University of Ferrara

Antidepressants and breast cancer risk: a meta-analysis of exposure windows and cumulative use in nearly two million women

Abstract Background The use of antidepressants is steadily increasing worldwide. This trend has a significant impact on public health and socioeconomic conditions. Although studies have looked for a possible link between antidepressants and breast cancer risk, findings remain unp...

Preservation and Reuse of KLEx Lenticules: From Biobanking to Therapeutic and Refractive Innovations

Stromal keratophakia was first introduced by Jose Ignacio Barraquer in the 1960s as a refractive procedure involving the implantation of a stromal lenticule into a lamellar keratectomy bed of a recipient cornea. By increasing central corneal thickness, the added lenticule induced...

Disease progression in hidradenitis suppurativa: A multidimensional framework

Abstract Hidradenitis suppurativa (HS) is increasingly recognized as a progressive inflammatory disease in which recurrent follicular inflammation, tunnel formation and systemic inflammation drive cumulative, largely irreversible tissue damage, quality‐of‐life impairment and card...

Cancer Burden and Inflammaging Among People Living with HIV: An Inflammatory Biomarker Analysis from an Italian Cohort

Background/Objectives: Despite effective antiretroviral therapy, cancer remains a relevant comorbidity in people living with HIV (PLWH), with an increasing burden of non-AIDS-defining cancers (NADCs). We assessed cancer prevalence and systemic inflammation using a composite score...

First-Line Immune Checkpoint Inhibitors in Older Patients with Advanced Urothelial Carcinoma: A Systematic Review and Meta-Analysis

Urothelial carcinoma predominantly affects older patients, who often exhibit frailty, comorbidities, renal impairment, and reduced physiological reserve. We evaluated overall survival (OS) and progression-free survival (PFS) with first-line immune-based strategies in patients age...

Management of Acute Periodontal Conditions—The EFP S2k Level Clinical Practice Guideline

BACKGROUND: The European Federation of Periodontology (EFP) has developed Clinical Practice Guidelines (CPGs) for the treatment of periodontitis and for the management of peri-implant diseases. In accordance with the 2018 Classification, acute periodontal conditions are character...

Tozorakimab to Prevent COPD Exacerbations

BACKGROUND: Many patients with chronic obstructive pulmonary disease (COPD) have exacerbations despite receiving standard-of-care inhaled maintenance therapy. Dysregulated interleukin-33 signaling is implicated in the pathogenesis of COPD. Tozorakimab is a monoclonal antibody tha...

DISE and Rhinomanometry Correlates of Response to Head‐of‐Bed Elevation in Obstructive Sleep Apnea

OBJECTIVES: To identify endoscopic and rhinomanometric correlation of response to 30° head-of-bed elevation (HOBE) in patients with obstructive sleep apnea (OSA), and to explore whether upper airway (UA) collapse patterns and nasal resistance are associated with positional improv...

Reproducible human reward imaging phenotypes exhibit differential sensitivity to dopamine D2 receptor antagonism

Abstract Human reward processing varies along cue-centric and outcome-centric axes, but a reproducible mechanistic account of individual variation in incentive salience attribution has been lacking. Using fMRI across five cohorts (N-total=1,251; N1=890; N2=245; N3=34; N4=48; N5=3...

Taxonomic reassessment and palaeobiogeographical patterns of some Miogypsinidae species, larger benthic foraminifera

Abstract. The Miogypsinidae comprise orbitoidal larger benthic foraminifera with generally eccentric position of the nepionic stage and a fan of equatorial chamberlets; the members of this family are widely used in biostratigraphy of upper Oligocene–middle Miocene deposits. Here,...

Tissue and Cerebral Biofluid Remodelling of tRNA-Derived Small RNA Signatures in Experimental and Human Epilepsy

Small noncoding RNAs are increasingly recognized as important regulators of gene expression in brain diseases including epilepsy. tRNA-derived small RNAs (tsRNAs) including tRNA fragments (tRFs) and tRNA halves (tiRNAs) are emerging as stable and regulated RNA species which respo...

Managing the Difficult Airway in Adults with Life-Threatening Cervical Infections: A Scoping Review

Background: Airway management in patients with cervical infections remains a major challenge because progressive swelling and distortion of the upper airway may rapidly lead to life-threatening airway obstruction. Despite advances in imaging and advanced intubation techniques, th...

Topical Ruxolitinib for Folliculitis Decalvans

The authors declare no conflicts of interest. The data that support the findings of this study are available from the corresponding author upon reasonable request.

European S2k guidelines for hidradenitis suppurativa/acne inversa Part 1. Epidemiology, diagnosis and clinical assessment

BACKGROUND: This first part of the S2k guidelines is an update of the 2015 S1 European guidelines based on the structured assessment of clinically relevant topics by the panel of experts. It is complemented by Part 2, which deals with treatments. OBJECTIVES: These guidelines aim...

Effectiveness of Multidomain Cardiac Rehabilitation After Myocardial Infarction by Patient Frailty: Prespecified Subgroup Analysis of the PIpELINe Trial

BACKGROUND: Frailty is common among older patients surviving myocardial infarction, is associated with adverse outcomes, and is often perceived as a barrier to cardiac rehabilitation (CR). The aim of this study is to determine whether frailty influences prognosis after myocardial...

The quest for the optimal level of sense of agency in the case of human-operated, AI-enabled robotics

Sense of agency is the subjective feeling of being in control over one’s own actions and their sensory outcomes. Here, we propose that a key feature of sense of agency is its link to intrinsic motivation, which is a key driver for engagement with the environment without external...

Bimodal multiphoton catalysis via structural regeneration

Abstract Most of the current photocatalytic methodologies for the generation of reactive radical intermediates have limited redox windows and can operate within a single redox manifold. Here, to overcome these constraints, we report a purely organic photocatalyst that operates vi...

Reduced Serum PON1 Lactonase Activity Is Associated with Mild Cognitive Impairment and Mixed Dementia

High-density lipoprotein (HDL)-associated paraoxonase-1 (PON1) contributes substantially to the antioxidant and anti-inflammatory functions of HDL. Impairment of these protective properties has been associated with Alzheimer’s disease (AD) and other forms of dementia, particularl...

Simplified SPAL technique to provide adequate peri‐implant phenotype: A pilot study

BACKGROUND: Correction of peri-implant bone dehiscence (PIBD) and optimization of the peri-implant soft-tissue phenotype are critical for long-term peri-implant tissues stability. A simplified, one-stage, transmucosal variant of the subperiosteal peri-implant augmented layer (sSP...

Operation Melilli, forensic humanitarian medico legal activities on the largest known Mediterranean disaster: the shipwreck of April 18th, 2015

On April 18th, 2015, a boat carrying about 1,000 migrants sank in the Strait of Sicily, prompting one of the most complex recovery missions ever conducted in the Mediterranean. Operation Melilli was the first time a European Government authorized the recovery of a sunken migrant...