University of Dundee

Chinese Painting Semantic Resource for Resolution-Aware Digitisation and Structured Heritage Access

Chinese painting digitisation poses a distinctive heritage-informatics challenge: culturally salient visual structures such as brushwork, intentional blank space, and text–image coexistence are difficult to document, access, and research with general-purpose collection and comput...

Digital mourning: Revisiting COVID-era #funeral discourse on Twitter

The COVID-19 pandemic substantially disrupted funeral practices across the world, as public health restrictions limited gatherings and altered how funerals and mourning practices could take place. This study serves as a retrospective account of funeral-related discourse on Twitte...

FAF1 and FAF2 enhance unfolding by p97-UFD1-NPL4 complex enabling rational design of p97 activators

Abstract VCP/p97 is an AAA+ ATPase that, together with its cofactors UFD1-NPL4 (p97-UN), unfolds ubiquitylated substrates to maintain cellular homeostasis. The human p97-UN complex associates with additional cofactors, but how these cofactors modulate p97-UN activity is not fully...

Effect of chronic high‐altitude hypoxia on retinal vascular phenotype, choroidal and retinal vasoreactivity in Peruvian highlanders

Abstract High‐altitude chronic hypoxia can induce excessive erythrocytosis (EE, defined as a haemoglobin concentration of ≥21 g/dL in men), leading to hyperviscosity and promoting endothelial dysfunction. We aimed to assess whether EE affects the retinal vascular phenotype and th...

Deep learning-based prediction of self-energies from ab initio dynamical mean-field theory for real materials with minimal data sets

Abstract Density-functional theory (DFT) has been the workhorse of first-principles calculations for decades, and DFT-derived energies and forces are now widely used to train machine learning models of inter-atomic potentials. However, DFT’s single-particle treatment of exchange-...

Discovery of Sphaeriaurantinsas Rapid-Acting Antiplasmodialswith Dual Activity in Blood and Liver Stages

Abstract The rapid emergence of resistance in the malaria-causing protozoan Plasmodium falciparum has heightened the demand for treatments with novel modes of action. Having evolved to produce a myriad of structurally diverse natural products (NPs) as defenses against soil-dwelli...

Adiponectin promotes AMPA receptor trafficking and enhances excitatory synaptic transmission at hippocampal synapses via AMP‐activated protein kinase signalling

Background and Purpose Peripherally derived adiponectin crosses the blood–brain barrier and targets severa0l brain regions. Adiponectin receptors are highly expressed in the hippocampus, and play a pro‐cognitive role as adiponectin markedly influences the functioning of hippocamp...

Factors Associated With Progression From Level 1 to Level 2 Sensor‐Detected Hypoglycaemia in People With Type 1 and Insulin‐Treated Type 2 Diabetes: A Post Hoc Analysis From the Hypo‐ METRICS Study

ABSTRACT Aims We investigated the proportion of sensor‐detected hypoglycaemic (SDH) events progressing to level 2, and associated variables. Materials and Methods We used data from Hypo‐METRICS, which recruited people with type 1 (pwT1D) and insulin‐treated type 2 diabetes (pwT2D...

Healthy Personality Patterns Predict Higher Well-Being but Limited Stability and Change

Abstract Healthy personality, characterised by higher extraversion, agreeableness, conscientiousness, and openness alongside lower neuroticism, has been associated with adaptive functioning and well-being. However, it remains unclear whether these associations reflect similarity...

Designing transformative sustainability education: a mixed methods study exploring the values and perspectives of medical students

Abstract Introduction Education for Sustainable Healthcare (ESH) is a novel area of medical education and high-quality evidence to guide effective learning approaches is yet to be established. This study investigates the design of ESH in undergraduate medicine through the lenses...

Hydrological modelling in snow- and glacier-fed catchments of the Upper Indus Basin by conceptual and machine learning approaches

Study region Upper Indus Basin (UIB), Himalaya and Hindu Kush. Focus of study This study evaluates the performance of a conceptually based glacio-hydrological model (GSM-HBV) and four data-driven models (DDMs), namely LSTM, RF, XGB and SVM, to simulate annualised, seasonal and fl...