University of Florence

Dual Delivery from a Multilayer Buccal Film: Rational Design of a Combination Product for Localized Treatment of Oral Fibrosis

Oral submucous fibrosis (OSF) is a chronic, progressive, and potentially malignant disorder characterized by severe oral cavity remodeling. The condition is driven by a painful burning sensation and a pathognomonic restriction of mouth opening (trismus), severely diminishing pati...

Hydrogen staging effects on flame stability and emissions in a fuel-flexible combustor

This study investigates the impact of fuel split between Jet-A1 and H 2 in a novel low-swirl combustor designed for low NO x emissions and flashback resistance. The combustor combines airblast atomization for Jet-A1 with H 2 injection in a jet-in-crossflow configuration. Full and...

Early Introduction and Prolonged Full‐Dose Anakinra Reduce Recurrence Risk After Discontinuation in Recurrent Pericarditis: An International Multicenter Cohort

Background Anakinra is effective in recurrent pericarditis, yet optimal treatment duration and strategies for safe drug discontinuation remain uncertain. Identifying predictors of sustained remission after discontinuation is important for clinical management. Methods We retrospec...

Rethinking Solid-Phase Microextraction (SPME) for Bioanalysis: Workflow Optimisation in Automated Vacuum-Assisted Cooling SPME for Fatty Acid Monitoring in Faecal Waters

Short-chain fatty acids (SCFAs) are key biomarkers of gut microbiota and intestinal health, yet their analysis is challenging due to high volatility, hydrophilicity, and the complexity of the faecal matrix. This study introduces a novel, green, and fully automated workflow for mo...

Eating Behavior, Body Appreciation, and Sleep Quality in Italian Blind Baseball Athletes: A Cross-Sectional Exploratory Survey

Background/Objectives: Visual impairment is associated with poor sleep quality, psychological distress, and unhealthy lifestyle behaviors. Adapted sports, such as blind baseball (BXC), may help promote healthy lifestyles and overall well-being. However, evidence regarding eating...

ERGA-BGE reference genome of the bladderpod Alyssoides utriculata (L.) Medik. (Brassicaceae), a yellow-flowering shrub native to Switzerland

We present the chromosome-level genome assembly for bladderrpod, Alyssoides utriculata (Brassicales: Brassicaceae), the only currently accepted species in the genus Alyssoides. The phased assembly comprises two haplotypes with total lengths of 1.01 Gb and 0.98 Gb, respectively. F...

An Integrated Human-in-the-Loop Patent Search Workflow: An Exploratory Case Study Combining Keyword, Similarity, Semantic, and Citation-Based Retrieval

Patent retrieval is important for innovation management, R&D planning, and intellectual property strategy, yet conventional searches are hindered by terminology variability, synonymy, broad patent scopes, and classification limitations. This study presents an integrated, iterativ...

Initial treatment strategies and outcomes across haemodynamic thresholds and risk stratification in incident systemic sclerosis–associated pulmonary arterial hypertension: a EUSTAR analysis

OBJECTIVE: Real-world initial treatment strategies in SSc-PAH remain incompletely described. We aimed to characterise these strategies across haemodynamic thresholds and risk strata and evaluate outcome associations. METHODS: We analysed treatment-naïve SSc-PAH patients in EUSTAR...

Emerging therapeutic strategies and clinical trials in severe asthma management: current evidence and future directions

Introduction Biologic therapies have transformed the management of severe asthma, particularly in type 2-high disease, but important unmet needs remain. Incomplete responses, uncertainty in treatment positioning, and the lack of effective options for non-type 2 or mixed inflammat...

Training the Next Generation of Future Surgical Residents: A Scoping Review and Proposal for an Undergraduate Curriculum From the Italian Polispecialistic Society of Young Surgeons

AIM: The transition from medical school to surgical residency is marked by a persistent gap between theoretical instruction and clinical readiness. In Italy, variability in training programs across centers creates persistent gaps in residents’ medical education. Scientific societ...

Nonlinear ferroelectric wires under periodic live loads: waves with period matching the forcing

Abstract We consider the dynamics of nonlinear elastic ferroelectric wires subjected to periodic external forcing. For general free energies, we determine conditions under which wave-type solutions, including the polarization field, have a period matching the one of periodic exte...

Travel distance to tertiary healthcare reflects disease severity and medication access in Italian systemic sclerosis patients: a geographical study on adult-onset rare diseases from SPRING-SIR registry

Systemic sclerosis (SSc) is a rare, multiorgan disease in adults that requires specialized care. Commuting to tertiary medical centers poses a considerable burden and incurs significant costs, potentially affecting management choices. This study aims to describe the healthcare co...

Vitamin D status and adiposity in children with low-energy fractures: a prospective case–control study

Fractures in children are influenced by both skeletal biology and mechanical factors. While alterations in vitamin D and other metabolic markers have been proposed as contributors to fracture risk, their role in predicting fractures in otherwise healthy pediatric populations rema...

Validation of the International Working Group 2023 response criteria for higher risk myelodysplastic syndromes/neoplasms using the International Consortium for Myelodysplastic Syndromes VALIDATE database and a randomized phase III trial

Response assessment criteria in patients with higher-risk myelodysplastic syndromes/neoplasms (HR-MDS) have been updated in the 2023 International Working Group (IWG) criteria. However, validation of these criteria has been limited to date. We analyzed overall survival (OS) by be...

Autologous haematopoietic stem cell transplantation affects paramagnetic rim lesions in multiple sclerosis

Background: Available literature shows a marginal or no effect of disease-modifying therapies on paramagnetic rim lesions (PRLs), a promising magnetic resonance imaging marker of chronic inflammation in multiple sclerosis. Objective: To investigate longitudinal changes in PRL cou...

Reconciling intrinsic and ecosystem water-use efficiency reveals physiological mechanisms underlying carbon-water coupling across biological scales

Understanding how carbon-water coupling scales from leaves to ecosystems remains a major challenge because water-use efficiency (WUE) metrics integrate physiological, hydrological, and ecological processes. We integrated tree-ring width, triple stable isotopes (δ13C, δ18O and δ2H...

Optimizing subtraction-based approaches in time-domain diffuse optics by a time-window analysis

Diffuse optics measurements performed in the time domain provide the highest information level, but are plagued by a low spatial resolution and significant sensitivity to superficial regions (e.g., extracerebral changes). Here we compare the two main analysis methods (namely, sta...

Bite mechanics within the wolf lineage: feeding capabilities of Canis borjgali and Canis mosbachensis inferred by digital bite simulation

Abstract Genus Canis species plays a key role as predator in terrestrial ecosystems. However, the evolutionary history of these carnivorans is still not fully understood. To explore this topic, we studied the bite of two fossil close relatives of the modern grey wolf, Canis borjg...

Cutaneous Lymphoma International Prognostic Index and Risk Stratification in Advanced Mycosis Fungoides and Sézary Syndrome

Importance Risk stratification in advanced mycosis fungoides and Sézary syndrome (MF/SS) remains suboptimal given that current TNMB (tumor, node, metastasis, blood) staging has limited prognostic value for clinically relevant outcomes. Objective To determine whether the Cutaneous...

Morphological and morphometric variability in Quaternary rhinoceroses as revealed by a small-sized adult Stephanorhinus etruscus skeleton from Poggio Rosso in Upper Valdarno (Early Pleistocene, Italy)

A nearly complete skeleton of Stephanorhinus etruscus from the Upper Valdarno Basin (Italy) provides a rare opportunity to investigate the morphological and morphometric variability of Early Pleistocene rhinoceroses. The specimen, IGF8212V, is here described and compared with S....