objectives: The objective of this study was to test the accuracy of two sound-based voided volume measurement applications compared to voided volume based on the measurement of pre- and post-void weight using a high-resolution scale. Methods: Seven male and four female...

The Effects of Partnership‐Based Cause‐Related Marketing Program on Consumers' Perceived Authenticity, Meaningfulness, and Supporting Behaviors: Moderating Roles of Perceived Pain and Calling

ABSTRACT The effectiveness of cause‐related marketing (CRM) depends on how CRM initiatives are designed and communicated to consumers. To advance theoretical understanding of effective CRM practice, drawing on the attribution theory and martyrdom effect, the current study examine...

Structural Heart Interventions in Women with Congenital Heart Disease

Abstract Purpose of Review To provide a review of current transcatheter interventions in women with congenital heart disease, with a focus on sex-specific considerations in diagnosis, management, and follow-up. Recent Findings As the field of pediatric cardiology advances and pat...

A data-driven single substitution to overcome bias from conventional single substitution for LOD missingness in covariates in least squares regression

The Limit of Detection (LOD) is the threshold below which a measurement is considered too low to be reliably quantified. Even though advanced statistical methods exist for dealing with the values below the LOD, simple approaches are still frequently used in real-world settings. C...

Liver Fat Changes in Patients With Type 2 Diabetes by Presence of Genetic Hepatic Steatosis: A Post Hoc Analysis of SURPASS ‐3 MRI

ABSTRACT The patatin‐like phospholipase 3 (PNPLA3) I148M genetic variant is highly associated with steatotic liver disease. In the SURPASS‐3 MRI substudy, tirzepatide significantly reduced liver fat content (LFC) versus insulin degludec in insulin‐naïve patients with type 2 diabe...

Response to “Prepregnancy GLP ‐ 1 Receptor Agonist Use: Unaccounted Pretreatment BMI May Distort Obstetric Outcome Signals in Real‐World Studies”

Data sharing not applicable to this article as no datasets were generated or analysed during the current study.