University of Dundee

Relocation, laser dusting and suction (RELOADUS): An international collaborative observational study for laser management to prevent strictures of symptomatic impacted upper ureteric stones

Background Ureteric stricture formation following ureteroscopy and laser management of stones is known. Objective To evaluate the feasibility, safety, stone clearance outcomes and rate of upper ureteric stricture formation after implementation of the Relocation, laser dusting and...

AI chatbot integration in fashion e-retail: consumer behaviour shifts and pathways to organizational change

Purpose AI chatbots are increasingly embedded in customer-facing retail operations, yet research has examined them mainly as tools of individual adoption. This study positions consumer attitudinal and behavioural responses to chatbots in fashion e-retail as micro-level foundation...

Emerging therapeutic strategies and clinical trials in severe asthma management: current evidence and future directions

Introduction Biologic therapies have transformed the management of severe asthma, particularly in type 2-high disease, but important unmet needs remain. Incomplete responses, uncertainty in treatment positioning, and the lack of effective options for non-type 2 or mixed inflammat...

Augmenting colonoscopy with artificial intelligence and robotic assistance: a human-factors scoping review toward a task-based shared autonomy paradigm

Colonoscopy is central to colorectal cancer prevention but remains a high-demand psychomotor and cognitive procedure, characterized by operator dependency, variable performance, and substantial physical and mental workload. Increasing evidence links procedural quality and safety...

Briefing: From urban foresight to project bundles—the case of Huntsville, Alabama

Urban foresight and its project packages may follow linear temporality paths towards intended urban futures. Changes in conditions in one project package might affect the others. This briefing argues that project bundling can offer a more dynamic way to implement these visions. S...

Drought responses of a Norway spruce forest on drained peat soil: combining sap-flow sensors, eddy-covariance, meteorological, soil and UAV data

Abstract. The summer of 2021 brought a severe drought to southern Finland. We explored how a drained boreal peatland forest responds to drought by combining a wide range of in situ monitoring and Unmanned Aerial Vehicle (UAV) remote sensing. A dataset combining eddy-covariance (E...

Profiling peripheral immune cells in Parkinson's disease: A scoping review

Parkinson's disease (PD) is increasingly recognized as a multi-system disorder with immune dysregulation extending beyond the central nervous system. Although numerous studies have examined peripheral immune alterations in people with PD, findings remain heterogeneous and difficu...

Enhancement of hippocampal synaptic AMPA receptor function by the antidepressant tianeptine and by opioid peptides

Management of major depressive disorder (MDD) with conventional therapeutics that enhance monoaminergic neurotransmission requires prolonged treatment prior to clinical benefit and a substantial proportion of patients show little or no improvement. Identifying alternative molecul...

A mathematical theory of redox biology

Abstract Redox biology is commonly described through functional labels, such as oxidant, reductant, antioxidant, signalling mediator or damage mediator. However, these labels do not define invariant molecular properties. A molecule may realize different functions depending on rea...

Gaze and Facial Expression‐Based Multimodal Network for Depression Assessment in Young Adults

ABSTRACT Depression remains a critical mental health challenge worldwide, particularly among young adults. Traditional assessment methods often raise privacy concerns and can heighten psychological resistance. To overcome these barriers, we introduce the Gaze and Facial Expressio...

PCSK9 inhibitors usage in South China: A Multi-Center Real-World Study

Proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9i) are effective for lipid management in high-risk patients with atherosclerotic cardiovascular disease. Their inclusion in China’s National Reimbursement Drug List and the Hong Kong Hospital Authority Drug Formulary...

Safety and feasibility of drainless day-case parotidectomy: an 8-year retrospective cohort study from a tertiary centre

PURPOSE: Our retrospective study in 2025 found that the use of haemostatic agents in drainless outpatient parotidectomy (DLOP) is associated with an increased risk of seroma/sialoma formation and possible increase in infection risk. The aim of this study was to compare additional...

A standardized clinical algorithm for patient selection in cellular therapy across nineteen solid and hematological malignancies: An algorithm development study

ABSTRACT Background: Cellular therapies—chimeric antigen receptor T-cell (CAR-T), tumor-infiltrating lymphocyte (TIL), T-cell receptor (TCR)-engineered, gamma-delta (γδ) T-cell, and high-dose interleukin-2—have transformed the management of refractory malignancies. Over 6,000 int...

Functional pathway phenotyping reveals increased LRRK2 activity beyond recognised genetic causes of Parkinson’s disease

Abstract Pathogenic LRRK2 variants cause Parkinson’s disease (PD) through increased kinase activity, with VPS35 p.D620N and other emerging genetic factors also increasing LRRK2 signalling. Findings in idiopathic PD also suggest broader LRRK2 pathway involvement. As LRRK2-targeted...

Genetic and pharmacologic inhibition of Keap1 dampens the pro-fibrotic program in human hepatic stellate cells

Abstract The increasing prevalence of chronic liver diseases (CLDs) is a global health concern. CLDs can cause fibrosis, and there is an urgent need for antifibrotic agents. The primary driver of fibrogenesis, transforming growth factor beta 1 (TGF-β1), activates hepatic stellate...

Fitness criteria for PROTACs as chemical probes: principles and applications

Proteolysis-targeting chimeras (PROTACs) have emerged as a powerful class of chemical probes that degrade rather than inhibit target proteins, thus expanding the tools for studying protein function in cells. PROTACs trigger catalytic and sub-stoichiometric degradation of the targ...

Individualized breast cancer survival prediction in clinical practice: a SEER-derived interactive web tool integrating molecular and anatomical factors

BACKGROUND: Accurate patient-level risk prediction supports treatment decisions in breast cancer. Using the U.S. Surveillance, Epidemiology, and End Results (SEER) registry, we developed and internally validated an interactive web-based survival calculator integrating molecular a...

Experiences and challenges of neurosurgical residents during the COVID 19 pandemic in Sabah Malaysia

This study explores the multifaceted impact of the COVID-19 pandemic on neurosurgical resident training and their emotional well-being. The rapid global spread of COVID-19 necessitated unprecedented changes in healthcare systems, significantly altering medical education and clini...

Management of Acute Periodontal Conditions—The EFP S2k Level Clinical Practice Guideline

BACKGROUND: The European Federation of Periodontology (EFP) has developed Clinical Practice Guidelines (CPGs) for the treatment of periodontitis and for the management of peri-implant diseases. In accordance with the 2018 Classification, acute periodontal conditions are character...

A pragmatic Approach to Technology Selection for RSEs: Lessons from iDiabetes

Digital technologies are rapidly reshaping clinical trials, enabling fully remote and data-intensive studies through web/mobile applications, wearable devices, and integrated health systems. As a result, clinical trial platforms have become complex software systems, placing Resea...