University of Debrecen

MALDI-TOF Mass Spectrometric Characterization of Polyacrylamide Multiblock Copolymers Reveals Structure–Property Relationships

Abstract A novel series of multiblock copolymers composed of alternating poly(N-acryloylmorpholine) (PNAM) and poly(N-isopropylacrylamide) (PNIPAM) segments were synthesized using reversible addition–fragmentation chain-transfer (RAFT) polymerization to explore the relationship b...

Prospective, randomized comparison of electromyographic neuromuscular responses from the adductor pollicis and abductor digiti minimi muscles during rocuronium-induced neuromuscular block

Background: Many clinicians monitor the abductor digiti minimi (ADM) muscle during surgery using electromyography (EMG) for ease and consistency of electrode placement, while practice guidelines recommend monitoring of responses at the adductor pollicis (AP) muscle. We compared t...

Stable Oil-in-Water Nanoemulsions Stabilized by Polygonatum sewerzowii Extract: A Plant-Derived Alternative to Synthetic Surfactants

Growing demand for clean-label ingredients has intensified the search for sustainable plant-derived emulsifiers capable of replacing synthetic surfactants in nanoformulations. In this study, the emulsifying potential of crude Polygonatum sewerzowii extract (PSE), obtained by opti...

Rate-dependent electrochemical degradation of NCA /graphite-Si lithium-ion batteries under mechanical vibration

Li-ion batteries (LIBs), which serve as the primary energy source for electric vehicles (EVs), are routinely exposed to mechanical vibrations during real-world operation. While such vibrations are often overlooked, they may profoundly affect battery aging behavior over time. In t...

Data-Mining-Based Detector Calibrations for High-Energy Physics

The generation of Dead Hot Maps (DHMs) is an important part of PHENIX data analysis, as it helps reduce detector-related biases. During this step, detector units with abnormal behavior are identified, such as dead, hot, or extremely hot channels. Removing these channels from the...

Mitigating the bullwhip effect: the role of ESG performance in Chinese enterprises

Abstract Supply chain resilience is vital to the long-term operation of enterprises. With the concept of sustainable development becoming deeply ingrained globally, enterprises are actively implementing environmental, social, and governance (ESG) practices. Based on panel data of...

Motivational drive influences motor and cerebellar alterations in the triple transgenic Alzheimer’s disease model

Abstract Alzheimer’s disease (AD) is accompanied by early motor alterations, yet the contribution of motivational state and testing history to these changes remains poorly understood. We examined locomotor, fine-motor, and molecular profiles in 6–8-month-old male 3xTg-AD mice acr...

Digital maturity and financial balance: a deep analysis of performance management in Hungarian E-commerce enterprises from 2019 to 2023

This research examines performance measurement practices and financial effectiveness in Hungarian e-commerce from 2019 to 2023, addressing how inconsistent decision-support systems challenge sustainable profitability. Conducted across a structured multi-phase research timeline (2...

Prognostic value of the identified genus of anaerobic bacteria in bloodstream infection beyond host-related risk factors: a five-year retrospective cohort study

BACKGROUND: Anaerobic bacteraemia is an uncommon but clinically significant bloodstream infection associated with substantial mortality. The respective roles of pathogen-specific and host-related factors in determining outcomes are not fully elucidated. AIM: To identify predictor...

Establishment of a novel human nervous system tissue bank: University of Debrecen tissue bank—introduction and retrospective data analysis

Abstract Human brain tissues obtained from autopsies, as well as muscle and nerve samples derived from biopsies, constitute indispensable resources for translational research investigating the pathomechanisms of neuropsychiatric disorders. In this study, we introduce the Nervous...

Associations Between Short Video Exposure, Empathy and Attitudes Toward End‐Of‐Life Care Among Nursing Students: A Cross‐Sectional Study

ABSTRACT Aim This cross‐sectional study examined the associations between short video exposure, nursing students' empathy, and attitudes toward end‐of‐life (EOL) care, and tested whether perceived impact is statistically consistent with an indirect pathway in these relationships....

Spheroidal Resampling Analysis of High-Redshift Gamma-Ray Burst Spatial Densities

Gamma-ray bursts (GRBs) are bright transient sources that can be observed at high redshift. They can therefore be used as tracers of the distant large-scale structure, although the GRB redshift sample is sparse and affected by strong selection effects. We analyze the three-dimens...

Synergistic effects of lean-green practices on sustainable supply chain performance with a multi-factor moderation analysis

Abstract This study contributes by examining the impact of lean and green practices on sustainable supply chain performance, focusing specifically on songket artisan small and medium-sized enterprises (SMEs) in Bali, Indonesia. The study examines the moderating effects of top man...

Cancer in systemic sclerosis: clinical associations and prognostic impact from the EUSTAR registry

BACKGROUND: Cancer represents a major cause of mortality in systemic sclerosis (SSc). Established risk factors are limited to specific subsets, particularly early diffuse anti-RNA polymerase III (POLR3)-positive disease, needing further exploration. METHODS: We performed a nested...

Variation in meningioma recurrence risk estimates across observational cohorts: the influence of calendar time, WHO classifications, geographical settings, and healthcare systems

Abstract Purpose Recurrence risk estimates underpin meningioma research, including molecular classification and clinical trial benchmarking, yet are often based on retrospective or historical data. The aim of this study was to assess the variation of recurrence risk estimates acr...

Physiological Hypoxia and Pharmacological HIF Stabilization Induce Distinct but Overlapping Responses in Retinal Pigment Epithelial Cells

Background/Objectives: Hypoxia is a major contributor to the development of retinal diseases by promoting metabolic adaptation and pathological angiogenesis through hypoxia-inducible factor (HIF) signaling. HIF-prolyl hydroxylase inhibitors (HIF-PHIs), which stabilize HIF under n...

Longitudinal metagenomic insights into soil, bark, and berry microbiomes under abandoned, bio-organic, and conventional cultivation in Tokaj vineyard

Abstract This two-year longitudinal metagenomic study in Tokaj, Hungary, profiled soil, bark, and grape berry microbiomes across three cultivation regimes (abandoned, bio-organic, conventional) and two vintages (2020–2021), using 16S rRNA and shotgun metagenomics coupled with cli...

Application of magnetically separable silica aerogel-supported palladium catalyst in the hydrogenation of aromatic nitro compounds

Abstract Palladium nanocatalyst has been prepared via sonication-induced reductive deposition for the hydrogenation of nitro groups, tested in the two industrially most significant nitro compound hydrogenation processes: nitrobenzene hydrogenation to aniline and 2,4-dinitrotoluen...

A Simulation-Based Optimization Framework of Stochastic Manufacturing Systems Using External Optimizer

In this paper, we investigate a simulation-based optimization framework that implements discrete-event simulation with evolutionary search methods to optimize stochastic manufacturing systems efficiently. The proposed methodology couples a Tecnomatix Plant Simulation model with a...

European S2k guidelines for hidradenitis suppurativa/acne inversa Part 1. Epidemiology, diagnosis and clinical assessment

BACKGROUND: This first part of the S2k guidelines is an update of the 2015 S1 European guidelines based on the structured assessment of clinically relevant topics by the panel of experts. It is complemented by Part 2, which deals with treatments. OBJECTIVES: These guidelines aim...