University of Dundee

Calculation of Field-line Slippage Rates in Coronal Simulations

Abstract We present the universal Slippage calculator ( USlip ), an extension of the universal Fieldline Tracer ( UFiT ), which computes magnetic field line slippage rates from an input magnetic field defined on a structured grid. The slippage rate provides a local, physically gr...

Management of Acute Periodontal Conditions—The EFP S2k Level Clinical Practice Guideline

BACKGROUND: The European Federation of Periodontology (EFP) has developed Clinical Practice Guidelines (CPGs) for the treatment of periodontitis and for the management of peri-implant diseases. In accordance with the 2018 Classification, acute periodontal conditions are character...

Dual plasmepsin IX and X inhibitors are refractory to development of resistance

Abstract Artemisinin-based combination therapies (ACTs) remain the cornerstone of malaria treatment, but emerging resistance threatens their efficacy. The potential for the development of drug resistance against plasmepsin X (PMX)-selective inhibitors and dual plasmepsin IX/X (PM...

Reconstitution of multistep recruitment of ULK1 to membranes in autophagy

Abstract The Human ULK1 autophagy-initiating complex consists of ULK1, FIP200, and the HORMA domain heterodimer ATG13:ATG101. PI3P is essential to recruit ULK1C to membranes for ULK1, but ULK1C subunits do not contain PI3P-binding domains. Here we show that the ATG13:ATG101 dimer...

“Thank you for the feedback, but no!” Listening to the experiences of first-year students encountering the “power” of teacher feedback

The study takes place in a Higher Education Institution in the Netherlands amongst first-year social science students and investigates their experiences of receiving teacher feedback. It specifically examines student feedback sense-making and responses, as well as how the surroun...

Tumor-derived antioxidants suppress immunity by depriving T cells of reactive oxygen species

Reactive oxygen species (ROS) promote genomic instability and fuel oncogenic signaling in cancer, but antioxidant therapies have so far failed to improve, or worsen, cancer outcomes. Emerging data suggest that T cells depend on ROS for signal transduction. In this study, we show...

Luminescence dating of offshore tsunami deposits from the Shetland Islands, United Kingdom

Abstract. With onshore geological evidence of three tsunami events, the Shetland Islands (UK) yield the most-detailed Holocene tsunami record in the North Sea region. Lately, tsunami deposits were also identified in shallow waters offshore the Shetland Islands. These offshore tsu...

Recruiting a geographically, ethnically and socioeconomically diverse population of postpartum women into a behavioural weight management intervention trial: an evaluation of strategies used in the Supporting MumS (SMS) randomised controlled trial

Abstract Background Engaging women in behavioural weight management interventions in the postpartum period has proved challenging. Previous trials of such interventions have frequently experienced issues with participant recruitment and retention and recruited samples have been s...

A reduced order model framework suitable for geotechnical problems

Abstract Data-driven methods are of increasing popularity for solving problems in geotechnics, offering as they do, the possibility of high-fidelity results without the effort of a detailed deterministic numerical analysis (e.g. using finite elements). A wide range of approaches...

Sequential restriction of SNARE-mediated fusion by the COPII inner coat and SNARE chaperones

Abstract SNARE-mediated fusion requires assembly of four SNARE domains (R, Qa, Qb, and Qc) distributed across two membranes, with an SM (Sec1/Munc-18 family) chaperone catalyzing this assembly. We investigated topological requirements for the four SNAREs that mediate ER-Golgi fus...

Conceptualising Governmentality and Sustainable Urban Planning in Malta: A Foucauldian Analysis of the National Planning Framework

Malta, as a small Mediterranean island state, faces distinctive challenges in achieving sustainable urban development, including limited land resources, environmental vulnerabilities, and demographic pressures. Whilst the Maltese planning practice addresses these challenges throu...

Implementation of an AI-simulated consultation platform for undergraduate clinical communication training: a service evaluation

Abstract Background AI-simulated consultation platforms are increasingly used to support clinical communication training in medical education, with systematic reviews reporting comparable or improved skills outcomes across digital simulation modalities [1, 2]. However, much of th...

Quality of Outcome Reporting for Older Subgroups in FDA Registration Gastroesophageal Cancer Trials (2010–2024): A Systematic Review

Background: Gastroesophageal adenocarcinoma is predominantly a disease of older adults. However, older adults are underrepresented in randomised controlled trials (RCTs), and outcomes specific to this subgroup are underreported. Clinicians therefore extrapolate data from younger,...

Chinese Painting Semantic Resource for Resolution-Aware Digitisation and Structured Heritage Access

Chinese painting digitisation poses a distinctive heritage-informatics challenge: culturally salient visual structures such as brushwork, intentional blank space, and text–image coexistence are difficult to document, access, and research with general-purpose collection and comput...

FAF1 and FAF2 enhance unfolding by p97-UFD1-NPL4 complex enabling rational design of p97 activators

Abstract VCP/p97 is an AAA+ ATPase that, together with its cofactors UFD1-NPL4 (p97-UN), unfolds ubiquitylated substrates to maintain cellular homeostasis. The human p97-UN complex associates with additional cofactors, but how these cofactors modulate p97-UN activity is not fully...

Digital mourning: Revisiting COVID-era #funeral discourse on Twitter

The COVID-19 pandemic substantially disrupted funeral practices across the world, as public health restrictions limited gatherings and altered how funerals and mourning practices could take place. This study serves as a retrospective account of funeral-related discourse on Twitte...

Effect of chronic high‐altitude hypoxia on retinal vascular phenotype, choroidal and retinal vasoreactivity in Peruvian highlanders

Abstract High‐altitude chronic hypoxia can induce excessive erythrocytosis (EE, defined as a haemoglobin concentration of ≥21 g/dL in men), leading to hyperviscosity and promoting endothelial dysfunction. We aimed to assess whether EE affects the retinal vascular phenotype and th...

Deep learning-based prediction of self-energies from ab initio dynamical mean-field theory for real materials with minimal data sets

Abstract Density-functional theory (DFT) has been the workhorse of first-principles calculations for decades, and DFT-derived energies and forces are now widely used to train machine learning models of inter-atomic potentials. However, DFT’s single-particle treatment of exchange-...

Discovery of Sphaeriaurantinsas Rapid-Acting Antiplasmodialswith Dual Activity in Blood and Liver Stages

Abstract The rapid emergence of resistance in the malaria-causing protozoan Plasmodium falciparum has heightened the demand for treatments with novel modes of action. Having evolved to produce a myriad of structurally diverse natural products (NPs) as defenses against soil-dwelli...

Adiponectin promotes AMPA receptor trafficking and enhances excitatory synaptic transmission at hippocampal synapses via AMP‐activated protein kinase signalling

Background and Purpose Peripherally derived adiponectin crosses the blood–brain barrier and targets severa0l brain regions. Adiponectin receptors are highly expressed in the hippocampus, and play a pro‐cognitive role as adiponectin markedly influences the functioning of hippocamp...